Jianfeng Zhang

Persistent asymptomatic eosinophilia after raw seafood exposure with normal IgE: a case report

Wen He, Juzhang Li, Jianfeng Zhang, Qiaozhen Wu

spp.]) may cause gastrointestinal and allergic manifestations. Here, we report an unusual case of persistent, asymptomatic peripheral eosinophilia following ingestion of raw or lightly marinated seafood, raising the possibility of subclinical antigenic stimulation. The patient remained entirely asymptomatic with normal total IgE …

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Knocking Out Two Polyphenol Oxidase Genes Significantly Improves Recombinant Protein Purification in Nicotiana benthamiana

Hai‐Ping Diao, Hao Meng, Xuejiao Xu, Zeng‐Lin Zhang et autres

Efficient purification remains a key technical challenge affecting the recovery efficiency of recombinant proteins in plant-based systems. Complex metabolites, particularly polyphenols, often cause recombinant protein aggregation during purification. In this study, we identified two key polyphenol oxidase genes, PPOa and PPOb from …

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Efficacy and safety of fractional CO2 laser therapy combined with triamcinolone acetonide injection for hypertrophic scar: a preliminary systematic review and meta-analysis

Jianfeng Zhang, Min Wu, Cong Liu, Xiaochen Zhu et autres

Background This study aims to systematically evaluate the efficacy and safety of fractional CO 2 laser therapy combined with triamcinolone acetonide (TA) injection for hypertrophic scar (HS). Materials and methods Randomized controlled trials (RCTs) investigating the combination therapy of fractional CO₂ laser …

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MICA-129 Met/Met contributes to the susceptibility of colorectal cancer

Jingxin Ye, Renan Chang, Jianfeng Zhang, Fei Qian et autres

The highly polymorphic human major histocompatibility complex class I chain-related gene A (MICA) regulates immune surveillance and destroys tumor cells by activating its receptor, the natural killer group 2D. This study aimed to examine a single nucleotide polymorphism of this gene at …

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Duhuo Jisheng decoction alleviates intervertebral disc degeneration by inhibiting nucleus pulposus cell pyroptosis via gallic acid-mediated downregulation of HIF-1α

Junjie Cheng, Jianjun Li, Cheng Jun Yu, Wenhao Kuang et autres

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Machine Learning Analysis of Retrospective Data From 503 Hospitalized Older Patients With Type 2 Diabetes to Identify Factors Associated With Cognitive Impairment

Mingzhu Yu, Jianfeng Zhang, Guoran Li

BACKGROUND Diabetes is increasingly prevalent among older adults; mild cognitive impairment (MCI) comorbidity in this group represents a major concern. Existing MCI prediction methods are often inaccurate, but machine learning (ML) offers improved potential. This study aimed to identify factors associated with …

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Single-cell sequencing analysis reveals CHURC1 as a non-canonical oncoprotein governing goblet cell-driven colorectal tumorigenesis

Fei Qian, Min Jiang, Weilin Pu, Jianfeng Zhang et autres

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Graphene oxide-based membranes: Recent advances in ionic and molecular resource recovery

Ziming Zheng, Mengni Ge, Jianfeng Zhang, Yuhui Wang et autres

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Duhuo Jisheng decoction alleviates intervertebral disc degeneration via the acacetin-mediated MAPK1/HMOX1 axis by inhibiting nucleus pulposus cell pyroptosis

Cheng Jun Yu, Jianjun Li, Junjie Cheng, Zhihui Zhou et autres

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Natural Flavonoid Nobiletin Attenuates Allergic Asthma via Suppression of STAT3 / PI3K ‐ AKT and Neutrophil Extracellular Traps

He Wen, Yuqing Xu, Lin Zhu, Juzhang Li et autres

Allergic asthma is classically defined by eosinophilic inflammation and Th2 immune responses. However, neutrophils are increasingly recognized as key contributors, particularly through the release of neutrophil extracellular traps (NETs), which exacerbate airway inflammation by promoting antigen presentation and amplifying Th2 responses. Recent …

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Ultrasound triggered spatial-temporal NO gas release to enhance sonodynamic therapy and immune checkpoint blockade therapy against pancreatic cancer

Wanrui Shi, Jianfeng Zhang, Ruiqi Wu, Shiti Shama et autres

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Machine learning based screening of biomarkers associated with cell death and immunosuppression of multiple life stages sepsis populations

Jie Yang, Fang‐Shu Ou, Binbin Li, Lixiong Zeng et autres

Sepsis is a condition resulting from the uncontrolled immune response to infection, leading to widespread inflammatory damage and potentially fatal organ dysfunction. Currently, there is a lack of specific prevention and treatment strategies for sepsis across different age groups. Programmed Cell Death …

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