Sheng Zhang

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen et autres

While Fgf and Hippo-Yap signaling are fundamental for proper development, homeostasis, and disease, their crosstalk remains largely unknown. Here, we identified that Yap and Taz, canonical Hippo effectors, function as noncanonical effectors of Fgf signaling to maintain the proper function of neural …

us, cn (code pays fourni par la source)

Piezoelectric co-electrospun composite scaffolds with ECM-mimicking structure and enhanced bioactivities for potential bone regeneration application

Xinyu Du, Yiran Li, Sheng Zhang, Gangqiang Zhang

cn (code pays fourni par la source)

AVIL promotes osteosarcoma progression and cisplatin resistance via ARP2/3-mediated DNA damage repair

Zhenyi Chen, Guozhu Tang, X Lv, Guoqing Ding et autres

• AVIL overexpression promotes osteosarcoma progression in vitro and in vivo , while AVIL deficiency exerted the inverse phenotypes. • AVIL interacts with the ARP2/3 complex to facilitate cisplatin resistance. • CK666, a inhibitor of the ARP2/3 complex, significantly reverses AVIL-mediated cisplatin …

cn (code pays fourni par la source)

A deep learning framework of static mechanical index for beam structures damage identification

Jiahuan Li, Li Zhu, Jinda Wang, Sheng Zhang et autres

cn (code pays fourni par la source)

Holdemanella biformis augments washed microbiota transplantation for the treatment of radiation enteritis

Weihong Wang, You Yu, Rui Wang, Yaxue Wang et autres

BACKGROUND: Current microbiome-based therapeutics face two prominent issues: the limited clinical efficacy of probiotics and the significant variability in the efficacy of microbiota transplantation across different diseases. Although washed microbiota transplantation (WMT) is a new faecal microbiota transplantation, a single therapeutic agent …

cn (code pays fourni par la source)

IDDF2025-ABS-0305 Breaking through the unidentified pathogen intestinal infections challenge: a nationwide exploration of washed microbiota transplantation

Sheng Zhang, Quan Wen, Faming Zhang

cn (code pays fourni par la source)

IDDF2025-ABS-0296 High-touch surfaces as hidden reservoirs of clostridioides difficile in endoscopic rooms: global burden trends and disinfection optimization from multicenter surveillance

Quan Wen, Sheng Zhang, Faming Zhang

cn (code pays fourni par la source)

IDDF2025-ABS-0317 Effectiveness and safety of washed microbiota transplantation on intestinal multidrug-resistant organisms: a nationwide retrospective study

Sheng Zhang, Quan Wen, Faming Zhang

cn (code pays fourni par la source)

Washed microbiota transplantation in refractory intestinal Behçet’s disease with trisomy 8/myelodysplastic features

Aoli Diao, Jie Xu, Rujun Ai, Sheng Zhang et autres

A 44-year-old woman, with refractory intestinal BD, trisomy 8 and MDS-like features, presented with progressive colonic ulcers and intractable abdominal pain. Over 20 months, nine pharmacological agents were discontinued due to toxicity or inefficacy, including thalidomide, lenalidomide, cyclophosphamide, cyclosporin, infliximab and so …

cn (code pays fourni par la source)

Early-warning signals and the role of H9N2 in the spillover of avian influenza viruses

Yanhe Wang, Jinjin Chen, Jun Ma, Jonathan E Owen et autres

BACKGROUND: The spillover of avian influenza viruses (AIVs) presents a significant global public health threat, leading to unpredictable and recurring pandemics. Current pandemic assessment tools suffer from deficiencies in terms of timeliness, capability for automation, and ability to generate risk estimates for …

cn, us (code pays fourni par la source)

Identification of NIBAN2‐Regulated RUNX2 Alternative Splicing Presents Novel Strategies for Antagonizing Osteoporosis

Sheng Zhang, Zhiqiang Yang, Yuanlong Xie, Yufeng Zhang et autres

Osteoporosis is characterized by excessive bone resorption and/or defects in bone formation. Identification of factors promoting osteoblast differentiation may provide potential targets for osteoporosis therapy. Through integral analyses of multiple datasets, NIBAN2 is found to be tightly associated with bone formation and …

cn (code pays fourni par la source)

Post‐Thrombectomy Mild Hypercapnia State Prevents Poor Outcome by Reducing Infarct Progression

Weitao Yu, Xu Wang, Yu Geng, Qiang Shen et autres

Abstract Objective In endovascular therapy (EVT) for stroke, futile recanalization contributes to poor prognosis. Mild hypercapnia may enhance cerebral blood flow and prevent ischemia, but its impact on prognosis in successfully recanalized EVT patients is unclear. Methods We retrospectively analyzed 237 patients …

cn, au (code pays fourni par la source)