Yu‐Wei Chen

Investigation of ED4 supplementation on cardiovascular parameters in rats with elevated systemic TMAO

Yiting Qiu, Ping‐Hsiu Huang, Yu‐Wei Chen, Ming‐Kuei Shih et autres

Trimethylamine-N-oxide (TMAO), an intestinal microbiota-derived metabolite, is strongly linked to metabolic disorders, cardiovascular diseases, and liver injury. This study aimed to evaluate the therapeutic effects of 3-O-butanoylresveratrol (ED4), a resveratrol derivative, in a rat model with elevated systemic TMAO induced via osmotic …

tw, ye (code pays fourni par la source)

Bridging or Direct Thrombectomy in Posterior Circulation Large-Vessel Occlusion Stroke

Chih‐Hao Chen, Yong Soo Kim, Chung‐Wei Lee, Chung Liang Chai et autres

BACKGROUND AND OBJECTIVES: The role of IV thrombolysis before endovascular thrombectomy (bridging thrombectomy, BT) in posterior circulation large-vessel occlusion stroke remains uncertain. This study evaluated the effectiveness and safety of BT compared with direct thrombectomy (DT) using data from 2 nationwide registries …

tw, kr, Nigéria, Éthiopie (code pays fourni par la source)

Environmental Nephrotoxicity Across the Life Course: Oxidative Stress Mechanisms and Opportunities for Early Intervention

Chien‐Ning Hsu, Chih‐Yao Hou, Yu‐Wei Chen, Guo‐Ping Chang‐Chien et autres

Chronic kidney disease (CKD) affects nearly 10% of the global population, ranks among the top ten causes of death, and often progresses silently to end-stage disease without timely intervention. Increasing evidence indicates that many adult-onset cases originate in early life through adverse …

tw (code pays fourni par la source)

Impact of Maternal High-Fat Diet on Offspring Cardiovascular–Kidney–Metabolic Health: Spotlight on Oxidative Stress

Chien‐Ning Hsu, Chih‐Kuang Chen, Chih‐Yao Hou, Yu‐Wei Chen et autres

Cardiovascular-kidney-metabolic syndrome (CKMS) encompasses interconnected cardiovascular, renal, and metabolic disorders, including obesity, hypertension, and type 2 diabetes. Oxidative stress is increasingly recognized as a central driver of this multi-organ dysfunction. Among maternal influences, exposure to a high-fat diet (HFD) during pregnancy and …

tw (code pays fourni par la source)

Triglyceride-glucose index and related parameters in the diagnosis and predictive efficacy for older adults with NAFLD/MASLD: a prospective cohort study

Yu‐Wei Chen, Xinjun Lin, Yanqiu Chen, Bingcai Wang et autres

Background Non-alcoholic fatty liver disease (NAFLD) affects over 25% of the global population and is associated with numerous comorbidities. Several indices, including the triglyceride-glucose (TyG) index, TyG-waist circumference (TyG-WC), TyG-body mass index (TyG-BMI), and TyG-waist-height ratio (TyG-WHtR), have been strongly associated with …

cn (code pays fourni par la source)

Alpha-linolenic acid protects against heatstroke-induced acute lung injury by inhibiting ferroptosis through Nrf2 activation

Lin Wang, Jiamin Ma, Zhaozheng Li, Ying Chen et autres

Heatstroke (HS)-induced acute lung injury (ALI) has high morbidity and mortality with no specific therapies. Ferroptosis, a form of programmed cell death driven by lipid peroxidation due to reduced Glutathione Peroxidase 4 (GPX4) activity, is closely linked to HS-induced ALI. This study …

cn (code pays fourni par la source)

Investigation of ED4 supplementation on cardiovascular parameters in rats with elevated systemic TMAO

Yiting Qiu, Ping‐Hsiu Huang, Yu‐Wei Chen, Ming‐Kuei Shih et autres

ye, tw, cn (code pays fourni par la source)

Attributable burden of steatotic liver disease on cardiovascular outcomes in Asia

Szu‐Ching Yin, Yi-Ting Chen, Wei‐Ting Chang, Tzu-I Chen et autres

Background & Aims: The associations between metabolic dysfunction-associated steatotic liver disease (MASLD) and specific cardiovascular events, as well as their attributable burdens, remain inconsistent and underexplored within a single population. This large-scale prospective cohort evaluated the associations between MASLD and various cardiovascular …

tw (code pays fourni par la source)

Activity and mechanism of sea cucumber intestinal peptides in protecting and repairing gastric mucosa

Xiaofei Sun, Yu‐Wei Chen, Guorui Luo, Jingyu Hu et autres

This study investigated the protective and reparative effects of sea cucumber intestinal peptides (SCIPs) against ethanol-induced damage in human gastric mucosal epithelial cells (GES-1 cells) and explored the underlying mechanisms. SCIPs alleviated oxidative stress by reducing ROS levels, increasing SOD activity, and …

sg, cn (code pays fourni par la source)

Serial Examination of Platelet Function Tests Might Predict Prognosis of Patients with Acute Ischemic Stroke—A Cohort Study

Hsin-Ju Ho, Li-Ching Wu, Yu‐Wei Chen

Background: This study investigated whether point-of-care platelet function measurements could predict favorable outcomes in patients with acute ischemic stroke (AIS). Antiplatelet agents, such as aspirin, are known to reduce the risk of recurrent stroke by 20–30%. However, identifying nonresponders to therapy remains …

tw (code pays fourni par la source)

Prevalence, proportions of elevated liver enzyme levels, and long‐term cardiometabolic mortality of patients with metabolic dysfunction‐associated steatotic liver disease

Yi‐Ting Chen, Tzu‐I Chen, Szu‐Ching Yin, Chia‐Wei Huang et autres

Abstract Background and Aim This study estimated the prevalence of metabolic dysfunction‐associated steatotic liver disease (MASLD) according to cardiometabolic risk factors. The long‐term impacts of MASLD on all‐cause and cardiometabolic‐specific mortality were evaluated. Methods We enrolled 343 816 adults aged ≥30 years …

tw (code pays fourni par la source)

A composite score based on cardiovascular parameters can predict the mortality risk of patients with newly diagnosed interstitial lung disease: A prospective observational study

Yu‐Wei Chen, Chih‐Hung Lai, Yu-Wan Liao, Ming-Cheng Liu et autres

tw (code pays fourni par la source)