Mei Li

Comparison of Silevimig, a Novel Bispecific Anti-Rabies Monoclonal Antibody, with Human Rabies Immunoglobulin for Post-Exposure Prophylaxis: A Phase III, Randomized, Double-Blind, Non-Inferiority Trial

Xiuqing Wang, Jing He, Yongxian Zha, Ya Jiang et autres

This phase III randomized, double-blind, non-inferiority trial evaluated Silevimig, a bispecific anti-rabies monoclonal antibody targeting antigenic sites I and III, as a substitute for human rabies immunoglobulin (HRIG) in post-exposure prophylaxis. Adults (>18 years) with suspected WHO category III rabies exposure were …

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Soil moisture shifts under warming are associated with divergent topsoil nitrogen responses in permafrost-affected ecosystems

Yuanrui Peng, Tao Wang, Wolfgang Wanek, Yuanhe Yang et autres

Understanding how soil nitrogen (N) responds to climate warming is critical for predicting permafrost carbon-climate feedbacks, yet long-term N responses and their underlying mechanisms remain elusive. Here we show that divergent topsoil N responses to warming are associated with warming-induced shifts in …

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Integration of real-time patient vital signs into an electronic transport checklist to improve clinical decision-making and checklist responsiveness

Mei Li, Qichen He, Xuexin Shen

This study aimed to evaluate whether integrating real-time vital signs into an electronic intrahospital transport checklist improves abnormal vital sign recognition time, clinical intervention response time, checklist completion efficiency, and transport-related safety outcomes. This prospective, before-and-after (quasi-experimental) observational study was conducted at …

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Overcoming ADC resistance in advanced colorectal cancer by dual targeting of TROP2 and PERK to suppress Wnt/β-catenin signaling

Jie Liu, Mei Li, Jianming Huang, Yujie Xia et autres

Targeted therapy for advanced colorectal cancer (CRC) remains a significant unmet clinical need. Here, we investigate the mechanism of the anti-TROP2 antibody-drug conjugate IMMU132, delivering SN-38 to induce TOP1-mediated DNA damage and cytotoxicity. We further discover that it concurrently suppresses the PERK-eIF2α-ATF4 …

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A TROP2-targeting ADC synergizes with oxidative phosphorylation inhibitor to enhance apoptosis in ESCC by suppressing the PI3K-AKT-mTOR signaling pathway

Xinxin Liu, Jie Liu, Mei Li, Youban Xiao et autres

Currently, there are no effective targeted therapies for advanced esophageal squamous cell carcinoma (ESCC). Trophoblast cell surface antigen-2 (TROP2) are considered robust therapeutic targets which leverages antibody-drug conjugates (ADCs) to control solid tumors. Mitochondrial oxidative phosphorylation (OXPHOS) influences the growth of cancer …

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MRD-guided azacitidine maintenance improves outcomes in molecularly persistent pediatric core-binding factor AML: A retrospective cohort study

Chunping Wu, Yiqiao Chen, Chunxia Cai, Mei Li et autres

Abstract Background: Relapse remains a major challenge in pediatric acute myeloid leukemia (AML), particularly in non-transplant-eligible patients. Although hypomethylating agents, such as azacitidine, are hypothesized to target residual disease, their efficacy and safety in de novo pediatric AML maintenance therapy require validation. …

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Preoperative prediction of lymph node metastasis risk in papillary thyroid carcinoma based on multiple model comparisons

Yuanyuan Zhou, Yu-zhi Zhang, Juan Li, Zhiqiang Li et autres

The clinical necessity of lymph node dissection in papillary thyroid carcinoma (PTC) surgery remains contentious. This study compared four logistic regression (LR) models (with distinct feature selection strategies) and four machine learning (ML) models to preoperatively predict lymph node metastasis (LNM) risk …

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From 3D culture to clinical decision-making: Systematic innovations in breast cancer organoids

Mingyu Hu, Chenxin Zhou, Mei Li, Jiyuan Zhao

Breast cancer is a malignant tumour with high heterogeneity. Traditional research models rely mainly on 2D cell culture and patient-derived tumour xenografts (PDXs). However, these models have limited use in clinical trials because of their shortcomings in mimicking the tumour microenvironment and …

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Deciphering the immunomodulatory cross-talk: Bacterial extracellular vesicles in gut homeostasis

Hui Yi, Mei Li, Le Xu, Huajie Mao

Within mammalian gastrointestinal ecosystems, trillions of microorganisms generate sophisticated ecological networks through bacterial extracellular vesicles (bEVs). Emerging evidence positions these bEVs as pivotal mediators in gut homeostasis maintenance and host-microbiota crosstalk, capable of transporting bioactive cargo including virulence determinants, genetic transfer components, …

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Alpha-ketoglutarate restores oral epithelial homeostasis via FOXM1-mediated cell cycle regulation

Yuan Wang, Qi Yin, Shuqin Cao, Yuyu Li et autres

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Author response for "Microwave-Triggered Organic Sensitizer for Synergistic Dynamic/Thermal Therapy of Osteosarcoma"

Man Shu, Xiao Chu, Qiao Zhou, Guoqing Zhong et autres

COL4A2 drives ECM remodeling and stiffness increasing to promote breast cancer metastasis via YAP signaling pathway in dECM induced models

Jing Peng, Weilai Zhu, Chi Zhang, Jie Ye et autres

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