Ye Li

Decoding Obesity Through the Lens of Adipose Tissue Inflammatory Regulation: A Comparative Study of Obesity Subtypes

Yinuo Chen, Yuchen Zhang, Yuang Song, Haonan Xing et autres

Obesity is increasingly recognized as a heterogeneous condition rather than a single disease entity. Although body mass index remains widely used in clinical practice, it does not adequately reflect differences in fat distribution, metabolic status, inflammatory activity, or body composition. As a …

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Hyperglycemia-driven pH-gated multi-enzyme cascade nanoparticle microneedles for programmed therapy of diabetic infected wounds

Jia Wang, Huiwen Zhang, Ye Li, Shitong Zhang et autres

Chronic diabetic wounds heal poorly due to persistent hyperglycemia, recurrent infection, and dysregulated inflammation, while their complex microenvironment poses major therapeutic challenges. Yet, therapeutic strategies that actively modulate the wound microenvironment for microenvironment-responsive treatment remain largely underexplored. Here, we engineered a biomimetic …

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Porous Architecture and Pressure-Induced Latent Injury: New Insights Into Large-Volume Fat Grafting

Y Zhang, Bin Li, Jiancong Liang, Yucheng Luo et autres

BACKGROUND: Large-volume autologous fat grafting for aesthetic augmentation is often complicated by cysts and fibrosis, suggesting that its survival mechanisms differ from those of small-volume grafts. OBJECTIVES: To investigate the survival biology of large-volume fat grafts and evaluate the effects of mechanical …

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Corynoline and Extracellular Vesicles Co-Loaded Scaffold Accelerates Vascularized Bone Regeneration with Photothermal Stimulation

Rou Li, Chaochen Wang, Yong Xie, Weitong Gao et autres

Bone defect repair remains a major clinical challenge, and effective alternatives to autologous bone grafting are urgently needed due to limitations such as donor site scarcity, immune complications, and high long-term resorption rates. In this study, we developed a near-infrared (NIR)-responsive composite …

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Expression of Concern: EBV encoded miRNA BART8-3p promotes radioresistance in nasopharyngeal carcinoma by regulating ATM/ATR signaling pathway

Xiaohan Zhou, Jialing Zheng, Ying Tang, Yanling Lin et autres

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Associations of urinary and follicular fluid phthalate exposure with salpingitis in women seeking fertility treatment

Qingqing Hou, Hongmei Liao, Zhimo Zhang, Jiaying Yuan et autres

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Exosomal Lnc-DLK1-35 reprograms microglia into a pro-tumorigenic phenotype via a non-canonical cytokine signature to promote glioblastoma progression and chemoresistance

Di Li, Ye Li, Zhuo Wang, Xuan Zheng et autres

INTRODUCTION: Temozolomide (TMZ) resistance in glioblastoma (GBM) involves dynamic crosstalk of cancer cells with tumor-associated microglia, but the role of exosomal long non-coding RNAs (lncRNAs) remains poorly defined. MATERIAL AND METHODS: We isolated exosomes from TMZ-sensitive (U251) and TMZ-resistant (U251TR) GBM cells. …

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Case Report: A case of Culler-Jones syndrome caused by GLI2 gene mutation

Xiaomei Xie, Youfen Wei, Ye Li, Junyan Wang et autres

Culler-Jones syndrome (CJS) (OMIM: 615849) is a rare genetic condition characterized by considerable phenotypic variability. This case reports a 5-day-old male neonate who presented with postaxial polydactyly, growth restriction, and recurrent epileptic seizures. A thorough clinical workup, including laboratory investigations, imaging, and …

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The past, present, and future of adipose tissue browning and aging: A review combined with bibliometrics and bioinformatics of 2527 documents published over the past four decades

Yucheng Luo, Minxi Zeng, Bin Li, Ye Li et autres

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Novel senescence inducer ICA-11c, a derivative of icaritin, YAP-dependently suppresses hepatocellular carcinoma cells

Hongfei Chen, Shuai Shen, Shuang-li Wang, Ye Li et autres

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Reflective Blankets vs Electric Warming in Preventing Hypothermia During Liposuction: A Randomized Controlled Trial

Yuchen Zhang, Jiancong Liang, Haonan Xing, Yucheng Luo et autres

BACKGROUND: Perioperative hypothermia is common during liposuction and can lead to delayed recovery, shivering, and patient discomfort. Although electric warming (EW) systems are effective, their use may be limited in certain settings. OBJECTIVES: The authors of this study aim to evaluate the …

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miR- 34c- 5p targets ROCK1 expression to inhibit kidney injury in diabetic nephropathy rats through MAPK/ERK signaling pathway

Ye Li, H. Liu, Pan Li, Huiling Duo et autres

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