Cong Ye

Anti-BCMA CAR T-cell for IgG4-related disease: is this necessary? – Authors' reply

Shaozhe Cai, Ziwei Hu, Yu Chen, Cong Ye et autres

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Immunomodulatory Hydrogel Coating with SeNPs and Lithium Silicate Synergistically Promotes Osseointegration and Prevents Infection on Titanium Implants

Su Jiang, Baisheng Cai, Cong Ye, Keyu Wu et autres

Effective osseointegration of implants remains a major challenge in biomaterials and regenerative medicine. In this context, restoring the disrupted microenvironment between the implant and bone tissue is critical, as it is primarily influenced by excessive ROS, infections, immune inflammatory reactions, and imbalances …

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Anti-BCMA CAR-T for the treatment of IgG4-related disease: clinical assessment and single-cell transcriptomic analysis

Shaozhe Cai, Yu Chen, Cong Ye, Umehara Hisanori et autres

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BCMA-targeted CAR T cell therapy can effectively induce disease remission in refractory lupus nephritis

Ziwei Hu, Shaozhe Cai, Yikai Yu, Yu Chen et autres

OBJECTIVES: This study aims to evaluate the safety and efficacy of anti-B cell maturation antigen (BCMA)-targeting chimeric antigen receptor (CAR) T cells in treating refractory lupus nephritis (LN). METHODS: This is an open-label, single-arm clinical trial assessing anti-BCMA CAR T cells in …

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Injectable natural Tremella-derived hydrogel for reversing ferroptosis-mediated osteoporotic microenvironment imbalance and promoting osteoregeneration

Cong Ye, Jiabao Xu, Lei Shi, Chaoyang Zong et autres

Osteoporotic bone defects constitute a global health predicament due to their restricted self-repairing capacity. Ferroptosis arising from iron overload represents a crucial pathological characteristic of osteoporosis, depleting osteoblasts and disturbing bone metabolism. Inspired by natural tremella polysaccharide (TP), we developed an injectable …

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Natural fish swim bladder-derived MPN-nanofibrous biomimetic system exhibit ECM-responsive signal regulation and promote robust tendon–bone healing

Lei Shi, Peng Zhou, Cong Ye, Jie Sun et autres

Enhanced tendon‒bone healing is of critically importance for achieving optimal postoperative recovery following a rotator cuff tendon tear (rotator cuff tears, RCTs). Although RCTs patch-augmented scaffolds demonstrate clinical potential, there is a paucity of reports on biodegradable scaffolds that effectively integrate high …

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IKZF1: An important target for the treatment of autoimmune diseases

Siyuan Bu, Cong Ye, Shaozhe Cai, Lingli Dong

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Effects of telitacicept in SLE patients with antiphospholipid antibody positivity: a retrospective self-controlled case series

Liling Zhou, Yong You, Shaozhe Cai, Cong Ye et autres

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Thalidomide can effectively prevent relapse in IgG4-related disease outweighing its side effects: a multicentre, randomised, double-blinded, placebo-controlled study

Yu Chen, Cong Ye, Pingting Yang, Wen Zhang et autres

OBJECTIVES: To investigate the effects of thalidomide in preventing disease relapse with 'zero' glucocorticoids (GCs) usage in IgG4-related disease (IgG4-RD). METHODS: This was a multicentre, randomised, double-blinded, placebo-controlled study, in which eligible patients in disease active status were randomised into 2 groups …

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Dysregulation and impaired anti-bacterial potential of mucosal-associated invariant T cells in autoimmune liver diseases

Wei J. Wang, Junmei Weng, Haoquan Zhang, Mi Wu et autres

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Machine-learning-based models assist the prediction of pulmonary embolism in autoimmune diseases: A retrospective, multicenter study

Ziwei Hu, Yangyang Hu, Shuoqi Zhang, Dong Li et autres

BACKGROUND: Pulmonary embolism (PE) is a severe and acute cardiovascular syndrome with high mortality among patients with autoimmune inflammatory rheumatic diseases (AIIRDs). Accurate prediction and timely intervention play a pivotal role in enhancing survival rates. However, there is a notable scarcity of …

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Supplementary Figures 1-7 from Host miR155 Promotes Tumor Growth through a Myeloid-Derived Suppressor Cell–Dependent Mechanism

Siqi Chen, Long Wang, Jie Fan, Cong Ye et autres

Supplemental Figure 1. Tumor growth in miR-155-deficient mice. Supplemental Figure 2. Host miR-155 deficiency enhanced antigen-specific antitumor T cell immunity. Supplemental Figure 3. miR-155 is required for optimal function of DCs and T cells from tumor-bearing mice. Supplemental Figure 4. miR-155 is …