Ke Liu

Shared inflammatory targets of phthalate plasticizers in MODS-related syndromes: An integrative network toxicology study with representative DEHP in vitro validation

Lin Song, Aifeng He, Wei Jiang, Ke Liu et autres

cn (code pays fourni par la source)

Lactate and Lactylation in Immune Cell Function and Autoimmune Diseases: Mechanisms and Therapeutic Potential

Yiying Yang, Ying Zhang, Ke Liu, Huali Zhang et autres

Lactate metabolism plays a crucial role in immune cell function, particularly during inflammation or metabolic stress. Under these conditions, immune cells often undergo a metabolic shift towards glycolysis, resulting in increased lactate production. This reprogramming not only provides energy but also influences …

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New trends and hotspots in sepsis-related protein post-translational modification: a bibliometric and visual analysis

Lin Song, Jian Ma, Wei Jiang, Ke Liu et autres

Background Sepsis is a clinical syndrome characterized by high morbidity and mortality rates, posing a severe threat to human health. Its pathophysiology is complex, involving multiple physiological and pathological processes. Protein post-translational modification (PTM) play a pivotal role in the pathophysiology of …

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Reciprocal METTL3-PAX5 regulation in maintaining B-cell identity and promoting B-cell hyperreactivity in SLE

Yiying Yang, Ying Zhang, Shasha Xie, Ke Liu et autres

OBJECTIVE: METTL3, an m6A methyltransferase, enhances germinal center responses. This study explores its role in lupus B cells and its impact on B-cell activation. METHODS: METTL3 and m6A levels in B cells from systemic lupus erythematosus (SLE) patients and lupus-prone mice were …

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Association of Morphological Changes in the Posterior Horn of the Meniscus of Knee With Anterior Cruciate Ligament Injury: A New Biological Evaluation Index

Yupeng Zhu, Qizheng Wang, Ke Liu, Weili Zhao et autres

Background: The shape and size of the meniscus are closely related to the stability of the knee joint and the anterior cruciate ligament (ACL) injury. Studies have confirmed the correlation between meniscal morphology and isolated ACL injury. Purpose: To investigate meniscal parameters, …

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Identifying Primary Sites of Spinal Metastases: Expert‐Derived Features vs. ResNet50 Model Using Nonenhanced MRI

Ke Liu, Jinlai Ning, Siyuan Qin, Jun Xu et autres

BACKGROUND: The spinal column is a frequent site for metastases, affecting over 30% of solid tumor patients. Identifying the primary tumor is essential for guiding clinical decisions but often requires resource-intensive diagnostics. PURPOSE: To develop and validate artificial intelligence (AI) models using …

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The Dynamic Relationship between Smoking and Secondhand Smoke Risk Factors and Total Cancer Burden: A Global Spatiotemporal Analysis Based on GBD 2021 (2010-2021)

Qizhi Yang, Shengxian Peng, Yue Liu, Lirong Kuang et autres

cn, bd, my (code pays fourni par la source)

Hst-Maflow: Hierarchical Spatio-Temporal Deep Learning Model for Multi-Airport Flow Prediction

Peibo Duan, Siyuan Feng, Ke Liu, Xi Cheng et autres

Post-translational modifications in sepsis-induced organ dysfunction: mechanisms and implications

Lin Song, Wei Jiang, Lin Hua, Jiangquan Yu et autres

As a grave and highly lethal clinical challenge, sepsis, along with its consequent multiorgan dysfunction, affects millions of people worldwide. Sepsis is a complex syndrome caused by a dysregulated host response to infection, leading to fatal organ dysfunction. An increasing body of …

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Deep Learning Based on Knee MRI for Fully Automated Segmentation and Precision Diagnosis of Rheumatoid Arthritis, Gout and PVNS

Qizheng Wang, Meiyi Yao, Yandong Liu, Xinhang Song et autres

Segmentation of synovial-related structures in MRI images can help assess synovitis-effusion, infrapatellar fat pad (IPFP) changes, and response to treatment, which is important for the clinical diagnosis of knee disease. However, segmenting images manually, which depends on the skill and experience of …

Modifiable lifestyle factors, genetic susceptibility, and incident ankylosing spondylitis

Ke Liu, Hao Lin, Jiacheng Ying, Peiyang Luo et autres

Abstract Background: Whether the lifestyle is associated with the risk of ankylosing spondylitis (AS) in the presence of different genetic risk levels remains unknown. We aimed to evaluate modifiable lifestyle-genetic susceptibility interaction with the risk of AS. Methods: This study included 382,035 …

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Association Between Hyperuricemia and Ultrasound‐Detected Hand Synovitis

Ting Jiang, Qianlin Weng, Yuqing Zhang, Weiya Zhang et autres

OBJECTIVE: Although hand synovitis is prevalent in the older population, the etiology remains unclear. Hyperuricemia, a modifiable metabolic disorder, may serve as an underlying mechanism of hand synovitis, but little is known about their relationship. We assessed the association between hyperuricemia and …

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