Li Wang

The Application Value of Chromosome Microarray Analysis in Prenatal Diagnosis of Clinically Relevant Copy Number Variations in Fetuses

Huifang Liu, Wei Wang, Zhaoling Zhu, Bo Zhang et autres

Objective: Exploring the clinical application value of chromosome microarray analysis (CMA) technology in detecting clinically relevant copy number variations (CNVs) in fetuses and evaluating its efficacy in prenatal diagnosis. Methods: A retrospective analysis was conducted on 2860 pregnant women undergoing prenatal diagnosis …

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Risk prediction models for postoperative intra-abdominal infection in patients with digestive system tumors: a systematic review

Yu Wang, Li Wang, Yunhong Du, Jianwei Li et autres

Background: Postoperative intra-abdominal infection (IAI) is a severe complication in digestive system tumor patients, increasing hospital stays, costs, and mortality. Accurate prediction enables early intervention and better prognosis. However, existing prediction models lack comprehensive evaluation due to diverse study designs, data sources, …

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A Rare Case of Long-Term Survival in Stage IIIB Lung Adenocarcinoma: an 9-Year Follow-Up

Jianing Chen, Li Liu, Qi Wang, Yan Wu et autres

We report a rare case of long-term survival in a 59-year-old male patient diagnosed with stage IIIB lung adenocarcinoma. Despite disease progression following initial chemotherapy, the patient achieved prolonged survival through a combination of chemotherapy and radiotherapy. This case highlights the potential …

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Noncoding RNAs as regulators of FOSL1 in cancer

Xiaochang Wang, Li Wang, Shoushi Wang, Jinjie Zhang et autres

The AP-1 transcription factor FOSL1, also known as Fra-1, is a crucial oncoprotein that plays an important role in human tumor progression and metastasis and has thus emerged as a promising therapeutic target. FOSL1 regulates the expression of a large protein-coding gene …

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Novel diagnostic and therapeutic strategies based on PANoptosis for hepatocellular carcinoma

Jie Xiang, Yukai Li, Shengmin Mei, Zhenyu Ou et autres

Hepatocellular carcinoma (HCC), a highly aggressive liver cancer, poses a large medical care burden worldwide. The prognosis of patients with HCC is poor, owing to recurrence and metastasis after common treatment methods. Therefore, identifying new targets to eliminate HCC cells is critical …

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Circulating tumor DNA for MRD detection in colorectal cancer: recent advances and clinical implications

De-Ning Ma, Xinyi Gao, Li Wang, Huan Yin et autres

Circulating tumor DNA (ctDNA)-based molecular residual disease (MRD) provides a powerful approach to predict recurrence in colorectal cancer (CRC) and potentially improve survival outcomes for individuals diagnosed with CRC. Currently, there are two primary technical approaches for the detection of MRD using …

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Tebotelimab plus niraparib in previously treated locally advanced or metastatic solid tumors: A phase 1b dose escalation and expansion study

Miao‐Zhen Qiu, Hongming Pan, Ka On Lam, Jufeng Wang et autres

BACKGROUND: This open-label, single-arm, phase 1b dose escalation and expansion study (ClinicalTrials.gov identifier NCT04178460) explored the safety, tolerability, and antitumor activity of tebotelimab, a programmed cell death protein 1 × lymphocyte-activation gene 3 bispecific monoclonal antibody, in combination with niraparib, a poly(adenosine …

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First evidence of olaparib maintenance therapy in patients with newly diagnosed homologous recombination deficient positive/BRCA wild-type ovarian cancer: real-world multicenter study

Jing Li, Youguo Chen, Mian He, Xiaoxiang Chen et autres

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Potential tumor-specific antigens and immune landscapes identification for mRNA vaccine in thyroid cancer

Xiaoning Wang, Guixin Wang, Qiaoqiao Xu, Yingxi Li et autres

Background: Tumor mRNA vaccines have been identified as a promising technology for cancer therapy in multiple cancer types, while their efficacy in thyroid cancer (THCA) is unclear. Immunotyping is strongly associated with the immune microenvironment and immune status in cancer, thus it …

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Single-cell RNA Sequencing Demonstrates the Heterogeneity of Different Molecular Subtypes in Gastric Cancer

Ming Ren, Hongyan Ma, Lijia Guo, Yuqing Liu et autres

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Pulmonary function tests for identifying pathological invasive stage I lung adenocarcinoma: A multiple-center retrospective cohort study

Yü Liu, Xueyun Tan, Guanzhou Ma, Dong Yang Zhao et autres

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Clinical Significance and Molecular Annotation for PD-L1 Negative Advanced Non-Small Cell Lung Cancer with Sensitivity to Responsive to Dual PD-1/CTLA-4 Blockade

Li Wang, Li Liu, Jing Zhao, Xin Yu et autres

Background: Immunotherapy has become the standard treatment for driving gene-negative advanced non-small cell lung cancer (NSCLC). However, compared to PD-L1-positive patients, the efficacy of Anti-PD-(L)1 monotherapy is suboptimal in PD-L1-negative advanced NSCLC. In this study, we aim to analyze the optimal immunotherapy …

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