Yuan Wang

Molecular Regulation of Primordial Germ Cell Specification and Implications for In Vitro Gametogenesis

Maddison Marshall, Eryl Bevan, Yuan Wang

Primordial germ cells (PGCs) are the embryonic precursors of gametes, essential for transmitting genetic and epigenetic information across generations. However, PGC specification occurs within a narrow developmental window and involves only a small number of cells, making it difficult to study in …

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Identification of GADD45B, HMGB3, LMNB2, and MFAP5 as lactylation-related prognostic markers for survival prediction in esophageal cancer

Shuo Li, Shaomin Quan, Jun Ma, Yunbo Bai et autres

Background: Lactylation, a protein modification driven by lactate produced during glycolysis, has been implicated in tumorigenesis and immune suppression, and may influence patient prognosis. This study aimed to identify lactylation-related prognostic genes and explore their potential functional relevance. Methods: The Cancer Genome …

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Abstract 3305: Biochemical and cellular evaluation of HUNK inhibition by an FDA approved drug as potential therapeutic strategy for HER2+ breast cancer

Safnas Farwin AbdulSalam, Mia M. Eason, Shuguang Liang, Alison Goupil et autres

Abstract Kinase inhibitors have been on spotlight for cancer drug discovery ever since the approval of Imatinib and recently the 100th small molecule kinase inhibitor was approved by the FDA showing the potential of kinase inhibitors for cancer therapeutics and beyond. HER2 …

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Topological derivative-driven high-resolution topology optimization of arbitrary structures with smooth boundaries

Zhikai Tang, Ping Zhang, G. J. Chen, Genlai Zhang et autres

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Trimethyltin exposure induced oxidative damage and immune dysfunction in sea urchin Strongylocentyotus intermedius

Jing Chen, Yuying Liu, Yuan Wang

RNA-Binding Protein NF90 Mediates Polycomb-Independent Transactivation by EZH2 to Promote Cancer Growth

Yuan Wang, Peng Liu, Xiaodong Lü, Hongshun Shi et autres

Increasing evidence suggests critical roles of the polycomb-independent transactivation function of EZH2 in promoting some cancers, such as prostate cancer (PCa), yet the underlying mechanism remains poorly understood. Here, we identify the RNA-binding protein NF90 as a key mediator of this activity. …

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Corrigendum to “Addressing the role of 11β-hydroxysteroid dehydrogenase type 1 in the development of polycystic ovary syndrome and the putative therapeutic effects of its selective inhibition in a preclinical model” [Metab Clin Exp 119 (2021) 154749 1–14 [METABOLISM-D-20-01502R3]]

Xinyu Li, Shuanggang Hu, Qinling Zhu, Guangxin Yao et autres

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First- and Second-Order Raman Spectroscopy of Quasi-One-Dimensional ZrS 3 Single Crystal

Lei Cui, Yi Cheng, Yuan Wang, Yuxiang Yang et autres

We performed angle-resolved Raman scattering studies on quasi-one-dimensional ZrS 3, by rotating the crystals from 0° to 360° to tune the angle between the crystal axis and the polarization direction of the incident light, the significant angular dependences of the Raman peak …

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YWHAH‑driven autophagy via MAPK/ERK signaling enhances CRC cell migration and invasion

Qiang Li, Yuan Wang, Yuan Zhao, Peng Zhai et autres

experiments showed that YWHAH overexpression promoted proliferation, and epithelial‑mesenchymal transition of CRC cells, while inhibiting apoptosis. Conversely, YWHAH knockdown exerted opposite effects. Autophagy assays demonstrated that YWHAH knockdown enhanced autophagy by upregulating autophagy related 7 and LC3II/I and downregulating P62, whereas overexpression …

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HIV infection and risk of COPD: a two-sample Mendelian randomization study

Yuanjie Li, Yuan Wang, Zhixin Qiu

Background: The causal relationship between HIV infection and COPD remains unclear, with some studies suggesting an elevated risk in HIV-infected individuals, while others show no correlation, particularly in female patients. Objectives: This study assessed the causal relationship between HIV infection and COPD …

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The interventional effect of astragaloside IV on rodent models of myocardial fibrosis: a systematic review and meta-analysis

Haozhe Li, Yunhang Chu, Yue Wang, Yuan Wang

Objective: This study was conducted to evaluate the interventional effects of astragaloside in a rodent model of myocardial fibrosis (MF). Methods: Data from studies related to the intervention of astragaloside IV (AS-IV) in rodent models with myocardial fibrosis were systematically retrieved and …

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GASZ directly recruits MILI to the intermitochondrial cement for piRNA biogenesis and male germ cell development

Junru Miao, Zhaoran Zhang, Duong Nguyen, Hanben Wang et autres

Repressing transposable elements via piRNAs represents a critical defense mechanism for germ cells to maintain genomic integrity. The primary piRNA biogenesis largely occurs at intermitochondrial cement (IMC), which is characterized by uniquely clustered mitochondria and ribonucleoproteins as "cementing material." RNA-binding proteins at …

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