Xuan Wang

Genomics meets metabolomics: decoding Arnebia tschimganica and the shikonin biosynthesis pathway

Xuan Wang, Changyi Wang, Minkai Yang, Xiaohui Lai et autres

Abstract Arnebia tschimganica is a vulnerable species within the Boraginaceae (Boraginales), which has long been taxonomically debated due to inconsistent molecular and morphological characteristics. Shikonin and its derivatives, which are found in the roots of Boraginaceae species, possess significant pharmacological and industrial …

us, cn, cz (code pays fourni par la source)

Systematic characterization of the R2R3-MYB family in Lithospermum erythrorhizon and regulatory mechanisms of LeMYB1 in shikonin biosynthesis

Xuan Wang, Yalan Si, Wencai Jie, Xiao Zhang et autres

Lithospermum erythrorhizon is a medicinal plant valued for its ability to produce shikonin and its derivatives, a compound with important pharmacological properties. While R2R3-MYB transcription factors are known regulators of plant metabolism, no genome-wide analysis had been conducted in L. erythrorhizon. In …

cn (code pays fourni par la source)

Blocking PCSK9 suppresses hepatocellular carcinoma immune escape by decreasing FLI1-mediated SPP1 and PD-L1 expression

Changpeng� Hu, Ming Qin, Wenjing Lai, Huyue Zhou et autres

Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a newly identified immunosuppressive regulator, but its mechanism of suppressing antitumor immunity remains ambiguous. This study aims to uncover the underlying mechanism by which PCSK9 promotes hepatocellular carcinoma (HCC) immune escape and to explore …

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GLP-1 receptor agonists synergistic effects of metabolic reprogramming and cardioprotection

Xuan Wang, Mengmeng Qi, Lili Yang, Libo Yang et autres

Diabetes mellitus, a condition that significantly elevates the incidence and mortality risks associated with cardiovascular diseases, exacerbates the disease burden in China. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have garnered considerable attention, as they not only regulate blood glucose but also play a …

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Trichosanthin Fused to Thermo-pH-Sensitive Polypeptides for Synergistic Cancer Immunotherapy

Fan Zhang, Like Gong, Yinghao Zheng, Meiling Zhou et autres

Immunogenic cell death (ICD) induced in cancer chemotherapy, radiotherapy, and photodynamic therapy can facilitate the maturation of dendritic cells (DCs) and the activation, proliferation, and tumor infiltration of cytotoxic T lymphocytes, which may synergize with immune checkpoint blockade (ICB) therapy to improve …

cn (code pays fourni par la source)

GPNMB Expression Identifies FLCN-Associated Eosinophilic Renal Tumors With Heterogeneous Clinicopathologic Spectrum and Gene Expression Profiles

Qiuyuan Xia, Xiaotong Wang, Yao Shi Fu, Ming Zhao et autres

FLCN -associated eosinophilic renal tumors mainly refer to hybrid oncocytic/chromophobe tumors (HOCT) and other oncocytic tumors related to Birt-Hogg-Dubé (BHD) syndrome, which can sometimes occur sporadically. Accurate diagnosis of FLCN -associated tumors is challenging due to their morphologic heterogeneity and the lack …

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Thermo‐pH‐Sensitive Polypeptides Boost Protein Drug's Tumor Permeation and Pharmacology

Like Gong, Yuan Qi, Fan Zhang, Yuanzi Sun et autres

Abstract Proteins are typically subject to poor stability, short half‐life, and poor cell and tissue permeability, which restrict their wide applications as drugs for disease treatment. Current protein modification techniques mostly focus on improving the stability and half‐life of proteins, but hardly …

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SMARCA4/BRG1 deficiency induces a targetable dependence on oxidative phosphorylation in clear cell renal cell carcinoma

Ru Fang, Xiaotong Wang, Rui Wu, Rui Pan et autres

The tumor suppressor gene SMARCA4, a critical component of the SWI/SNF chromatin remodeling complex, is frequently inactivated in various cancers, including clear cell renal cell carcinoma (ccRCC). Despite its significance, the role of SMARCA4 in ccRCC development and its potential therapeutic vulnerabilities …

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Combining same-target drugs exhibits additive efficacy with minimal toxicity

Shaoqing Cai, Yi Wang, Feng Xu, Qian Zhao et autres

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Mechanical support for the treatment of fulminant myocarditis combined with cardiac arrest and MODS in children: A case report and review

Xuan Wang, Guangmei Zou

A 13 years and 1 month old child was admitted to the hospital with fulminant myocarditis. After admission, the child's condition deteriorated rapidly, with a rapid drop in blood pressure, alternating malignant arrhythmias, such as ventricular tachycardia and ventricular fibrillation, and then …

cn (code pays fourni par la source)

Dynamic changes of SCGN expression imply different phases of clear cell renal cell carcinoma progression

Tuanjie Guo, Xuan Wang, Tao Wang, Yang Liu et autres

The secretagogin (SCGN) was originally identified as a secreted calcium-binding protein present in the cytoplasm. Recent studies have found that SCGN has a close relationship with cancer. However, its role in the occurrence, progression, and prognosis of clear cell renal cell carcinoma …

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IBI310 (anti-CTLA-4 antibody) monotherapy or in combination with sintilimab in advanced melanoma or urothelial carcinoma

Chuanliang Cui, Juan Li, Yue Yang, Lu Si et autres

IBI310 is a recombinant fully human IgG1 antibody against cytotoxic T lymphocyte antigen 4. This study was conducted to evaluate IBI310 monotherapy or combination therapy with sintilimab in the patients with advanced melanoma or urothelial carcinoma (UC). Patients in phase 1a received …

cn, Éthiopie, us (code pays fourni par la source)