Zhong Wang

Family Structure and Bullying Perpetration Among Adolescents: Direct and Indirect Pathways

Zhong Wang, Shiming Hao, Zhang Yan

This study examines relationships among family structure, social bonds, bullying peer associations, and bullying perpetration among Chinese adolescents, integrating social control and social learning perspectives. Using survey data from 2,085 junior high school students in China and generalized structural equation modeling, we …

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Exploring the mechanism of Madetuliayate Formula on denervated muscle weakness and atrophy based network pharmacology and validation analysis

Shadaitihan Musha, Abudourexiti Tuersongtuoheti, Miriguli Bake, Nabijan Mohammadtursun et autres

Background The Madetuliayate Formula (MDTF) is a traditional Chinese medicine that shows promise in treating nerve injury (NI) and its complications, including muscle weakness (MW) and muscle atrophy (MA). However, the specific bioactive compounds and pharmacological mechanisms underlying its therapeutic effects remain …

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Cynomorium songaricum polysaccharide attenuates high-fat diet-induced testicular dysfunction by modulating the gut microbiota

P. Huan, Wei Wang, Yujuan Qi, Jiahao Sun et autres

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Development and validation of a Hypoxia and Lactate Metabolism Prognostic Score (HLMPS) for breast cancer using machine learning

Shichong Liao, Zhong Wang, Juanjuan Li, Lijun Wang et autres

Background: Previous studies often overlooked the roles of hypoxia and lactate metabolism in the breast cancer (BRCA) microenvironment. This study developed and validated a novel prognostic model for BRCA based on hypoxia-related genes (HRGs) and lactate metabolism-related genes (LMRGs) using machine learning …

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Bioinformatics revealed biomarkers for diagnosis in kidney stones

Ziqi He, Chao Song, Zhong Wang, Caitao Dong et autres

Background: One of the most prevalent urinary illnesses is kidney stone formation, often known as nephrolithiasis. The precise processes of kidney stone remain poorly known after substantial investigation. In order to successfully prevent and cure stone formation and recurrence, additional research into …

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Development of coenzyme Q10-related molecular subtypes and a prognostic signature for predicting breast cancer prognosis and response to immunotherapy

Shichong Liao, Yue‐Yue Guo, Juanjuan Li, Zhong Wang et autres

Background: Breast cancer (BRCA) remains by far the most life-threatening malignancy in women. Resistance to BRCA treatment may be counteracted by the induction of ferroptosis in combination with immunotherapy. The study aims develop iron death-related prognostic models to predict prognosis and immunotherapy …

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Comprehensive analysis reveals cholesterol metabolism-related signature for predicting prognosis and guiding individualized treatment of glioma

Dengfeng Lu, Fei Wang, Yayi Yang, Aojie Duan et autres

Objective: Gliomas are the most common intracranial tumors with the highest degree of malignancy. Disturbed cholesterol metabolism is one of the key features of many malignant tumors, including gliomas. This study aimed to investigate the significance of cholesterol metabolism-related genes in prognostic …

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Hepatic squamous cell carcinoma initially presenting as cholecystitis misdiagnosed as cholangiocarcinoma: A case report

Ge Shi, Xinhan Ye, Fangjia Yang, Zhong Wang et autres

Primary squamous cell carcinoma of the liver (PSCCL) is a rare intrahepatic primary tumor. Due to a lack of distinctive clinical presentations and radiological features, early diagnosis is challenging. The present study, describes a patient who initially presented with symptoms indicative of …

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Early recurrence and extensive retroperitoneal metastasis after surgery for high‑grade mucinous tubular and spindle cell carcinoma: A case report and literature review

Xiaofeng Ma, Jin Xu, Xinhan Ye, Fangjia Yang et autres

Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare subtype of renal cancer. The present report details the treatment experience of a case of MTSCC, where the patient underwent a right-side laparoscopic nephrectomy in October 2020 at Zhuji People's Hospital (Zhuji, …

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STELLAR-303: randomized phase III study of zanzalintinib + atezolizumab in previously treated metastatic colorectal cancer

Anwaar Saeed, Josep Tabernero, Aparna R. Parikh, Marc Van den Eynde et autres

Most patients with metastatic colorectal cancer (mCRC) have limited treatment options following standard-of-care therapy. VEGFR-tyrosine kinase inhibitors (TKIs) have demonstrated clinical activity in mCRC in combination with immune checkpoint inhibitors (ICIs), particularly in patients without liver metastases. The TKI zanzalintinib (XL092) targets …

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Brusatol hinders the progression of bladder cancer by Chac1/Nrf2/SLC7A11 pathway

Xi Yu, Ziqi He, Zhong Wang, Shuai Ke et autres

Bladder cancer is a common tumor that impacts the urinary system and marked by a significant fatality rate and an unfavorable prognosis. Promising antineoplastic properties are exhibited by brusatol, which is obtained from the dried ripe fruit of Brucea javanica. The present …

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Inhibiting RIPK1-driven neuroinflammation and neuronal apoptosis mitigates brain injury following experimental subarachnoid hemorrhage

Yan Wu, Yao Xu, Jingshan Sun, Kun Dai et autres

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