Haibin Zhang

Study on the dynamics and heat transfer characteristics of droplet impact on hydrophilic-hydrophobic striped tube

Fuxing Jia, Haibin Zhang, Min Wei, Maocheng Tian

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Epigenetic regulation by DNA methylation, histone modifications and chromatin remodeling complexes in controlling spermatogenesis and their dysfunction with male infertility

Yueling Zhang, Li Du, Fen Jiang, Chunyun Li et autres

As key factors of cellular development, epigenetic regulation can accurately control gene expression through multiple manners, e.g., DNA methylation, histone modification, and chromatin remodeling complexes (CRCs). Epigenetic factors play pivotal roles in various kinds of cell processes, including cell proliferation, differentiation, and …

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The transcriptional regulation of NUPR1 expression by MYC is implicated in the regulation of ferroptosis in human spermatogonial stem cells

Junxiao Yang, Yueling Zhang, Chunyun Li, Wei Chen et autres

Non-obstructive azoospermia (NOA) is a leading cause of male infertility, characterized by impaired spermatogenesis. Recent studies suggest that ferroptosis, an iron-dependent form of cell death, may contribute to testicular dysfunction, however, its role in NOA remains underexplored. In this study, we investigated …

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Silencing of S100A16 in Cervical Cancer Cells Inhibits Cancer Cell Growth by Inducing Autophagy via PI3K/AKT/ mTOR Signaling Pathway

Haibin Zhang, Wenhu Xing, Yufeng Li, Xianyun Xu

The influence of PPARγ mediated MAPK and NF-κB activation in AGEs stimulated apoptosis and autophagy in human chondrocytes

Haibin Zhang, Cheng Chen

Background: Advanced Glycation End Products (AGEs), which accumulate in metabolic syndrome patients and the elderly, are implicated in osteoarthritis (OA) pathogenesis. Peroxisome proliferator-activated receptor-γ (PPARγ), a nuclear receptor, has emerged as a potential therapeutic target for OA. This study investigates the molecular …

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Integrated analysis of ncRNA in hepatocellular carcinoma with CTNNB1 mutations reveals miR-205-5p and miR-3940-3p Axes

Haibin Zhang, Guoqing Zhang, Siyu Lu, Xiaolu Zhang et autres

BACKGROUND: Catenin beta 1 (CTNNB1) mutations are one of the most common mutations involved in hepatocellular carcinoma (HCC) progression. However, the association between CTNNB1 mutations and HCC remains controversial. METHODS: Five tumor samples with wild-type CTNNB1 and three tumor samples with CTNNB1 …

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LncRNA PCED1B-AS1 mediates miR-3681-3p/MAP2K7 axis to promote metastasis, invasion and EMT in gastric cancer

Jia Cao, Yicheng Yang, Bensong Duan, Haibin Zhang et autres

BACKGROUND: LncRNA PCED1B-AS1 is abnormally expressed in multiple cancers and has been confirmed as an oncogene. Our study aimed to investigate the regulatory mechanism of lncRNA PCED1B-AS1 in gastric cancer. METHODS: TCGA database was used to analyze the abnormal expression of lncRNA …

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Introduction of the Chinese expert consensus on postoperative adjuvant therapy for hepatocellular carcinoma (2023 Edition)

Haibin Zhang

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Diagnostic biomarker for type 2 diabetic peripheral neuropathy via comprehensive bioinformatics analysis

Xiaoyu Chen, Qingquan Liu, Niyao Chen, Jiangxin Ma et autres

BACKGROUND: Diabetic peripheral neuropathy (DPN) is a common complication of Type 2 diabetes mellitus (T2DM), which frequently results in disabling neuropathic pain and lower-limb amputation. The identification of noninvasive biomarkers for DPN may help early detection and individualized treatment of DPN. METHODS: …

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THE IMPACT OF COLLECTIVE MEMORY IN THE POST SEVERE INFECTIOUS DISEASE ERA ON COMMUNITY GOVERNANCE

Jiaqi Huang, Haibin Zhang

China has to improve the urban and rural community governance system. This article starts from the combination of “community governance” and “collective memory” in the context of epidemic prevention and control, summarizes the problems existing in community governance during the epidemic through …

Bioinformatic analysis of the expression profile and identification of RhoGDI2 as a biomarker in imatinib-resistant K562 cells

Yang Yulin, Fangmin Zhong, Junyao Jiang, Meiyong Li et autres

Objectives Chronic myeloid leukemia (CML) is an aggressive malignancy originating from hematopoietic stem cells. Imatinib (IM), the first-generation tyrosine kinase inhibitor, has greatly improved theliving quality of CML patients. However, owing to the recurrence and treatment failure coming from tyrosine kinase inhibitor …

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Research Progress in Estrogen-related Receptor Gamma (ERRγ) Agonists and Inverse Agonists

Yong Zheng, Yongli Du, Haibin Zhang, Huiting Lv et autres

Estrogen-related receptor gamma (ERRγ), one of three members of the ERR family, is an inducible transcription factor. ERRγ has dual functions in different tissues. The decreased expression of ERRγ in the brain, stomach, prostate, and fat cells can cause neuropsychological dysfunction, gastric …

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