Yi Zhang

Multi-omics analysis of the potential of MACC1 as a biomarker and therapeutic target for colonic adenocarcinoma

Zhenkun Chen, Chun Zheng, Yi Zhang, Xulin Peng et autres

Abstract Colonic adenocarcinoma (COAD) is a major cause of cancer-related mortality worldwide. Various tumors are linked to metastasis-associated in colon cancer 1 (MACC1). This study aimed to analyze public datasets to examine MACC1 expression, signaling pathways, copy number variations, and associations with …

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Modified stress hyperglycemia ratio identifies the risk of early cardiovascular complications in patients with acute myocardial infarction

Yi Zhang, Jiahao Duan, Huang Fan, Kai Huang et autres

Background: Stress hyperglycemia ratio (SHR) has been associated with poor outcomes in patients with acute myocardial infarction (AMI). Modified SHR (mSHR) is defined as the highest SHR observed within the first 24 h of admission. However, the association between mSHR and early …

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Abstract P4-11-04: Correlative analysis of Breast Cancer Index with Body Mass Index for prediction of extended endocrine therapy benefit in the BCI Registry study

Natalia Siuliukina, B O'Neal, Amanda K. L. Anderson, Yi Zhang et autres

Abstract Background: Hormone receptor-positive (HR+) breast cancer patients derive only modest benefit from extended endocrine therapy (EET) while facing an increased risk of late distant recurrence (DR). The Breast Cancer Index (BCI) is a validated genomic assay for providing individualized risk of …

Abstract P1-11-07: Associations between Breast Cancer Index Classifications and MSK-IMPACT Genomic Profiles in HR+/HER2- Breast Cancer

Hong Zhang, Li Ma, Anton Mikhailovich Safonov, Natalia Siuliukina et autres

Abstract Background: The Breast Cancer Index (BCI) is a gene expression-based signature that stratifies patients based on the risk of overall (0-10 years) and late (post-5 years) distant recurrence (DR). BCI also predicts the likelihood of benefit from extended endocrine therapy in …

Reliability and validity testing of Chinese version of the Salmon's item List

CHEN Rui, YANG Jiaxun, NI Yisha, LI Hailin et autres

ObjectiveTo translate the German version of the Salmon's item List（SIL⁃Ger）into Chinese，and evaluate its reliability and validity，which aims to provide our country with an effective tool to more easily measure the maternal experience of childbirth.MethodsIn pursuant to the Brislin model，the SIL⁃Ger was translated，back⁃translated，cross⁃cultural …

Ulotaront, a Trace Amine-Associated Receptor 1/Serotonin 5-HT 1A Agonist, in Patients With Parkinson Disease Psychosis

Stuart Isaacson, Rajesh Pahwa, Carlos Singer, Kevin J. Klos et autres

Background and Objectives Ulotaront (SEP-363856) is a trace amine-associated receptor 1 agonist with 5-HT1A receptor agonist activity currently in phase 3 clinical development for the treatment of schizophrenia. In this exploratory, flexibly dosed study, ulotaront was evaluated for the treatment of Parkinson …

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Data from Breast Cancer Index Is a Predictive Biomarker of Treatment Benefit and Outcome from Extended Tamoxifen Therapy: Final Analysis of the Trans-aTTom Study

John M.S. Bartlett, Dennis C. Sgroi, Kai Treuner, Yi Zhang et autres

AbstractPurpose: The Breast Cancer Index (BCI) HOXB13/IL17BR (H/I) ratio predicts benefit from extended endocrine therapy in hormone receptor–positive (HR+) early-stage breast cancer. Here, we report the final analysis of the Trans-aTTom study examining BCI (H/I)'s predictive performance. Experimental Design: BCI results were …

Influence of education level on MMSE and MoCA scores of elderly inpatients

Yehuan Wu, Yi Zhang, Xiaofang Yuan, Jing Guo et autres

Objective The purpose of this study was to investigate the influence of education level on MMSE and MoCA scores of elderly inpatients.Method This is a cross-sectional study. A total of 260 elderly inpatients were evaluated by the MMSE and MoCA sequentially.Results The …

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HER2 status and prediction of extended endocrine benefit with breast cancer index (BCI) in HR+ patients in the adjuvant tamoxifen: To offer more? (aTTom) trial.

John M.S. Bartlett, Dennis C. Sgroi, Kai Treuner, Yi Zhang et autres

522 Background: BCI is a validated gene expression-based assay that stratifies patients based on risk of overall (0-10y) and late (post-5y) distant recurrence (DR) and predicts likelihood of benefit from extended endocrine therapy (EET). The Trans-aTTom study established Level1B validation for BCI …

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Clinical value of different anti-D immunoglobulin strategies for preventing Rh hemolytic disease of the fetus and newborn: A network meta-analysis

Xiaohui Xie, Qiurong Fu, Ziwei Bao, Yi Zhang et autres

BACKGROUND: Several anti-D immunoglobulin strategies exist for preventing Rh hemolytic disease of the fetus and newborn. This study systematically assessed the clinical value of those therapeutic strategies. METHODS: The Web of Science, PubMed, EMBASE, China National Knowledge Infrastructure (CNKI) and Wanfang databases …

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Prognostic value of lncRNA FEZF1 antisense RNA 1 over-expression in oncologic outcomes of patients with solid tumors

Yi Zhang, Qiuxi Yang, Tingting Peng, Lijuan Wang et autres

BACKGROUND: FEZ family zinc finger 1 antisense RNA 1 (FEZF1-AS1), as a novel lncRNA, was reported to be up-regulated in various cancers and involved in tumor progression. This study systematically assessed the prognostic value of FEZF1-AS1 in solid tumors. METHODS: Web of …

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Prognostic utility and clinical significance of lysyl oxidase‐like 2 protein expression in digestive system cancers

Yi Zhang, Wanwei Liu, Jiwei Xu

Lysyl oxidase-like 2 (LOXL2) participates in the occurrence and development of digestive system cancers (DSCs). The aim of this study was to determine whether LOXL2 protein could serve as a prognostic biomarker in patients with DSCs. Relevant studies published before October 1, …

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