Jun‐Seok Lee

Fluorescence Turn-On Sensor for Gingipains: Selective Detection of Porphyromonas gingivalis in Periodontal Disease

Hira Aziz, Lizaveta Gotina, Yujeong Choi, Aizhan Abdildinova et autres

Porphyromonas gingivalis (P.g.), a key pathogen in periodontal disease, plays a critical role in bacterial invasion and is increasingly implicated in systemic conditions, including cardiovascular and neurodegenerative diseases. Its major virulence factors, gingipains, are cysteine proteases essential for pathogenicity. In this study, …

ye, kr, jp, us, pl (code pays fourni par la source)

Erlotinib-conjugated iridium(III) complexes for EGFR-mediated photodynamic therapy of cancer

Hey Young Yoon, Jung Hoon Lee, Jun‐Seok Lee

Abstract Photodynamic therapy (PDT) offers superior spatiotemporal control compared with conventional cytotoxic cancer therapies through localized light activation. However, most photosensitizers rely on passive tumor accumulation and lack intrinsic mechanisms for active cancer cell targeting. Here, we report Ir_Erl , the first …

kr, pr (code pays fourni par la source)

Membrane-mediated methods

Chiman Song, Jun‐Seok Lee, Eun Joo Roh, Sangbum Park

kr, pr, us (code pays fourni par la source)

Excited-State Intramolecular Proton Transfer Enables Self-Reporting Fluorescent Photoaffinity Labeling in Live Cells

Kostiantyn Kozoriz, Dhiraj P. Murale, Seong Cheol Hong, Kyung Tae Hong et autres

interactome profiling of aggregation-prone tau K18-P301L in HEK-Tau-BiFC reporter cells, which revealed eight cellular effectors of tau transmission, including four newly identified ones. ESIPT photochemistry thereby provides a minimally perturbing, self-reporting PAL platform for mapping intracellular interaction networks in their native environment.

kr, us (code pays fourni par la source)

Molecular Probes for Sulfatase Detection and Bio‐Imaging

Subba Rao Cheekatla, Seong Cheol Hong, Muresan Anca Raluca, Jun‐Seok Lee

Sulfatases are critical enzymes regulating the dynamic sulfation states of biomolecules and have profound implications in human physiology and pathology. Abnormal sulfatase activity is strongly connected to various diseases such as hormone-dependent cancers, infectious diseases like tuberculosis, lysosomal storage disorders, and bacterial …

kr, us, il, pr (code pays fourni par la source)

Dual effects of Korean red ginseng extract and its fractions on influenza A virus infectivity in lung-derived cell lines

Yevheniia Kharkivska, Dong Hoon Kim, Olha Shkel, Sun-Hak Lee et autres

kr, jp (code pays fourni par la source)

RNA aptamer-induced fluorescence enhancement for NADH monitoring in cellular environment

Mohammad Faysal Al Mazid, Syafira Rizqi Eskasalam, Jun‐Seok Lee

kr, jp (code pays fourni par la source)

Development of MDM2‐Targeting PROTAC for Advancing Bone Regeneration

Seongkeun Jeong, Jae‐Kook Cha, Wasim Ahmed, Minsup Kim et autres

Proteolysis-targeting chimeras (PROTACs) degrade target proteins through the ubiquitin-proteasome system. To date, PROTACs are primarily used to treat various diseases; however, they have not been applied in regenerative therapy. Herein, this work introduces MDM2-targeting PROTACs customized for application in bone regeneration. An …

kr, us (code pays fourni par la source)

Cholesterol sulfate as a negative regulator of cellular cholesterol homeostasis

Le Ba Nam, Sungjin Kim, Tấn Khanh Nguyễn, June‐Yong Lee et autres

Cholesterol sulfate (CS), one of the most abundant cholesterol derivatives, recently emerged as a key regulatory molecule in several physiological processes. Here, we demonstrate multiple mechanisms by which CS reduces intracellular cholesterol levels. CS promotes the proteasomal degradation of 3-hydroxy-3-methylglutaryl-CoA reductase reductase …

kr (code pays fourni par la source)

Correction to “A Pair of Fluorescent Probes Enabling Precise Diagnosis of Liver Cancer by Complementary Imaging”

Min Gao, Sun Hyeok Lee, Haw‐Young Kwon, Larissa Miasiro Ciaramicoli et autres

[This corrects the article DOI: 10.1021/acscentsci.4c01822.].

Combination of Aβ40, Aβ42, and Tau Plasma Levels to Distinguish Amyloid-PET Positive Alzheimer Patients from Normal Controls

Seungyeop Baek, Jinny Claire Lee, Byung Hyun Byun, Su Yeon Park et autres

Alzheimer disease (AD) diagnosis is confirmed using a medley of modalities, such as the detection of amyloid-β (Aβ) neuritic plaques and neurofibrillary tangles with positron electron tomography (PET) or the appraisal of irregularities in cognitive function with examinations. Although these methods have …

kr, us (code pays fourni par la source)

Distribution, abundance and grazing impact of Salpa fusiformis, with response to environmental conditions and their effects on other zooplankton species in Korean waters

Md Abidur Rahman Sourav, Seung Won Jung, Jun‐Seok Lee, Keun-Hyung Choi

Abstract The highly abundant pelagic tunicate Salpa fusiformis blooms in the Korean Peninsula. In this study, we examined the composition of mesozooplankton species and the environmental parameters in the S. fusiformis bloom areas in the East China Sea, the East Sea and …

kr (code pays fourni par la source)