Di Wang

Niche-dependent immunometabolic regulation of tissue repair and regeneration

Xinchen Xie, Lingbin Zeng, Zhexu Chi, Di Wang

Tissue repair restores structural integrity and functional homeostasis after injury through coordinated interactions among immune cells, structural compartments, and extracellular matrix remodeling, ultimately culminating in tissue-resident regenerative programs. Increasing evidence indicates that this process is governed not only by protein-based regulatory cues …

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Dynamic regulation of lysine and arginine metabolism promotes immune evasion by limiting T cell function in cancer

Weiwei Yu, Ruya Sun, Xiaoyang Lu, Qiqi Deng et autres

Tumor cells promote metabolic dysregulation of immune cells by controlling the metabolic landscape of the tumor microenvironment. It is unclear whether tumors restrict specific nutrients to drive rapid growth and immune evasion in addition to the overconsumption of nutrients to support anabolism. …

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Natural killer cell-mediated immunosurveillance modulates liver cancer evolution through cancer stemness enhancement and lipid metabolism reprogramming

Liang Shi, Boqiang Liu, Ruya Sun, Jing He et autres

Tumor evolution enables liver cancer cells to acquire survival advantages and evade therapy-induced cell death. However, the role of natural killer (NK) cells in liver cancer evolution remains unclear. Here, we establish immune-humanized spatiotemporal liver cancer models and integrate single-cell, spatial transcriptomic, …

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Programmable Macrophage Mimics for Inflammatory Meniscus Regeneration via Nanotherapy

Xujie Lü, Zheng Ci, Bohui Li, Yajie Wang et autres

Meniscal injuries are common in the knee joint. Minor meniscal injuries usually respond well to conservative treatment, while severe cases often require complete meniscal replacement. Meniscal injuries cause inflammatory responses that importantly hinder meniscal tissue regeneration. Despite ongoing advances in research, considerable …

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P4-IDet: A Programmable Switch-Based Framework for Real-Time and High-Accuracy Traffic Anomaly Detection in ICPSs

Jiayu Luo, Zhengyan Zhou, Qinglai Tang, Xiang Chen et autres

The rise of Industry 4.0 exposes traditionally isolated Industrial Cyber-Physical Systems (ICPSs) to increasing network attacks, posing serious security threats and potential damage. Traffic anomaly detection is essential for identifying such attacks. Nevertheless, existing work faces a dilemma between high accuracy and …

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Integrating cross-sample and cross-modal data for spatial transcriptomics and metabolomics with SpatialMETA

Ruonan Tian, Ziwei Xue, Yicheng Qi, Jianliang Zhang et autres

Simultaneous profiling of spatial transcriptomics (ST) and spatial metabolomics (SM) on the same or adjacent tissue sections offers a revolutionary approach to decode tissue microenvironment and identify potential therapeutic targets for cancer immunotherapy. Unlike other spatial omics, cross-modal integration of ST and …

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Metabolic symphony coordinates the muscle regeneration niche

Zhexu Chi, Di Wang

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Spatiotemporal coordination between local flux and systemic homeostasis in the small intestine

Jian Zhang, Siwen Zhang, Lijun Du, Ying Zhao et autres

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WITHDRAWN: Natural Killer Cell-Mediated Immunosurveillance Drives Liver Cancer Evolution Through Cancer Stemness Enhancement and Lipid Metabolism Reprogramming

Liang Shi, Boqiang Liu, Ruya Sun, Jing He et autres

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WITHDRAWN: Natural Killer Cell-Mediated Immunosurveillance Drives Liver Cancer Evolution Through Cancer Stemness Enhancement and Lipid Metabolism Reprogramming

Liang Shi, Boqiang Liu, Ruya Sun, Jing He et autres

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Multi-courses of blinatumomab combined with reduced dose chemotherapy has been successfully used in chemo-intolerant middle to high-risk pediatric B-ALL patients with invasive fungal disease

En‐Min Zhou, Yongmin Tang, Chan Liao, Shupeng Lin et autres

Invasive fungal disease (IFD) remains a challenging complication and a leading cause of death in the treatment of childhood acute leukemia (AL). Blinatumomab is a novel bispecific antibody targeting CD19, with excellent anti-tumor effects against B cell malignancies, including B cell acute …

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Study on the role of miR-10b–3p as SASP in exosomes of premature senescent hepatocytes induced by hexavalent chromium

Liang Qi, Zidi Huang, Di Wang, Fei Xin et autres

The exact mechanisms through which chronic, low-concentration exposure to Cr(VI) facilitates the development of related pathological conditions remain to be fully elucidated. Senescence-associated secretory phenotype (SASP) exhibits a bidirectional regulatory function in biological processes. Consequently, it is essential to identify the formulation …

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