Yucheng Zhang

Non-coding RNAs in tumor-educated platelets: emerging roles in cancer progression, biomarker discovery, and therapeutic targeting

Yaning Liu, Yucheng Zhang, Dongni Li, Jian Zhao et autres

Non-coding RNAs (ncRNAs) in tumor-educated platelets (TEPs) play an important role in cancer progression. Tumor cells can “educate” platelets, thereby enabling them to participate in multiple stages of tumor development and progression. The ncRNAs carried by TEPs, including microRNAs (miRNAs), circular RNAs …

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Effects of dietary fucoidan and exercise on the gut microbiome, fecal metabolome, and tumor-related responses in a murine colorectal cancer model

Lin Zhong, Bhagyalakshmi Purushothaman, Xingxiang Wang, Yucheng Zhang et autres

Dietary fucoidan, a sulfated polysaccharide derived from brown seaweed, has attracted increasing interest for its potential to influence gut microbial and metabolic responses. However, the individual and combined effects of dietary fucoidan and exercise on host–microbiome interactions during colorectal cancer development remain …

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Exosomal circRNAs in hepatocellular carcinoma: Implications for the development and therapeutic resistance of hepatocellular carcinoma (Review)

Zhiyao Liu, Yuqiao Wang, Yali Wang, Yucheng Zhang

Hepatocellular carcinoma (HCC) is the predominant type of primary liver cancer, with high morbidity and mortality rates globally, ranking it among the leading causes of cancer‑related death worldwide. Despite notable advancements in HCC treatment in recent years, high rates of recurrence and …

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Metabolic reprogramming and immune regulation in acute myeloid leukemia

Xiaogang Hao, Chenyang Fan, Lixiang Yan, Reaila Jianati et autres

The most prevalent kind of acute leukemia in adults is acute myeloid leukemia (AML). While some individuals have had better effectiveness due to advancements in targeted medications, recurrence after remission and inadequate treatment specificity continue to be significant therapeutic problems. By controlling …

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Targeting TBK1 potentiates oncolytic virotherapy via amplifying ICAM1-mediated NK cell immunity in chemo-resistant colorectal cancer

Xin Guo, Huolun Feng, Zhihui Xi, Ji Zhou et autres

BACKGROUND: Tumor resistance is the primary reason for treatment failure in patients with cancer, while oncolytic viruses (OVs), as a novel therapy, have been rapidly advancing through clinical evaluation and are typically assessed in recurrent tumors that are refractory to standard chemotherapy. …

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Berberine Ameliorates Pulmonary Fibrosis by Inactivating the Thrombospondin 2/Smad Homolog 2/3 Pathway

Liwen Zhang, Jie Chen, Xiang Huang, Yucheng Zhang et autres

Pulmonary fibrosis (PF) is a progressive and irreversible lung disease. Previous studies have shown that berberine (BBR) ameliorates PF; however, the mechanism of BBR regulating PF remains unclear. mRNA expression of thrombospondin 2 (THBS2) was analyzed by quantitative real-time polymerase chain reaction. …

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Integrative analysis of bulk and single-cell sequencing reveals TNFSF9 as a potential regulator in microsatellite instability stomach adenocarcinoma

Jianlong J. Zhou, Yucheng Zhang, Yongfeng Liu, Jiehui Li et autres

BACKGROUND: Stomach adenocarcinoma (STAD) with microsatellite instability (MSI) is associated with a better prognosis compared to Non-MSI. This study aims to elucidate the differences in the tumor microenvironment (TME) of MSI and explore its underlying mechanisms in STAD. METHODS: TME differences between …

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Integrated analysis of single-cell and bulk RNA-sequencing to predict prognosis and therapeutic response for colorectal cancer

Liyang Cai, Xin Guo, Yucheng Zhang, Huajie Xie et autres

Colorectal cancer (CRC) is a prevalent malignant tumor characterized by high global incidence and mortality rates. Furthermore, it is imperative to comprehend the molecular mechanisms underlying its development and to identify effective prognostic markers. These efforts are crucial for pinpointing potential therapeutic …

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LGALS9B stabilizes EEF1D protein and activates the PI3K/AKT signaling pathway to promote gastric cancer occurrence and metastasis

Huolun Feng, Weiwei Yao, Yucheng Zhang, Yongfeng Liu et autres

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Sex-specific association between platelet content and bone mineral density in adults: a cross-sectional study

Yucheng Zhang, Zhendong Huang, Juan Xie, Xinli Zhou et autres

BACKGROUND: Osteoporosis (OP) is a complex skeletal disorder characterized by reduced bone mass, microarchitectural deterioration of bone tissue, and increased susceptibility to fractures. Bone mineral density (BMD), as the best indicator of bone mineral content per unit area of bone, is one …

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Redox-Detecting Deep Learning for Mechanism Discernment in Cyclic Voltammograms of Multiple Redox Events

Benjamin B. Hoar, Weitong Zhang, Yuanzhou Chen, Jingwen Sun et autres

High Resolution Image Download MS PowerPoint Slide In electrochemical analysis, mechanism assignment is fundamental to understanding the chemistry of a system. The detection and classification of electrochemical mechanisms in cyclic voltammetry set the foundation for subsequent quantitative evaluation and practical application, but …

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MSGFormer: Revolutionizing Traffic Flow Prediction With Multiscale and Gated Transformer Architecture

Wei Li, Yucheng Zhang, Ruijin Sun, Shiming Xia et autres

Traffic flow prediction has emerged as a critical component in advancing smart cities. Nevertheless, precisely forecasting traffic flow remains a formidable challenge, attributable to the intricate and dynamic spatiotemporal interdependencies inherent within traffic data. Contemporary methodologies often overlook the different impacts exerted …

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