Hongtao Li

Resolution of Severe Jaundice Following Hepatic Artery Infusion of Bevacizumab and 5-Fluorouracil With Oral Regorafenib in Metastatic Colorectal Cancer：A Case Report

Xiuli Zhang, Yan Zhou, Wenxi Yu, Chen Liang Zhou et autres

Objective:Unusual or unexpected effect of treatment Background:Hepatic artery infusion (HAI) chemotherapy has been established as an indispensable treatment for hepatic metastatic colorectal cancer (CRLM), particularly in patients with multiple lesions. Case Report:We report the case of a patient diagnosed with liver metastasis …

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CLTR-09 SYNERGISTIC EFFECT BETWEEN ACT001 AND WBRT/ICI IN NSCLC PATIENTS WITH BRAIN METASTASIS: THE INTERIM ANALYSIS OF A PHASE 2, MULTI-CENTER AND DOUBLE-BLIND RCT STUDY

Linlin Wang, Hui Wang, Xinhong Liu, Ruitai Fan et autres

Abstract Background Based on efficacy data from early phase study, the synergistic effect of ACT001 with WBRT/ICI was evaluated in expanded cohorts of NSCLC subjects. Methods Pretreated NSCLC with 4 or more metastatic brain lesions, most negative for driver mutations, were randomized …

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Pyrotinib Plus Trastuzumab and Docetaxel with Different Antidiarrheal Strategies in Patients with HER2-Positive Recurrent or Metastatic Breast Cancer (PHAENNA): A Multicenter, Phase 1 Trial

Wei Ren, Xiuping Lai, Guiying Bai, Yanqiong Liu et autres

Purpose: The outcomes of different antidiarrheal strategies in HER2-positive breast cancer patients treated with pyrotinib plus trastuzumab and docetaxel are unknown. Materials and Methods: 97 eligible patients received pyrotinib once daily from Cycle 1 Day 7 onwards, combined with intravenous trastuzumab and …

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Fovinaciclib for First-Line Therapy of Advanced Breast Cancer

Peng Yuan, Liu Y, Wei Li, Huiping Li et autres

Importance: Approximately 70% of patients with breast cancer (BC) have hormone receptor-positive, human epidermal growth factor receptor 2 (ERBB2; formerly HER2)-negative disease. Objective: To evaluate the efficacy and safety of fovinaciclib plus an aromatase inhibitor as first-line treatment for hormone receptor-positive, ERBB2-negative …

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Acupuncture for Early Parkinson’s Motor Symptoms: A Multicenter Randomized Controlled Trial Protocol

J ian-xing Zhang, Yici Xie, Weixin Huang, Junshang Wu et autres

Background: Pharmacological treatment of motor disorders in early Parkinson (PD) has reached a bottleneck, and acupuncture as an important component of non-pharmacological therapy has demonstrated therapeutic potential. However, current evidence is limited in both quantity and quality, highlighting the need for further …

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First-in-human dose escalation trial of an engineered salmonella delivering L-methioninase in advanced bone and soft tissue sarcomas.

Hongtao Li, Xiaopeng Yu, Allan Zijian Zhao, Fanghong Li et autres

11530 Background: Advanced bone and soft-tissue sarcomas have limited treatment options. Tumor-selective methionine dependency is a known metabolic vulnerability. SGN1 is designed to deplete methionine locally within tumors via intratumoral colonization of an attenuated Salmonella vector expressing L-methioninase. Preclinical studies have demonstrated …

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Fovinaciclib versus placebo combined with fulvestrant for advanced breast cancer after endocrine therapy: A randomized, double-blind phase 3 trial.

Xichun Hu, Liu Y, Biyun Wang, Zhongsheng Tong et autres

1101 Background: Approximately 70% breast cancer (BC) patients have hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative disease. Fovinaciclib is a novel, potent, oral selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor. A multicenter, randomized, double-blind, placebo-controlled phase 3 …

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Unlocking pan-cancer detection via phenyl-β-D-glucuronide-induced breath analysis

Cuili Xue, Chenghan Yi, Lei Zhang, Siyi Xiang et autres

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Resolution of Severe Jaundice Following Hepatic Artery Infusion of Bevacizumab and 5-Fluorouracil in Metastatic Colorectal Cancer: A Case Report

X. L. Zhang, Yan Zhou, Wenxi Yu, Chenliang Zhou et autres

Resolution of Severe Jaundice Following Hepatic Artery Infusion of Bevacizumab and 5-Fluorouracil in Metastatic Colorectal Cancer: A Case ReportXiuli Zhang1* , Yan Zhou1* , Wenxi Yu1, Chen liang Zhou1, Guangzhi Wang1, Guowei Qian1, Yujing Huang1, Yang

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Global burden of thyroid cancer attributable to metabolic risk factors in women of reproductive age (20–49 years): a GBD 2021 cross-national analysis with projections to 2050

Hongtao Li, Yuan Liu, Zhibin Hu, Eddie Lin

BACKGROUND: Thyroid cancer incidence has risen steadily worldwide, making it one of the most common endocrine malignancies. Women of reproductive age experience rates roughly three times higher than men, a disparity increasingly attributed not only to hormonal factors but also to metabolic …

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Supplementary Table S1 from First-in-Maintenance Therapy for Localized High-Grade Osteosarcoma: An Open-Label Phase I/II Trial of the Anti–PD-L1 Antibody ZKAB001

Yan Zhou, Qingcheng Yang, Yang Dong, Tong Ji et autres

Summary of Exposure to ZKAB001, All Treated Patient Population

Supplementary Figure S1 from First-in-Maintenance Therapy for Localized High-Grade Osteosarcoma: An Open-Label Phase I/II Trial of the Anti–PD-L1 Antibody ZKAB001

Yan Zhou, Qingcheng Yang, Yang Dong, Tong Ji et autres

Kaplan-Meier curves for Event-free Survival (EFS) in each dose group