Qianqian Zhang

Exploration of the Framework and Standard System of Forestry Data Governance Based on Shaanxi Provincial Ecological Cloud Sensing System

Liu Y, Hongyu Cheng, Qianqian Zhang, Xinshuang Wang et autres

Against the backdrop of the Digital China strategy, forestry data governance underpins ecological governance modernization. Taking Shaanxi Provincial Ecological Cloud Sensing System as the object, this study leverages its advantages of dual middle platforms and the unified map integrating forests, grasslands, wetlands …

cn (code pays fourni par la source)

Financing Constraints and Sticky Behavior of R&D Expenses: The Moderating Role of Green Innovation Strategy

Qianqian Zhang, Fei Zhai

This study examines how financial constraints affect the sticky behavior of Research and Development (R&D) expenditures, with particular emphasis on the moderating role of green innovation. While maintaining R&D investment during sales declines is critical for sustainable innovation, the convex nature of …

cn, kr (code pays fourni par la source)

Synthesis of a novel specific nectin-4 tumor-targeted peptide optical molecular probe and its preliminary study in lung cancer

Ting Jiang, Ke Dong, Jianfei Fu, Yong Zheng et autres

Nectin-4/PVRL-4 is overexpressed in tumors, driving proliferation and invasion. It's a key target for solid tumor therapy. Current tumor imaging methods are inadequate. Studying nectin-4 in lung cancer helps identify diagnostic biomarkers and develop radionuclide probes, intraoperative visualization,and new chemotherapies. High nectin-4 …

cn (code pays fourni par la source)

The relationship between nutrition, hemoglobin, and frailty in elderly patients with Myelodysplastic Syndromes: A mediation effect analysis

Jinying Zhao, Qianqian Zhang, Wenjun Xie, Erlie Jiang

Abstract Objective The purpose of this study is to identify the hematological and non-hematological factors influencing frailty, to investigate the relationship between nutrition, hemoglobin, and frailty, and to clarify the mediating effect of hemoglobin. This research aims to provide a mechanistic basis …

cn (code pays fourni par la source)

DEAD-box helicase DDX24 is essential for endothelial mitochondrial function to maintain the blood-brain barrier

Shuai Li, Yuxuan Liu, Yingying Dong, Yujiao Gong et autres

The blood-brain barrier (BBB) is essential for brain function, yet its underlying regulatory mechanisms remain elusive. Here, we identify DEAD-box RNA helicase 24 (DDX24) as a regulator of the BBB. Endothelial-specific Ddx24 knockout ( Ddx24 ECKO ) mice exhibit deficits in learning …

cn (code pays fourni par la source)

Inferring causal trajectories from spatial transcriptomics using CASCAT

Yingying Yu, Wan Nie, Qianqian Zhang, Shuai Cheng Li

Spatial trajectory inference models cell differentiation and state dynamics within tissues by integrating spatial information. Existing spatial trajectory inference methods depend on similarity-based cell graphs constructed from spatial proximity, with less attention to the Markovian property in cell state transitions. In this …

hk, cn, us (code pays fourni par la source)

Analysis and verification of potential ferroptosis-related diagnostic markers in the early stage of metabolic dysfunction-associated steatohepatitis

Qianqian Zhang, Aigang Ren, Haiyan Zhang

cn (code pays fourni par la source)

Renewal Design of an Urban Heritage Park: The Case of King Yu’s Terrace Park

Qianqian Zhang, Zhi He, Kaiwen Sun

With the increasing awareness of heritage city protection around the world, relevant laws and regulations are constantly improving, and the methods and approaches for protection are gradually enriching [1]. Heritage protection work has made significant progress. In recent years, heritage parks have …

A retrospective real-world single-arm study evaluating the efficacy and safety of neoadjuvant chemotherapy in patients with selected limited-stage small-cell lung cancer

Wengang Zhang, Yujie Li, Jing Nie, Wencheng Zhao et autres

Background: With the advancement of surgical techniques and the introduction of neoadjuvant therapies, the risk of recurrence or distant metastases has been significantly decreased for non-small-cell lung cancer (non-SCLC) after surgery. In recent years, the application of these advanced techniques and therapies …

cn (code pays fourni par la source)

Haplotype‐Resolved Genotyping and Association Analysis of 1,020 β‐Thalassemia Patients by Targeted Long‐Read Sequencing (Adv. Sci. 9/2025)

Yuhua Ye, Chao Niu, Aiping Mao, Lang Qin et autres

Targeted Long-Read Sequencing of 1,020 β-Thalassemia Patients In article number 2410992, Yuhua Ye, Xiangmin Xu, and co-workers demonstrate the key haplotypes associated with ameliorated clinical symptoms of β-thalassemia by targeted long-read sequencing in a cohort of 1,020 β-thalassemia patients. These findings not …

Rapid detection of genetic modifiers of β-thalassemia based on MALDI-TOF MS

Li‐Min Huang, Qianqian Zhang, Yuhua Ye, Yong Long et autres

Fetal hemoglobin (HbF) levels are influenced by various genetic modifiers, which have clinically beneficial effects on both β-thalassemia and sickle cell disease. HbF-associated genetic variants are distributed throughout the genome, and current detection methods are often costly, time-consuming, and require multiple tests. …

cn (code pays fourni par la source)

Haplotype‐Resolved Genotyping and Association Analysis of 1,020 β‐Thalassemia Patients by Targeted Long‐Read Sequencing

Yuhua Ye, Chao Niu, Aiping Mao, Lang Qin et autres

Despite the well-documented mutation spectra of β-thalassemia, the genetic variants and haplotypes of globin gene clusters modulating its clinical heterogeneity remain incompletely illustrated. Here, a targeted long-read sequencing (T-LRS) is demonstrated to capture 20 genes/loci in 1,020 β-thalassemia patients. This panel permits …

cn (code pays fourni par la source)