Chun‐Hua Wang

Tazarotene-Induced Gene 2 Promotes Melanoma Cell Death via the Activation of Endoplasmic Reticulum Stress

Chun‐Hua Wang, Lu‐Kai Wang, Fu‐Ming Tsai

Background:Tazarotene-induced gene 2 (TIG2), also known as retinoic acid receptor responder 2 (RARRES2), encodes the secreted protein TIG2, also known as chemerin, which is involved in immune regulation and metabolism. However, its role in melanoma remains unclear. Methods:TIG2 expression was analyzed using …

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Tazarotene-Induced Gene 3 (TIG3) Induces Apoptosis in Melanoma Cells Through the Modulation of Inhibitors of Apoptosis Proteins

Chun‐Hua Wang, Lu‐Kai Wang, Fu‐Ming Tsai

Background/Objectives: Retinoic acid has been shown to inhibit melanoma progression; however, its underlying mechanisms remain unclear. In this study, we investigated the role of the retinoic acid-inducible gene TIG3 in regulating melanoma cell growth, as well as elucidating its involvement in apoptosis. …

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Interleukin-18 (IL-18) engineered for half-life extension and resistance to IL-18 binding protein (IL-18BP) to enhance anti-cancer therapeutic potential

Kristiana Dreaden, Su-Ping Pearson, Pinar S. Gurel, Robert G. Newman et autres

Recombinant interleukin-18 (IL-18) holds promise as a therapeutic for oncology, as a robust activator of adaptive and innate immune cells and a potent producer of IFN-γ. However, clinical success has been limited due to rapid upregulation of the natural IL-18 inhibitor, IL-18 …

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A Novel Role for Tazarotene-induced Gene 1 in Suppressing Melanoma Growth — Schlafen 11

Chun‐Hua Wang, Lu‐Kai Wang, Fu‐Ming Tsai

IMR Press is a leading publisher of open access peer-reviewed biomedical and life sciences journals. We aim to facilitate the dissemination of high-quality research in the area of biomedical science. With a long tradition and wide readership, IMR Press is dedicated to …

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Exploring Potential Therapeutic Applications of Tazarotene: Gene Regulation Mechanisms and Effects on Melanoma Cell Growth

Chun‐Hua Wang, Lu‐Kai Wang, Fu‐Ming Tsai

Tazarotene, a retinoid derivative, is widely used in treating skin conditions such as psoriasis and acne. Recent studies have demonstrated its potential as a promising therapeutic agent for treating melanoma in situ. Its primary mechanism of action involves the selective activation of …

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1340 Preclinical efficacy and immune activity of half-life extended IL-18 fusion proteins resistant to IL-18BP suppression

Mark Whitmore, Kristiana Dreaden, Pinar S. Gurel, Joshua Heiber et autres

Background The promising immunological effects of recombinant wild-type interleukin-18 (IL-18) for cancer immunotherapy have been limited in clinical studies by rapid upregulation of IL-18 binding protein (IL-18BP), which serves as a negative feedback checkpoint of the IL-18 pathway. Additionally, cytokines are rapidly …

Abstract 4076: Interleukin-18 engineered for resistance to IL-18 binding protein (IL-18BP) and half-life extension to enhance its therapeutic potential

Jean Chamoun, Clifford DiLea, Kristiana Dreaden, Pinar S. Gurel et autres

Abstract Interleukin-18 (IL-18) possesses a unique combination of innate and acquired immune functions with high potential to be transformative in cancer immunotherapy of solid tumors. In clinical studies, recombinant wild-type IL-18 was limited by rapid upregulation of IL-18 binding protein (IL-18BP), which …

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Methanol Extract of Peach Kernel Induces Human Hair Follicle Dermal Papilla Cell Proliferation via the Extracellular Signal-Regulated Kinase Signaling Pathway

Fu‐Ming Tsai, Ping‐Hsun Lu, Lu‐Kai Wang, Chan‐Yen Kuo et autres

Hair loss is a common symptom in dermatology. While it is not fatal, it can significantly affect an individual's mental well-being. There are many products derived from traditional Chinese medicine formulas on the market that advertise the efficacy of hair growth and …

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TIG1 Inhibits the mTOR Signaling Pathway in Malignant Melanoma Through the VAC14 Protein

Chun‐Hua Wang, Chang‐Chieh Wu, Mao‐Liang Chen, Chan‐Yen Kuo et autres

BACKGROUND/AIM: Currently, there are few drug options available to treat malignant melanoma. Tazarotene-inducible gene 1 (TIG1) was originally isolated from skin tissue, but its function in skin tissue has not been clarified. The aim of this study was to elucidate the effect …

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Data from CBX8 Exhibits Oncogenic Activity via AKT/β-Catenin Activation in Hepatocellular Carcinoma

Chris Zhiyi Zhang, Shi‐Lu Chen, Chun‐Hua Wang, Yang-Fan He et autres

Abstract Deregulation of polycomb proteins influences the development and progression of hepatocellular carcinoma. Here we show that chromobox 8 (CBX8) expression is increased in hepatocellular carcinoma and correlates with poor outcome in two independent cohorts containing a total of 879 cases. Ectopic …

Data from CBX8 Exhibits Oncogenic Activity via AKT/β-Catenin Activation in Hepatocellular Carcinoma

Chris Zhiyi Zhang, Shi‐Lu Chen, Chun‐Hua Wang, Yang-Fan He et autres

Abstract Deregulation of polycomb proteins influences the development and progression of hepatocellular carcinoma. Here we show that chromobox 8 (CBX8) expression is increased in hepatocellular carcinoma and correlates with poor outcome in two independent cohorts containing a total of 879 cases. Ectopic …

Targeting the SREBP-1/Hsa-Mir-497/SCAP/FASN Oncometabolic Axis Inhibits the Cancer Stem-like and Chemoresistant Phenotype of Non-Small Cell Lung Carcinoma Cells

Tung-Yu Tiong, Pei-Wei Weng, Chun‐Hua Wang, Syahru Agung Setiawan et autres

BACKGROUND: Lung cancer remains a leading cause of cancer-related death, with an annual global mortality rate of 18.4%. Despite advances in diagnostic and therapeutic technologies, non-small cell lung carcinoma (NSCLC) continues to be characterized by a poor prognosis. This may be associated …

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