Sang-Jin Lee

Extending Dual Antiplatelet Therapy Beyond 3 Months in Acute Ischemic Stroke Due to Large‐Artery Atherosclerosis

Minwoo Lee, Mi Sun Oh, Kyung‐Ho Yu, Byung‐Chul Lee et autres

BACKGROUND: The optimal duration of dual antiplatelet therapy (DAPT) with aspirin plus clopidogrel following acute ischemic stroke due to large-artery atherosclerosis remains uncertain. METHODS: We retrospectively analyzed data from a prospective, multicenter stroke registry (2011-2018) linked to a national health insurance claims …

kr, us (code pays fourni par la source)

VTA dopaminergic neuronal activity during NREM sleep is modulated by learning and facilitates motor memory consolidation

Bibi Alika Sulaman, Eric Chen, Aaron Crane, Sang-Jin Lee et autres

Memory consolidation enables animals to draw on past experiences to guide future behavior. This process involves system- and synaptic-level changes and predominantly occurs during sleep. While hippocampal-cortical circuits are well studied in this context, the contributions of other systems, including dopaminergic circuits—key …

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A Structural Path Analysis of Elder Abuse: Mediating Role of Depression in the Link between Multiple Hardships and Abuse Risk

Sang-Jin Lee, Yun Jeong Kim

This study analyzed the mediating effect of depression in the relationship between the four major hardships experienced by older adults—namely, physical illness, economic hardship, loneliness, and loss of social role—and their experience of elder abuse. Using data from the 6th National Survey …

gb, kr (code pays fourni par la source)

Connectivity-Based Analysis of the Stimulation Effects of Globus Pallidus Interna Deep Brain Stimulation in Parkinson’s Disease: A Focus on Freezing of Gait

Sungyang Jo, Sang-Jin Lee, Hwon Heo, Chong Hyun Suh et autres

OBJECTIVE: Freezing of gait (FOG) significantly affects quality of life and increases the risk of falls in patients with Parkinson's disease (PD). Although deep brain stimulation (DBS) of the globus pallidus interna (GPi) is effective in managing motor complications, its efficacy in …

kr (code pays fourni par la source)

Enhancing 3D dopamine transporter imaging as a biomarker for Parkinson’s disease via self-supervised learning with diffusion models

Grace Yoojin Lee, Sungyang Jo, Ji‐Hyun Lee, Sang-Jin Lee et autres

Accurate diagnosis and precise estimation of disease progression states are crucial for developing effective treatment plans for patients with parkinsonism. Although various deep learning-based computer-aided diagnostic models have demonstrated benefits, they have been relatively underexplored in parkinsonism owing to limited data and …

kr (code pays fourni par la source)

Medication versus globus pallidus internus deep brain stimulation in Parkinson’s disease with deep learning video analysis of finger tapping

Grace Yoojin Lee, K.W. Park, Sungyang Jo, Ji‐Hyun Lee et autres

In advanced Parkinson's disease (PD), considerable number of patients receive deep brain stimulation (DBS) surgery, to alleviate symptoms not readily controlled by medication. However, the differential effects of medication and DBS on improving motor symptoms, especially for DBS targeting the globus pallidus …

kr (code pays fourni par la source)

Baseline [18F]FP-CIT PET-based deep learning prediction of levodopa-induced dyskinesia in Parkinson’s disease

Grace Yoojin Lee, Jong-Man Won, Sungyang Jo, Ji‐Hyun Lee et autres

We aimed to develop a convolutional neural network (CNN) model with multi-task learning to predict the onset of levodopa-induced dyskinesia (LID) in patients with Parkinson’s disease (PD) using baseline [ 18 F]FP-CIT PET images. In this retrospective, single-center study, 402 patients were …

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Distinct gut microbiome characteristics and dynamics in patients with Parkinson’s disease based on the presence of premotor rapid-eye movement sleep behavior disorders

Jae‐Yun Lee, Sungyang Jo, Ji‐Hyun Lee, Ki-jeong Kim et autres

BACKGROUND: Alpha-synuclein aggregation, a hallmark of Parkinson's disease (PD), is hypothesized to often begin in the enteric or peripheral nervous system in "body-first" PD and progresses through the vagus nerve to the brain, therefore REM sleep behavior disorder (RBD) precedes the PD …

kr (code pays fourni par la source)

Mitochondrial DNA Copy Number as a Potential Biomarker for the Severity of Motor Symptoms and Prognosis in Parkinson's Disease

Sungyang Jo, Ji‐Hye Oh, Eun‐Jae Lee, Ji‐Hyun Lee et autres

BACKGROUND: Mitochondrial function influences Parkinson's disease (PD) through the accumulation of pathogenic alpha-synuclein, oxidative stress, impaired autophagy, and neuroinflammation. The mitochondrial DNA copy number (mtDNA-CN), representing the number of mitochondrial DNA copies within a cell, serves as an easily assessable proxy for …

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Susceptibility map-weighted MRI can distinguish tremor-dominant Parkinson’s disease from essential tremor

Sungyang Jo, Chong Hyun Suh, Sang-Jin Lee, Ji‐Hyun Lee et autres

Distinguishing between Parkinson’s disease (PD) and essential tremor (ET) can be challenging sometimes. Although positron emission tomography can confirm PD diagnosis, its application is limited by high cost and exposure to radioactive isotopes. Patients with PD exhibit loss of the dorsal nigral …

kr (code pays fourni par la source)

A Study on the Adoption of Digital Miranda Concepts to Ensure the Privilege Against Self-Incrimination

Kwan-Hee Lee, Sang-Jin Lee

대한민국헌법 제11조 제1항은 “모든 국민은 법 앞에 평등하다. 누구든지 성별･종교 또는사회적 신분에 의하여 정치적･경제적･사회적･문화적 생활의 모든 영역에 있어서 차별을 받지 아니한다.”라고 선언하고 있다. 대한민국의 형사소송구조는 당사자 대등주의를 취하고 있다. 그런데 과연 헌법이 선언한 바와 같이 법률지식의 유무, 경제적 상태의 격차에도 불구하고 차별없이 …

The Impact of Youth Addiction to Media Devices on Violent Behavior: Mediating Effect of Empathy and Moderated Mediating Effect of Gender

Sang-Jin Lee, Yun Jeong Kim

The purpose of this study was to determine the moderated mediating effect of gender in the effect of adolescents' media device addiction on violent behavior through empathy.Data from the 14th year of the Korean Children's Panel (PSKC) were used, and 1,301 first-year …

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