Jingyu Zhang

Hierarchical Point Cloud Analysis for 3D Defect Detection of Annular Welds

Jingyu Zhang, Yong Da Yan, Shuaiyi Wu, Chuangyu Duan

Annular fillet welds on guide rods lie in stress concentration zones and are susceptible to fatigue failure under dynamic suspension loads, necessitating accurate quality inspection. However, their complex three-dimensional topography makes it difficult for conventional methods to balance detection accuracy and efficiency. …

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Hong Cui et autres

Psoriasis is a systemic immune‑mediated skin disease, typically considered to be incurable. Identification of meaningful biomarkers has been a notable challenge in psoriasis prevention and management. The present study aimed to determine the signature genes driving psoriasis and their underlying mechanism. Microarray …

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The gut‑skin axis: Emerging insights in understanding and treating skin diseases through gut microbiome modulation (Review)

Yu Zhao, Chenchen Yu, Jingyu Zhang, Qinghua Yao et autres

Emerging evidence indicates a significant association between the composition and functionality of the gut microbiome and various skin disorders, including psoriasis, atopic dermatitis, acne and several dermatological conditions. The gut‑skin axis theory describes a complex bidirectional communication network between the gut and …

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[Identification and expression analysis of AP2/ERF family members in Lonicera macranthoides].

Mei-Ling Qu, Juan Zeng, Jiawei He, Jingyu Zhang et autres

The AP2/ERF transcription factor family is a class of transcription factors widely present in plants, playing a crucial role in regulating flowering, flower development, flower opening, and flower senescence. Based on transcriptome data from flower, leaf, and stem samples of two Lonicera …

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Weld seam location with adaptive fracture repair on minor-caliber pipe

Jingyu Zhang, Li Guo, Heming Zhao, Fan Zhang

High-precision weld positioning is crucial for enhancing welding quality and structural reliability. Current algorithms are challenged by uneven laser reflectivity, complex surface curvature, and noise interference. To overcome these obstacles, we propose a multi-stage adaptive weld centering framework integrating line laser scanning, …

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Weld Seam Location with Adaptive Fracture Repair on Minor- Caliber Pipe

Yong Yan, Jingyu Zhang, Li Guo, Heming Zhao et autres

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High-Throughput Computer Screen Aids Discovery of Methotrexate as miR-20b Inhibitor to Suppress Nonsmall Cell Lung Cancer Progression

Xiaorui Shi, Chong Hu, Bin Guo, Jingyu Zhang et autres

MicroRNAs (miRNAs) play a significant role in tumor progression, and regulating miRNA expression with small molecules may offer a new approach to cancer therapy. Among them, miRNA-20b has been found to be dysregulated in several cancers, including nonsmall cell lung cancer (NSCLC). …

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Discovery of a Novel Non-invasive AR PROTAC Degrader for the Topical Treatment of Androgenetic Alopecia

Xinfei Mao, Weitong Hu, Mingfei Wu, Yuyuan Jin et autres

Elevated expression levels and enhanced activity of androgen receptor (AR) proteins are key factors in the development of androgenetic alopecia (AGA). AR proteolysis-targeting chimera (PROTAC) degraders have shown therapeutic potential, but their poor skin permeability requires invasive delivery methods. In this study, …

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Discovery of a Highly Potent and Selective BRD9 PROTAC Degrader Based on E3 Binder Investigation for the Treatment of Hematological Tumors

Haiting Duan, Jingyu Zhang, Renzhao Gui, Yang Lu et autres

BRD9 is a pivotal epigenetic factor involved in cancers and inflammatory diseases. Still, the limited selectivity and poor phenotypic activity of targeted agents make it an atypically undruggable target. PROTAC offers an alternative strategy for overcoming the issue. In this study, we …

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Construction of a Zygosaccharomyces rouxii strain overexpressing the QOR gene for increased HDMF production

Yanhong Wang, Xinhui Wang, Peng Jiang, Lingyan Dai et autres

Abstract 4‐Hydroxy‐2,5‐dimethyl‐3(2H)‐furanone (HDMF) is a flavor compound widely found in natural products and is used in food as a flavor‐enhancing agent. Quinone oxidoreductase (QOR) was verified as a key enzyme to synthesize HDMF in strawberry, while its impact on HDMF production by …

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[Research progress on Rhododendron molle in treatment of rheumatoid arthritis].

Wen-ya Mei, Xiang-Dan Liu, Zhi‐Hui Wang, Junbao Yu et autres

Rheumatoid arthritis(RA), as a chronic autoimmune disease, has a high incidence and disability rate, causing significant suffering to patients. Due to its complex pathogenesis, it has not been fully elucidated to date, and its treatment remains a challenging problem in the medical …

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Structure-based identification of new orally bioavailable BRD9-PROTACs for treating acute myelocytic leukemia

Jingyu Zhang, Haiting Duan, Renzhao Gui, Mingfei Wu et autres

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