Lei Si

Cost-effectiveness of zanubrutinib versus ibrutinib as first-line treatment for patients with Waldenström macroglobulinemia in China

Weiqi Chen, Yongyi Wu, Qiyun Zhu, Bin Jiang et autres

BACKGROUND: Zanubrutinib has demonstrated superior efficacy and safety over ibrutinib for Waldenström macroglobulinemia (WM) in the phase 3 ASPEN trial, but its cost-effectiveness in China remains unknown. This study evaluated the cost-effectiveness of zanubrutinib versus ibrutinib as first-line treatment for WM from …

cn, us, au (code pays fourni par la source)

Projection of Stroke Incidence and Costs in China: 2022 to 2050

Yutong Jiang, Lizheng Xu, Xia Wang, Meiqiyang Xue et autres

BACKGROUND: Stroke imposes a substantial and growing health and economic burden in China, yet forward-looking estimates of stroke-related costs remain scarce. METHODS: Annual age- and sex-specific incidence rates of ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage were projected from 2022 to 2050 …

cn, au (code pays fourni par la source)

Whole-genome resequencing reveals population genetic structure and selective sweeps in Bombus waltoni

Rui Zhang, Chengbo Liang, Wenrui Jiao, Lei Si et autres

BACKGROUND: Bombus waltoni is a typical alpine bumblebee species and an important indicator species of the Qinghai-Tibetan Plateau. However, whole-genome studies of bumblebees from this region remain limited. In this study, we investigated the genetic diversity, population structure, and adaptive genomic variation …

cn (code pays fourni par la source)

Cost-effectiveness of multitarget stool DNA testing for colorectal cancer screening in Chinese primary healthcare settings: a modelling study

Hang Su, Jingyi Li, Xinyi Zhang, Zhihui Xiu et autres

Aim To evaluate the cost-effectiveness of a one-time mt-sDNA-based colorectal cancer screening program compared with no screening, using real-world data from a government-led population-based screening program in Harbin Municipality of China.Methods This modelling study was based on a real-world mt-sDNA CRC screening …

cn, au, tw (code pays fourni par la source)

A prognostic model incorporating MCP-1 and IL-8 for early risk stratification in acute ischemic stroke patients receiving intravenous thrombolysis: a retrospective development with temporal validation

Huiyuan Zhang, Lei Si, Yamin Song, Huiqian Guo et autres

Objective To investigate the expression characteristics of monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in patients with acute ischemic stroke (AIS) who received intravenous thrombolysis and their relationship with clinical prognosis. Methods This retrospective study included 300 patients with AIS who received …

cn, gb (code pays fourni par la source)

Comparative review of selected health technology assessment agencies: Features and insights for health technology assessment development and improvement

Zonglin Dai, Effie Ka Yue Cheung, Ting Wang, David Makram Bishai et autres

Health technology assessment (HTA) is increasingly used to guide coverage and pricing decisions, but many countries lack formal HTA agencies or rely on fragmented processes. This study aims to compare institutional and procedural features of selected HTA agencies and to derive policy …

us, cn, hk, gb, au, mo, ch (code pays fourni par la source)

Temporal Trends and Cross‐Country Inequalities in the Burden of Osteoarthritis, 1990–2021: Findings From the Global Burden of Disease Study 2021

Haowei Chen, Lei Si, Lei Zhang, David John Hunter et autres

AIM: This study aimed to assess the long-term trends in cross-country inequalities related to the burden of osteoarthritis from 1990 to 2021. METHODS: Data on osteoarthritis incidence, prevalence, years lived with disability, and sociodemographic index (SDI) were extracted from the Global Burden …

cn, au (code pays fourni par la source)

Ambient PM2.5, residential greenspace, and household healthcare expenditure in Shandong, China

Siyuan Wang, Zhiwei Xu, Gian Luca Di Tanna, Raksha Pandya‐Wood et autres

au, ch, cn (code pays fourni par la source)

Individual and household determinants of overweight and obesity among children and adolescents in China

Meiqiyang Xue, Yutong Jiang, M Chen, Lei Si

Background: Overweight and obesity among children and adolescents are a global concern. Research on the combined influence of individual and household factors on overweight and obesity among children and adolescents across China remains relatively limited, especially regarding parental social capital. This study …

cn, au (code pays fourni par la source)

Productivity-adjusted life year loss among the late middle-aged adults in China

Yawen Jiang, Bingxin Hu, Huiqiao Gu, Wenjie Hu et autres

Productivity-adjusted life years (PALYs) measure the impact of health conditions on an individual’s ability to contribute productively to the economy. However, they have not been evaluated for the Chinese population. We aim to estimate PALYs for the Chinese population aged 50 to …

cn, au (code pays fourni par la source)

Cost-effectiveness of the simplified multicomponent primary care management of cardiovascular risk in Tibet, China: a within-trial and modeled economic evaluation

Lidan Wang, Maoyi Tian, Bolu Yang, Nicholas Peoples et autres

cn, us, au (code pays fourni par la source)

Understanding women’s preferences for long-acting reversible contraceptives in Gondar, Ethiopia: a discrete choice experiment

Ousman Ambaw, Amare Minyhun, Tsegaw Amare Baykeda, Haimanot Wubale Tewabe et autres

BACKGROUND: In Ethiopia, limited use of long-acting reversible contraceptives (LARCs) contributes to unintended pregnancies, unsafe abortions, and preventable maternal deaths. Despite their proven effectiveness, LARCs remain underutilized. Evidence on women's preferences and willingness to pay (WTP) is scarce. This study examined women's …

Éthiopie, au (code pays fourni par la source)