Kevin Chen

PROGRESS: Implementation of a novel hybrid decentralized clinical trial to support precision oncology uptake at academic and community oncology practices in North Carolina.

Meghan McGonagle, Stephanie Drotts, Jaime Richardson, Kevin Chen et autres

e23150 Background: Rates of comprehensive molecular profiling (CMP), use of evidence-based genome-informed therapy (GIT), and clinical trial participation remain low in real-world data sets. We designed an interventional clinical trial (PROGRESS) using decentralized methodology to evaluate the impact of a centralized precision …

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Association of immune checkpoint inhibitor administration timing with toxicity and survival in uterine cancer: A real-world analysis.

Meghan McGonagle, Sara Jubas, Kevin Chen, Daniel James Crona et autres

e17640 Background: Evolving data suggest the time of day (ToD) of immune checkpoint inhibitor (ICI) administration may influence toxicity and efficacy, with potentially greater effects in older adults and women. However, data in specific cancer populations, including uterine cancer (UC), remain limited. …

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Abstract 2831: RAS(ON) inhibition in both cancer and immune cells by daraxonrasib drives anti-tumor immunity

Nataliya Tovbis Shifrin, Mariela Moreno Ayala, Cristina Blaj, Kevin Chen et autres

Abstract Daraxonrasib (RMC-6236) is an orally bioavailable, RAS(ON) multi-selective, tri-complex inhibitor of oncogenic mutant and wild-type variants of N, H and KRAS, demonstrating broad activity across RAS-mutant cancers. Preclinical studies have shown that daraxonrasib not only suppresses tumor cell proliferation but also …

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Heterogeneous-Resource-Aware Federated Learning with Intelligent LoRA Allocation and Aggregation

Youye Xie, Yao Lian, Kevin Chen, Abdul Latif et autres

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Heterogeneous-Resource-Aware Federated Learning with Intelligent LoRA Allocation and Aggregation

Youye Xie, Yao Lian, Kevin Chen, Abdul Latif et autres

us (code pays fourni par la source)

Heterogeneous-Resource-Aware Federated Learning with Intelligent LoRA Allocation and Aggregation

Youye Xie, Yao Lian, Kevin Chen, Abdul Latif et autres

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Supplementary Figure S8 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma

Shruthy Suresh, Roy Rabbie, Manik Garg, Dianne Lumaquin et autres

Cholesterol overload activates AP-1 via ERK signaling to mediate invasion upon GRAMD1B loss in melanoma.

Supplementary Figure S6 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma

Shruthy Suresh, Roy Rabbie, Manik Garg, Dianne Lumaquin et autres

Loss of GRAMD1B promotes tumor cell invasion in human melanoma cells

Supplementary Figure S5 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma

Shruthy Suresh, Roy Rabbie, Manik Garg, Dianne Lumaquin et autres

Supp. Fig. S5 shows that GRAMD1B is a metastasis suppressor in human melanoma

Supp Table S2 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma

Shruthy Suresh, Roy Rabbie, Manik Garg, Dianne Lumaquin et autres

Supplementary Table S2. David GO analysis of AVAST-M signature

Supplementary Figure S7 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma

Shruthy Suresh, Roy Rabbie, Manik Garg, Dianne Lumaquin et autres

Loss of GRAMD1B suppresses de novo cholesterol synthesis in melanoma cells.

Supplementary Figure S2 from Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma

Shruthy Suresh, Roy Rabbie, Manik Garg, Dianne Lumaquin et autres

CRISPR Sequencing of MAS2X tumors.