Xiaoting Zhang

CircZFYVE1 functions as a competitive endogenous RNA to enhance LSM14A-mediated antiviral defense against influenza A virus

Bingchen Qiao, Yiqing Zheng, Xiaoting Zhang, Menglu Fan et autres

Introduction: Circular RNAs (circRNAs) are covalently closed endogenous RNAs that regulate gene expression at the post transcriptional level and have been implicated in antiviral immunity. However, their functional roles and regulatory mechanisms during influenza A virus (IAV) infection remain incompletely defined. Methods: …

cn (code pays fourni par la source)

Probiotics in colorectal cancer: mechanisms, biomarkers, and adjunct strategies

Zihe Xu, Lan Mu, Hao Su, Xiaoting Zhang et autres

Colorectal cancer (CRC) is among the most common malignant tumors and remains a leading cause of cancer-related mortality worldwide. The gut microbiota and metabolites, which are modulated by host genetics and environmental exposures, have emerged as key contributors to the pathogenesis of …

hk, cn, gb (code pays fourni par la source)

Sec6 suppresses BoHV-1-triggered innate immunity through NDP52-mediated autophagic degradation of STING

Xiaoting Zhang, Wenqing Ma, Hongbin He, Hongmei Wang

cn (code pays fourni par la source)

RNA m 1 A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target

Xiaoting Zhang, Na Qin, Fenfen Ji, Hao Su et autres

Abstract Background The role of N1‐methyladenosine (m 1 A) in cancer is poorly understood. Here we explored the function of RNA methyltransferase TRNA methyltransferase 61A (TRMT61A) in colorectal cancer (CRC) and its potential as a therapeutic target. Methods RNA m 1 A …

hk, cn (code pays fourni par la source)

Identification and functional characterization of GmMACPF1 as a negative regulator of salt tolerance during germination

Zhiri Xu, Yajun Zhao, Xiaoting Zhang, Jie Huang et autres

1 Five elite salt-tolerant soybean germplasms were identified from 165 mutant lines, and 60 single nucleotide polymorphisms (SNPs) and five novel quantitative trait loci (QTLs) associated with salt tolerance were discovered. 2 Research demonstrated that GmMACPF1 functions as a negative regulator of …

cn (code pays fourni par la source)

Unlocking the therapeutic potential of disulfiram in sepsis: Mechanisms and future directions

Qi Wu, Wentao Ji, Xiaoting Zhang, Qingshuang Zhang et autres

The leading cause of mortality within ICUs is sepsis; however, treatment options typically fail to appropriately regulate the severely dysregulated host response to this syndrome. Recently, there has been an unexpected observation that the common alcoholic aversion treatment disulfiram has exhibited additional …

cn, se (code pays fourni par la source)

Nanoflower-structured MnO2/Au composites with enhanced catalytic performance for colorimetric assay of α-glucosidase

Xiaoting Zhang, Jiaqi Cao, Xiyu Chen, Ning Gan et autres

cn (code pays fourni par la source)

Phosphorylated Neuropeptides Regulate Glioblastoma Proliferation and Invasion via Chiral Amino Acids

Xueyin Hu, Xiaolin Duan, Yanying Li, Pin Wang et autres

Neuropeptides are endogenous neuromodulators that have been shown to play pivotal roles in cancer initiation and progression. The phosphorylation/dephosphorylation processes are critically involved in regulating the bioactivity of peptides. This study designed chiral phosphorylated neuropeptides with distinct modification sites to examine the …

cn, gb (code pays fourni par la source)

The pathogenesis and therapeutic strategies of heat stroke-induced endothelial injury

Shaokang Wang, Xiaoting Zhang, Yongqi Zhang, Nannan Wu et autres

Heat stroke is a severe and life-threatening condition characterized by elevated core body temperature and central nervous system dysfunction, often accompanied by multi-organ damage. The incidence and mortality of heat stroke are increasing due to global warming and more frequent heatwaves. This …

cn (code pays fourni par la source)

A “Cocktail” Fluorescent Probe for Multi‐ROS Imaging Unveils Ferroptosis‐Driven Liver Fibrosis Development

Hui Wang, Hongtong Wang, Tiancong Xiu, Xiaoting Zhang et autres

Abstract Liver fibrosis is a pathological repair response to chronic liver injury and may progress to cirrhosis, liver failure, or hepatocellular carcinoma if untreated. Currently, no approved therapies specifically target advanced liver fibrosis, thus exploring the molecular mechanisms underlying liver fibrosis has …

cn, me (code pays fourni par la source)

Author response for "Effective generation of heavy-atom-free triplet photosensitizers containing multiple intersystem crossing mechanisms based on deep learning"

Kepeng Chen, Xiaoting Zhang, Jike Wang, Dan Li et autres

A Novel Cranial Bone Transport Technique Repairs Skull Defect and Minimizes Brain Injury Outcome in Traumatic Brain Injury Rats

Shanshan Bai, Xuan Lu, Yan Xu, Han Su et autres

TBI (traumatic brain injury) is a major cause of mortality and morbidity among young adults with limited therapeutic strategies. Cranial bone transport (CBT) technique is a safe, less invasive, and relatively simple surgical technique in bone reconstruction, which has been used to …

hk, cn (code pays fourni par la source)