Dongmei Wang

TEX264-mediated ER-phagy dysfunction contributes to Cadmium-induced ER stress: Implication of hippocampal neuronal apoptosis and cognitive deficits

Yufei Gao, Luyang Cao, Yibo Hong, Ke Hao et autres

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Inhibition of HSPA8 alleviates experimental autoimmune encephalomyelitis via dual modulation of NLRP3 inflammasome activation: suppressing both NF-κB–mediated priming and ASC-dependent assembly

Qianqian Bai, Yan Guo, Shunji Pan, F Liu et autres

The pathological processes of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are closely associated with excessive activation of inflammasomes. HSPA8 is a constitutively expressed molecular chaperone involved in cellular signaling and immune-inflammatory regulation, but its role in EAE-associated …

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AI-driven discovery of natural product-derived FAK1 inhibitors for idiopathic pulmonary fibrosis

Xing-Yi Chen, Mei‐Hong Lu, Bin Li, Ya Zhou et autres

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Ameliorative Effects of Urolithin A Against Cadmium-Induced NLRP3-Mediated Pyroptosis and Cognitive Deficits Via Regulating Aryl Hydrocarbon Receptor Signaling

Ying Zhu, Quan Yuan, Junhong Geng, Jieping Hu et autres

Cadmium (Cd) is an important environmental and industrial pollutant that induces neurotoxicity and neurobehavioral disorders in animals. Urolithin A (UA), a gut microbial-derived metabolite from polyphenolic compounds, exhibits potent neuroprotective effects in neurological disorders. Herein, we evaluated the ameliorative impact of UA …

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Multimodal Deep Learning for Retinal Disease Diagnosis

Dongmei Wang, Yuansong Cai, Wanli Qiao

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Liquid-liquid phase separation of ZHX2 protects DLBCL cells against ferroptosis through induction of SLC3A2

Juan Zhang, Dongmei Wang, Xiaomin Liu, Nana Wang et autres

Diffuse large B-cell lymphoma (DLBCL), the most common B-cell non-Hodgkin lymphoma (B-NHL), is characterized by strong aggression, high heterogeneity, and poor prognosis. Consequently, there is an urgent need to identify crucial therapeutic targets. Here, we found that the transcription factor zinc-finger and …

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Ameliorative effects of Urolithin A against Cadmium-induced NLRP3-mediated pyroptosis and cognitive deficits via regulating Aryl hydrocarbon receptor signaling

Ying Zhu, Quan Yuan, Junhong Geng, Jieping Hu et autres

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Identification and validation of NETs-related biomarkers in active tuberculosis through bioinformatics analysis and machine learning algorithms

Qi An, Rui Lin, Yi Tu, Chen Zhu et autres

Introduction: Diagnostic delays in tuberculosis (TB) threaten global control efforts, necessitating early detection of active TB (ATB). This study explores neutrophil extracellular traps (NETs) as key mediators of TB immunopathology to identify NETs-related biomarkers for differentiating ATB from latent TB infection (LTBI). …

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6-OR: The Effectiveness of Personalized Dietary Advice Based on CGM Data for Newly Diagnosed Patients with Type 2 Diabetes

Heng Wan, Na Yao, Zihao Gui, Dongmei Wang et autres

Introduction and Objective: Research on using electronic platforms to adjust diets for type 2 diabetes (T2D) patients with CGM data is scarce. This study aimed to evaluate the effectiveness of personalized dietary advice based on CGM data delivered through a digital platform …

1489-P: Associations between the Cardiovascular-Kidney-Metabolic Syndrome and Metabolic Dysfunction–Associated Steatotic Liver Diseasein U.S. and Chinese Populations

Heng Wan, Dongmei Wang, Zihao Gui, Na Yao et autres

Introduction and Objective: The American Heart Association (AHA) proposed the cardiovascular-renal-metabolic (CKM) syndrome in 2023 to address the interconnectedness of cardiovascular, renal, and metabolic diseases. The current study aimed to investigate the associations of metabolic dysfunction-associated steatotic liver disease (MASLD) and liver …

Ca2+ transfer via enhancing ER-Mito coupling contributed to BDE-47- induced hippocampal neuronal necroptosis and cognitive dysfunction

Junhong Geng, Quan Yuan, Chun‐Lin Ni, Yarong Zhang et autres

2,2,4,4-Tetrabromodiphenyl ether (BDE-47), a ubiquitous environmental pollutant, has gained increasing attention due to its high level in biological samples and potential neurotoxicity. Recent studies have indicated that the receptor interacting protein kinase 1 (RIPK1)-mediated necroptosis is implicated in BDE-47 cytotoxicity. However, little …

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Inflammatory and metabolic markers mediate the association of hepatic steatosis and fibrosis with 10-year ASCVD risk

Zihao Gui, Xingying Chen, Dongmei Wang, Zhi Chen et autres

BACKGROUND AND AIMS: Liver steatosis and fibrosis increase the predicted 10-year atherosclerotic cardiovascular disease (ASCVD) risk, though the roles of chronic inflammation and metabolic dysregulation remain unclear. This cross-sectional study quantitatively assesses this association and evaluates the mediating effects of metabolic dysregulation …

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