Li Zhang

Parthenolide: Unlocking the Multitarget Molecular Regulatory Network of Neurological Diseases

Yifan Jiang, Xiaoyu Zhang, Yiyang Sun, Tiantian Hou et autres

INTRODUCTION: Neurological diseases with a complex etiology and diagnostic complexities are one of the major causes of disability and death globally. In previous preclinical studies, it has been shown that parthenolide (PTL) can provide significant neuroprotective potential. The review synthesizes the mechanistic …

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5 at.%-vanadium hybriding enables silicon anode with high initial coulombic efficiency and low internal stress

Shouxiang Mark Ma, Li Zhang, Zhongqiu Tong, Jie Yu et autres

Silicon anodes are promising for high-energy-density lithium-ion batteries. Nevertheless, unsatisfied initial Coulombic efficiency (ICE) and structure collapse are two barriers still hindering their application. Here, we report a 5 at%-vanadium hybriding strategy to stabilize Si film anode to deliver a high initial …

Global research dynamics in metabolic biomarkers and cancer: a bibliometric study from 2015 to 2025

Li Zhang, Yanxiao Sun, Yuxia Ma

OBJECTIVE: Metabolic biomarkers are important for the early detection and prognostic assessment of cancer. Nevertheless, a bibliometric analysis examining their research landscape within this domain has not been performed. This study seeks to investigate the current research landscape of metabolic biomarkers related …

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Effects of non-invasive brain stimulation on balance control in patients with multiple sclerosis: a systematic review and meta-analysis

Li Zhang, Yanxiao Sun, Zhihao Diao, Yifan Jiang et autres

Objective: This study aims to evaluate the effects of non-invasive brain stimulation (NIBS) on balance control in patients with multiple sclerosis (MS) through a systematic review and meta-analysis. The goal is to identify the most effective treatment strategies and provide valuable evidence …

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Research on intelligent traffic flow forecasting and dynamic dispatching model based on network computing

Li Zhang

The study first developed a multi-source data collection and processing system, utilizing microwave radar sensors, weather data, and social media event information, by utilizing distributed storage and computing technologies such as Hadoop and Spark, this approach facilitates the efficient collection, storage, and …

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Design of real-time fault detection and automatic recovery algorithm in intelligent transportation systems

Li Zhang

With the rapid development of intelligent transportation systems, the complexity and real-time requirements of traffic management are increasing. Fault detection and automatic recovery, as an important part of intelligent transportation system, plays a crucial role in ensuring the efficient operation and safety …

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Acupuncture combined with mouse nerve growth factor in the treatment of peripheral facial palsies: systematic review and meta-analysis

Yufei Hu, Y. N. Liu, Zhihao Diao, Yifan Jiang et autres

Background Peripheral facial palsies (PFP) had been listed as a dominant disease of acupuncture. Numerous researchers had utilized acupuncture in conjunction with mouse nerve growth factor (mNGF) for PFP. However, there is little relevant systematic and standardized evidence-based medicine, and the efficacy …

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Peripheral immune imbalance in pediatric fulminant myocarditis revealed by single-cell sequencing and plasma proteomics

Keyu Liu, Li Zhang, Xiuyun Duan, Hailin Jia et autres

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A rare concurrence of monoclonal gammopathies in an older adult with tubulointerstitial nephritis and uveitis syndrome

Jianhui Zhang, Jie Liu, Qian Chen, Dan‐dan Ruan et autres

BACKGROUND: Tubulointerstitial nephritis and uveitis (TINU) syndrome is prevalent among adolescent females and less prevalent among the older people. Additionally, although both disorders are linked to immune modulation, clinical instances of simultaneous diagnosis of TINU syndrome and monoclonal gammopathies (MG) are exceedingly …

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Overexpression of soybean flavonoid 3′-hydroxylase enhances plant salt tolerance by promoting ascorbic acid biosynthesis

Jianfei Wu, Xiaokun Wang, Jiawei Xu, Tongtong Li et autres

INTRODUCTION: Salt stress is a major cause of crop loss. Soybean (Glycine max), a globally vital legume crop, faces mounting yield constraints due to soil salinization. It is known that the flavonoid biosynthesis pathway involving flavonoid 3'-hydroxylase (F3'H) plays an important role …

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MiR-425-5p intervenes in autoimmune myocarditis by regulating Treg cell differentiation through NRAS

Shan Yu Zhou, Li Zhang, Xiuyun Duan, Keyu Liu et autres

Aim: Our Previous research revealed significant differences in exosome-mediated intercellular miR-425a-5p between normal children and those with fulminant myocarditis. We sought to elucidate the molecular underpinnings and functional implications of miR-425a-5p in the context of myocarditis progression. Methods: Bioinformatics techniques were employed …

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Epithelium intrinsic zinc sensor controls immune homeostasis with gut microbes via regulation of Tuft cell lineage

Rebecca Yunker, Geongoo Han, J. Velásquez Vasquez, Kellie Baldaro et autres

Abstract Zinc is an essential micronutrient crucial for cell proliferation, differentiation, and apoptosis, yet its precise role in the constantly renewing intestinal epithelium remains unclear. We generated mice lacking the Zn-dependent transcription factor Metal-responsive Transcription Factor 1(MTF1 ΔIEC ) in intestinal epithelial …

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