Huifang Li

Metagenomic analysis of viromes in surface seawater of Haizhou Bay, Lianyungang, China

Xiaoyuan Tian, Rongda Xiao, Yueting Wang, Huifang Li

Menin orchestrates corticogenesis via regulation of chromatin accessibility and activation of EphA4 in late-born neurons

Shuzhong Wang, Kai Zhuang, Liurong Chen, Dan Can et autres

The development of the mammalian cerebral cortex is tightly regulated by epigenetic mechanisms. However, the role of epigenetic modifications in gene regulation and their impact on neocortical function remain poorly understood. Here, we demonstrate that Menin, encoded by the multiple endocrine neoplasia …

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Trem2 regulates macrophage phenotype via the JAK2/STAT3 signaling pathway to ameliorate ventricular remodeling after acute myocardial infarction

Zefeng He, Jing Feng, Ru Yan, Peng Wu et autres

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Terminalia chebula Extract Alleviates Lipopolysaccharide‐Induced Acute Lung Injury by Modulating the Interleukin‐17‐Dependent Mitogen‐Activated Protein Kinase/Nuclear Factor‐Kappa B Signaling Pathways

Huifang Li, Shuguang Bao, Laxinamujila Bai, Zhiqiang Li et autres

Acute lung injury (ALI), a severe inflammatory disease, is intricately associated with the dysregulation of interleukin (IL)-17-mediated inflammatory responses. Terminalia chebula Retz., a traditional medicinal plant, can modulate inflammatory responses. We evaluated the effect of the prophylactic treatment using T. chebula extract …

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CDK3 induces neuronal death and brain atrophy in Alzheimer’s disease

Kai Zhuang, Zi Liu, Xiao Su, Hu Chen et autres

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Causal effects of ferroptosis-related traits on ovarian dysfunction: insights from integrating genome-wide Mendelian randomization, DNA methylation, gene expression, and proteome

Qun Zhou, Huifang Li, Yibo He, Hualiang Zhang et autres

BACKGROUND: Ferroptosis has been implicated in the development of ovarian dysfunction; however, the underlying causal genetic mechanisms remain largely unclear. In this study, a multi-omics Mendelian randomization (MR) approach was applied to systematically investigate the causal effects of ferroptosis-related molecular traits on …

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Triazine herbicides inhibit phytoplankton photosynthesis in the East China Sea: A species-specific assessment

Yaping Wu, Xiangyu Li, Peijian Ding, Huifang Li et autres

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Geniposide activates the NLRP3 inflammasome pathway to induce nephrotoxicity by regulating FXR/PERK/TXNIP pathways

Baoyue Liu, Zhinan Jin, Mingzhu Shi, Xuliang Hao et autres

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The UHPLC-Orbitrap MS/MS and Network Pharmacology Strategies Reveal the Active Antioxidants of Bleeding Sap from Sponge Gourd in Treating Tuberculosis

Di Zhang, Jiang Lu, Yujiang Dai, Xinxin Si et autres

The bleeding sap of Luffa cylindrica (L.) Roem has been used for the treatment of tuberculosis since the record of Supplements to Compendium of Materia Medica. The active components and possible mechanism of it are yet ambiguous. Hence, this study is focused …

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Radiative parameters of excited levels in Ce ii and Ce iii

Huifang Li, Wei Jia, Hongfeng Zheng, Zhenwen Dai

ABSTRACT Using the time-resolved laser-induced fluorescence technique, the radiative lifetimes for 34 levels from 31568.019 to 48657.336 cm−1 in Ce ii and 10 levels from 50043.85 to 63335.40 cm−1 in Ce iii were measured. To our best knowledge, 30 levels of Ce …

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Geniposide induces hepatotoxicity via the bile acid-induced activation of NLRP3 inflammasome and regulation of the FXR/PERK/TXNIP pathway

Zhinan Jin, Baoyue Liu, Yixuan Liu, Yanming Wei et autres

Gardenia jasminoides, as a widely used traditional Chinese medicine, excessive consumption of it may lead to severe liver injury. As the main hepatotoxic component in Gardenia jasminoides, the specific mechanism by which geniposide (GE) causes liver injury remains elusive. In this study, …

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Experimental and theoretical radiative parameters of some odd-parity levels in Tb III

Hongfeng Zheng, Yu Wang, Huifang Li, Q. N. Xu et autres

Natural radiative lifetimes of 19 odd-parity levels of Tb III in the energy range between 52,039 and 62,734 cm −1 were measured by the time-resolved laser-induced fluorescence method. To our knowledge, the lifetimes for 16 out of 19 levels were measured for …

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