Yin Chen

AI-enabled viral genomics: from virus discovery to host prediction and emerging variant forecasting

Jincan Ke, Heng Rong, Yin Chen, Xiaojuan Zhu et autres

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Pediatric appendicitis caused by a single hair

Yin Chen, Ping Zhou, Chao Ma

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SMAD4–BPIFA1 Axis Governs Airway Antiviral Defense in Myhre Syndrome

Y. Peter Di, Bodong Wen, Fengyuan Li, Felicia Tang et autres

Myhre syndrome is a rare autosomal-dominant disorder caused by gain-of-function (GOF) variants in SMAD4. Although it is primarily recognized as a fibrotic disease, we and others have identified respiratory infection-associated morbidity as a major clinical burden. Regardless, the epithelial-intrinsic mechanisms underlying increased …

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Changes of Tissue Reactions on Various HA Filler Under Immune Stress Status: An In Vivo Study

Yin Chen, Y Zhang, Weijin Hong, Sheng‐Kang Luo

BACKGROUND: Post-COVID-19, there has been an increase in reports of anaphylaxis to hyaluronic acid (HA) filler injections. OBJECTIVE: This study aimed to investigate the differences in tissue reactions induced by HA fillers produced via various cross-linking technologies under conditions of immune stress. …

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EulerESG: Automating ESG Disclosure Analysis with LLMs

Yi Ding, Xushuo Tang, Zhengyi Yang, Wenqian Zhang et autres

Environmental, Social, and Governance (ESG) reports have become central to how companies communicate climate risk, social impact, and governance practices, yet they are still published primarily as long, heterogeneous PDF documents. This makes it difficult to systematically answer seemingly simple questions. Existing …

Antigenic Imprinting and Immune Response Dynamics: Neutralization Against Emerging SARS‐CoV‐2 Omicron Variants Following Breakthrough Infections

Jianhua Li, Xingxing Wang, Jiaxuan Li, Yin Chen et autres

The recently mutated Omicron variant of SARS-CoV-2 exhibits extremely high infectivity and strong evolution and immune escape capabilities. Given the unique epidemic prevention policies of China, we collected 16 sets of sera from convalescent individuals (n = 308) with breakthrough infections who …

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A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2

Yankai Chu, Shishuang Chen, Mingyang Yang, Yin Chen et autres

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Droplet digital RT-PCR method for SARS-CoV-2 variants detection in clinical and wastewater samples

Feng Wang, Yi Sun, Liming Gong, Lingxuan Su et autres

Objective: To establish a sensitive, specific, and precise quantitative detection method for SARS-CoV-2 variants using droplet digital RT-PCR (RT-ddPCR). Methods: Dual primer-probe sets targeting the SARS-CoV-2 nucleocapsid (N) and spike (S) genes were designed. The annealing temperature for RT-ddPCR was optimized using …

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An outbreak of human respiratory syncytial virus infection in the rural community of Zhejiang Province in 2023

Jinren Pan, An Zhu, Wanwan Sun, Yu Zhao et autres

In May 2023, three patients from a village were admitted to the pediatric wards of the Second People's Hospital of Jinyun County due to human respiratory syncytial virus (human RSV) infections. One doctor notified this event to the local Center for Disease …

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Pinoresinol Diglucoside Attenuates Nuclear Receptor Coactivator 4‐Mediated Ferritinophagy Associated with Cisplatin‐Induced Hearing Loss

Yin Chen, Cheng Cheng, Ao Li, Dengbin Ma et autres

Cisplatin can cause irreversible hearing loss. However, effective approaches to its prevention are not established. In this study, the effect of the traditional Chinese medicine monomer pinoresinol diglucoside (PDG) is evaluated on cisplatin-induced ototoxicity and its underlying mechanism of action. PDG significantly …

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Comparative efficacy and acceptability of non-invasive neuromodulation technologies and botulinum toxin injections for post-stroke spasticity and motor function: a network meta-analysis of randomised controlled trials

Jiapeng Huang, Chuncha Bao, Yin Chen, Wenyi Zhu et autres

Background: Non-invasive neuromodulation is a promising approach for improving spasticity and motor function after stroke. However, it is still unclear which type of non-invasive neuromodulation is effective and evidence of important differences between them and botulinum toxin (BoNT) injection is limited. We …

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Cutaneous adverse events associated with BRAF and MEK inhibitors: a systematic review and meta-analysis

Junhui Qian, Jinlong Wan, Yao Qin, Yin Chen et autres

Aim Cutaneous adverse events (CAEs) after treatment with BRAF and MEK inhibitors in patients with melanoma remain incompletely characterized. To determine the association of BRAF and MEK inhibitor treatment with CAEs in patients with melanoma compared with BRAF inhibitor alone. Method PubMed, …

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