Kai Wang

MicroRNA-23C Impacts Hepatocellular Carcinoma Metastasis by Targeting OTUB1

Ya-Nan Ji, Kai Wang, Zhong-Quan Yi, Siyu Gu et autres

BACKGROUND: MicroRNA-23C (miR-23C) and Ovarian Tumor domain-containing Ubiquitin Aldehyde-Binding protein 1 (OTUB1) have been crucially implicated in numerous malignancies, such as Hepatocellular Carcinoma (HCC), a common malignant tumor. Herein, the function of the miR-23C-OTUB1-PI3K/AKT signaling pathway in HCC cell aggressiveness and Epithelial-Mesenchymal …

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Lactate Promotes Liver Regeneration by Increasing Fatty Acid Oxidation Through GCN5-Mediated H3K9 Lactylation

Xun Qiu, Hanzhi Xu, Lijun Meng, Yunguo Lei et autres

BACKGROUND & AIMS: Lactylation has been implicated in the repair and regeneration of multiple organs, including the skin and the heart. The liver serves as a vital organ for lactate metabolism, whereas the roles of lactate and lactylation during liver regeneration remain …

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Circ_GLS/miR-410-3p/GSK3beta/beta-catenin axis modulates malignant phenotypes of non-small cell lung cancer cells via regulation of cell cycle, apoptosis, ferroptosis, and EMT

Kai Wang, Zimei Wu, Tao Lu, Jiajie Wang et autres

Lung cancer, with non-small cell lung cancer (NSCLC) representing 85 % of cases, has high global incidence and mortality. Early detection is challenging, often leading to late-stage diagnosis and missed surgical opportunities, highlighting the need for novel biomarkers and therapeutic targets. CircRNA …

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CD302 regulates the malignant phenotypes of lung adenocarcinoma as a tumor suppressor gene

Kai Wang, Yao Wang, Tao Lu, Manjun Gao et autres

Background: CD302 encodes a transmembrane glycoprotein involved in immune regulation via cell-extracellular matrix interactions. Its role in lung adenocarcinoma (LUAD) remains unexplored. This study investigates CD302's expression, clinical relevance, and functional mechanisms in LUAD. Methods: CD302 overexpression models in A549 and PC-9 …

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Preoperative plasma ceramide profiling coupled with machine learning accurately predicts recurrence of hepatocellular carcinoma after resection

Lei Yang, Xuming Mo, Baoxiong Zhuang, Qingping Li et autres

BACKGROUND: Accurate stratification of recurrence risk after curative resection remains a critical challenge in the management of hepatocellular carcinoma (HCC). Dysregulated ceramide (CER) metabolism has been implicated in HCC progression and relapse. This paper evaluates whether preoperative plasma CER profiling coupled with …

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The value of fibroblast growth factor 21 (FGF21) promoter methylation in the repair and regeneration during the course of chronic hepatitis B

Xue Li, Ying Zhang, Jihui Li, Tong Gang Zhao et autres

Background: Hepatitis B virus (HBV) infection continues to pose a significant threat to global public health. The capacity for liver repair and regeneration plays a critical role in maintaining liver homeostasis during HBV infection. This study investigates the impact of FGF21 promoter …

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Deep learning-based non-invasive prediction of PD-L1 status and immunotherapy survival stratification in esophageal cancer using [18F]FDG PET/CT

Fei Xie, Mobei Zhang, Chunhong Zheng, Zhenwei Zhao et autres

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Prospective multicenter validation of preoperative plasma ceramides as novel predictive biomarkers for clinically relevant post-hepatectomy liver failure

Hanbiao Liang, Haiqing Liu, Jieyuan Li, Biao Wang et autres

BACKGROUND: Circulating ceramides (CERs) are associated with liver diseases and dysfunction. The utility of plasma CERs in predicting post-hepatectomy liver failure (PHLF) remains unclear. This study aimed to evaluate the clinical utility of preoperative plasma CERs for predicting clinically relevant PHLF (CR-PHLF). …

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Prognostic risk model of six m7 g-related lncRNAs in lung adenocarcinoma

Kaijun Long, Kai Wang, Manjun Gao, Yao Wang et autres

BACKGROUND: Lung cancer is the most widespread and fatal oncological disease, with lung adenocarcinoma (LUAD) being the predominant subtype, characterized by a poor long-term survival rate. Although the N7-methylguanosone (m7G) genes have been reported to be correlated with the prognosis of lung …

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Landmark-Free Preoperative-to-Intraoperative Registration in Laparoscopic Liver Resection

Jun Zhou, Bingchen Gao, Kai Wang, Jialun Pei et autres

Liver registration by overlaying preoperative 3D models onto intraoperative 2D frames can assist surgeons in perceiving the spatial anatomy of the liver clearly for a higher surgical success rate. Existing registration methods rely heavily on anatomical landmark-based workflows, which encounter two major …

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Learning-based early detection of post-hepatectomy liver failure using temporal perioperative data: a nationwide multicenter retrospective study in China

Kai Wang, Qian Yang, Kang Li, Shanhua Tang et autres

Background Post-hepatectomy liver failure (PHLF), defined as acute liver failure following hepatectomy, remains a major complication for postoperative mortality lacking early detection approaches. This study aimed to leverage cutting-edge artificial intelligence (AI) techniques for extensive temporal feature analysis using perioperative data, to …

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Targeting the ceramidase ACER3 attenuates cholestasis in mice by mitigating bile acid overload via unsaturated ceramide-mediated LXRβ signaling transduction

Leyi Liao, Ziying Liu, Lei Liu, Can Huang et autres

Bile acid overload critically drives the pathogenesis of cholestatic liver injury (CLI). While ceramide metabolism has garnered increasing interest in liver research, the role of ceramides in CLI remains unclear. This study investigates the function of alkaline ceramidase 3 (ACER3)-catalyzed hydrolysis of …

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