Fei Zhang

Immune infiltration-based prognostic signature for molecular subtyping and therapeutic stratification in lung adenocarcinoma

Jing Ren, Jiakun Gao, Shuhua Chen, Liming Liu et autres

The tumor immune microenvironment of lung adenocarcinoma (LUAD) is characterized by pronounced heterogeneity; however, practical tools capable of simultaneously dissecting its immunobiological characteristics and predicting therapeutic response remain scarce. Given the close association between immune infiltration-related genes and LUAD tumorigenesis, progression, and …

cn (code pays fourni par la source)

Exploratory early-warning modeling of in-hospital mechanical intestinal obstruction after kasai portoenterostomy in children with biliary atresia

Lili Yan, Yingying Zhu, Jushan Sun, Lin Yan et autres

Mechanical intestinal obstruction during hospitalization after Kasai portoenterostomy for biliary atresia (BA) is uncommon but clinically important. Because event numbers are limited and early manifestations overlap with postoperative ileus, this retrospective study aimed to identify perioperative early-warning signals and construct an exploratory, …

cn (code pays fourni par la source)

Integrative Bioinformatics Analyses Reveal X Chromosome Inactivation Escape Genes Dosage Dysregulation Is the Primary Contributor to Turner Syndrome.

Huisheng Liang, Zhongyang Li, Fei Zhang

Background: Turner syndrome is a rare disorder resulting from abnormalities in the number or structure of a single X chromosome. It stands as the sole survivable monosomy observed in humans. Individuals affected by Turner syndrome commonly face significant complications, including impaired gonadal …

cn, fr (code pays fourni par la source)

A large-scale single-cell atlas reveals the pulmonary immune panorama in adult patients with influenza

Kun Xiao, Y B Cao, Zhihai Han, Qian Da et autres

RATIONALE: The host immune determinants that distinguish protective from life-threatening responses to influenza are poorly understood. Identifying drivers of immunopathology in the human lung is critical for developing potential therapies. OBJECTIVES: To define the cellular and molecular immune landscape of the lung …

ph, cn, au, Ouganda, cz (code pays fourni par la source)

Surgeon experience and measurement method influence consistency of glenoid bone loss assessment: a three-dimensional printing, computed tomography, and arthroscopy comparison

Yuxin Xie, Shoulong Song, Fei Zhang, Ziang Li et autres

PURPOSE: To evaluate the accuracy of arthroscopic glenoid bone loss (GBL) assessment and its influencing factors, and to compare the consistency of three-dimensional computed tomography (3D CT) and 3D printed measurements. METHODS: 3D printed models were created from the 3D CT images. …

cn (code pays fourni par la source)

Exosomal EPHA2 transfers metastatic potential by stabilizing TGF-βRI and activating the TGF-β/SMAD3 signaling pathway in breast cancer

Liming Liu, Yichu Zhang, Xiaoxue Li, Yueni Mo et autres

OBJECTIVE: Intratumoral heterogeneity refers to the presence of distinct subpopulations of cancer cells within a single tumor, which exhibits variations in phenotypic traits, such as proliferation rate, drug sensitivity, and metastatic potential. Dynamic interactions among heterogeneous cell populations have a critical role …

cn (code pays fourni par la source)

Ginkgolide A alleviates LPS-induced alveolar epithelial cell injury by regulating the NOX4/Nrf2 pathway

Weijuan Hu, Xia Tao, Fei Zhang, Bin Liao

This study investigated the protective effects of Ginkgolide A (GA) against sepsis-induced lung injury and its underlying mechanisms. Human pulmonary alveolar epithelial cells (HPAEpiC) were stimulated with lipopolysaccharide (LPS) to establish an in vitro model of alveolar epithelial cell injury. The cells …

cn (code pays fourni par la source)

Hsa_circ_0003611 hinders the transformation of mesenchymal stem cells into osteosarcoma cells through suppressing MYC by IGF2BP3 via m6A modification

Fei Zhang, Fei Cheng, Zhi‐yong He, Chengyi Zhao

Abstract Background Osteosarcoma (OS) is the most common non-hematogenous primary malignancy in the bone. Due to several origins of OS, 30–40% OS patients would experience recurrence and metastasis, with a 5-year survival rate of 20–30%. Mesenchymal stem cells (MSCs) transform into OS …

cn (code pays fourni par la source)

Frailty as a predictor of postoperative outcomes in older gastroesophageal cancer patients: a systematic review and meta-analysis

Fei Zhang, Ying Yan, Baifeng Li, Chunlin Ge

BACKGROUND: Frailty disproportionately impacts older patients with cancer, rendering them at increased risk for poor surgical outcomes. However, the impact of frailty on postoperative outcomes in the population with older gastroesophageal cancer remains unknown. METHODS: Systematic review and meta-analysis of studies reporting …

cn (code pays fourni par la source)

Interaction of BPC1 and ALDH2 Affects Natural De-Astringency in Chinese PCNA Persimmon (Diospyros kaki)

Junchi Xu, Xia Li, Li Zhang, Fei Zhang et autres

Pollination-constant non-astringent (PCNA) persimmons have significant commercial value due to their natural de-astringency trait. The Chinese PCNA (C-PCNA) type is particularly valuable for genetic improvement because this trait is controlled by dominant genes. However, the regulatory mechanism underlying this trait remains unclear. …

cn (code pays fourni par la source)

Web-based integration of high-difficulty aerobics movements for real-time human activity recognition using fuzzy logic and big data analytics

Ze Ji, Mingsheng Xu, Fei Zhang, Zhang Ai et autres

cn (code pays fourni par la source)

Impact of claudin 18.2 expression on treatment outcomes of first-line immunochemotherapy in patients with HER2-negative, proficient MMR, PD-L1 CPS ⩾1 metastatic gastric/gastroesophageal junction cancer

Fei Zhang, Izuma Nakayama, Naoya Sakamoto, Dai Okemoto et autres

Background: The effect of claudin 18.2 (CLDN18.2) expression on the outcomes of a first-line immune checkpoint inhibitor (ICI)-containing chemotherapy (ICI-chemo) in patients with human epidermal growth factor receptor 2 (HER2)-negative, proficient mismatch repair (pMMR), and programmed death-ligand 1 (PD-L1)-expressing metastatic or recurrent …

jp (code pays fourni par la source)