Lihua Chen

Generation and Characterization of the Human Anti-HTNV Antibody KJJ4

Ziyan Chen, Yanbo Wang, Yongli Hou, Liang Fang et autres

Hantaan virus (HTNV) is the predominant causative agent of hemorrhagic fever with renal syndrome (HFRS) in China, yet no specific antiviral therapy is currently available. Neutralizing antibodies (NAbs) represent a promising strategy, but most existing anti-HTNV NAbs are heterologous and carry immunogenicity …

cn (code pays fourni par la source)

Development and validation of a novel critical risk stratification scale for hemorrhagic fever with renal syndrome patients with Hantaan virus infection

Shijia Wang, Fenglan Wang, Ying Ma, Ran Zhuang et autres

OBJECTIVES: To develop and validate a critical risk prediction model for hemorrhagic fever with renal syndrome caused by Hantaan virus. METHODS: Patients were randomly divided into a training group (n = 344) and a validation group (n = 226). Clinical data were …

cn (code pays fourni par la source)

Methamphetamine and neuroHIV suppress astrocytic potassium channel function in the medial prefrontal cortex via different mechanisms

Lihua Chen, Stefanie L. Cassoday, João I. Mamede, Lena Al‐Harthi et autres

Introduction Methamphetamine (Meth) is a highly addictive psychostimulant that disrupts neuronal function in the medial prefrontal cortex (mPFC), inducing Meth use disorders (MUD). MUD is often complicated by HIV-associated neurocognitive disorders (HAND, a.k.a. neuroAIDS/neuroHIV), and vice versa . MUD and neuroHIV also …

us (code pays fourni par la source)

Rosarin alleviates dry eye disease via suppressing NF-κB signal mediated inflammation and M1 polarization in macrophage

Lihua Chen, Xueping Wei, Zhuo Zhang, Long Shuang Huang et autres

cn (code pays fourni par la source)

100% CO 2 selectivity Fe 2 O 3 / Fe 3 O 4 redox pair of Ba‐hexaferrite for CO 2 capture via relay oxygen donation

Yumei Zhou, Lihua Chen, Hai‐Tao Zhu, Haonan Chen et autres

Abstract Engineering an iron‐based oxygen carrier with high oxygen transport capacity (O t ) surpassing Fe 2 O 3 /Fe 3 O 4 redox pair without decreasing CO 2 selectivity and recyclability remains a substantial obstacle for CO 2 capture via chemical …

tw, cn (code pays fourni par la source)

Development and validation of a novel critical risk stratification scale for HFRS patients with Hantaan virus infection

Shijia Wang, Fenglan Wang, Ying Ma, Ran Zhuang et autres

Background. This study aims to develop and validate a critical risk prediction model for hemorrhagic fever with renal syndrome (HFRS) caused by Hantaan virus across Eurasia. Methods. Clinical data of 570 HFRS patients from Xi’an Eighth Hospital from 2022 to 2023 were …

cn (code pays fourni par la source)

[Construction of NK cell-conditional Cd226 knockout mice and preliminary investigation of their role in ulcerative colitis].

Jianjun Lyu, Zichan Guo, Yazhen Wang, Ziyan Chen et autres

Objective To generate and characterize natural killer cell (NK cell)-conditional Cd226 gene knockout mice using Cre-loxP technology, and to explore the role of CD226 on NK cells in alleviating intestinal inflammation in a murine model of ulcerative colitis (UC). Methods NK cell-conditional …

cn (code pays fourni par la source)

Study on the Path of Integrating Red Culture into the Ideological and Political Education of College Students in the New Era

Linfeng Zhou, Shicheng Hu, Lihua Chen, Zheyu Yang et autres

The purpose of this paper is to discuss the importance of red culture and its integration path in the ideological and political education of college students in the new era. Firstly, the connotation and contemporary value of red culture is analyzed. Secondly, …

cn (code pays fourni par la source)

Hantaan virus infection induces human mucosal-associated invariant T cell pyroptosis through IRE1α pathway

Yusi Zhang, He Liu, Dalu Liu, Huiyuan Zhang et autres

Hantaan virus (HTNV) triggers an epidemic of hemorrhagic fever with renal syndrome (HFRS), which is predominantly prevalent in Asia. Mucosal-associated invariant T (MAIT) cells, categorized as innate-like T lymphocytes, perform crucial functions in the innate host defense mechanism during virus infection. We …

cn (code pays fourni par la source)

Methamphetamine self-administration causes neuronal dysfunction in rat medial prefrontal cortex in a sex-specific and withdrawal time-dependent manner

Lihua Chen, Tabita Kreko‐Pierce, Stefanie L. Cassoday, Lena Al‐Harthi et autres

Methamphetamine (Meth) is one of the most widely used illicit drugs worldwide, exerting potent psychostimulant effects that fuels its highly addictive nature. Chronic Meth use is associated with severe cognitive impairments, particularly in executive functions, decision-making, and working memory, which persist long …

us (code pays fourni par la source)

Expression levels of STAT3, and protein levels of IL‑6 and sPD‑L1 in different pathological characteristics of endometrial adenocarcinomas

Chunxing Ma, Ying He, Jing Wang, Juan Zhang et autres

Endometrial cancer is a common type of cancer in women, with endometrial adenocarcinoma (EA) being the most common type. Monitoring the expression levels of signal transducer and activator of transcription 3 (STAT3), the protein levels of interleukin 6 (IL-6) and soluble programmed …

cn (code pays fourni par la source)

Deformation Control of TC4 Titanium Alloy in Thin-Walled Hyperbolic Structures During Hot Forming Processes

Tao Zhang, Jianchao Xia, Xiuquan Han, Lihua Du et autres

The thin-walled hyperbolic structures made from titanium alloy primarily encompass two typical forms: hyperbolic convex and hyperbolic concave (saddle). This paper addresses the technical challenges associated with the forming processes that frequently result in ripples or wrinkles in these configurations. Specifically, it …

cn (code pays fourni par la source)