Fei Li

Peptide Angio‐3 Attenuates Pulmonary Fibrosis Via Modulation of the Coagulation Factor Xa—Protease‐Activated Receptor‐1 Signaling Axis

Dan Wang, Fei Li, Huiling Chen, Bochuan Deng et autres

Pulmonary fibrosis (PF) is a chronic, progressive, and often fatal interstitial lung disease characterized by interstitial remodeling, fibroblastic foci formation, and excessive extracellular matrix (ECM) deposition. Current therapeutic options remain limited and are associated with unfavorable prognoses. Growing evidence indicates that dysregulated …

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Correction to: Prediction of double expression status of primary CNS lymphoma using multiparametric MRI radiomics combined with habitat radiomics: a double-center study

Jianxin Zhao, Lijun Liang, Jixian Li, Qi Li et autres

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Prediction of double expression status of primary CNS lymphoma using multiparametric MRI radiomics combined with habitat radiomics: a double-center study

Jianxin Zhao, Lijun Liang, Jixian Li, Qi Li et autres

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Prediction of Double Expression Status of Primary CNS Lymphoma Using Multiparametric MRI Radiomics Combined with Habitat Radiomics: A Double-center Study

Jianxin Zhao, Lijun Liang, Jixian Li, Qi Li et autres

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Substrate recognition and allosteric regulation of synaptic vesicle glutamate transporter VGLUT2

Fei Li, Jacob Eriksen, Juan A. Osés-Prieto, Yessica K. Gomez et autres

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Genistein resists castration-resistant prostate cancer by inhibiting the androgen receptor pathway

Xiaoping Yu, Lujie Zheng, Jiali Yan, Yan Luo et autres

Prostate cancer is a prevalent malignancy, often diagnosed at advanced stages and associated with poor prognosis. Genistein, a soybean isoflavone, has demonstrated antitumor effects against castration-resistant prostate cancer in vivo. Our results indicate that genistein effectively downregulates the expression of key enzymes …

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Gut microbiota depletion and FXR inhibition exacerbates zonal hepatotoxicity of sunitinib

Qi Zhao, Ying‐Mei Lu, Jingyi Duan, Dan Du et autres

supplementation may be used to improve sunitinib-induced hepatotoxicity.

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NLRP10 maintains epidermal homeostasis by promoting keratinocyte survival and P63-dependent differentiation and barrier function

Yeonhee Cho, Zhongzheng Cao, Xin Luo, Jennifer J. Tian et autres

Atopic dermatitis (AD) is a common chronic inflammatory skin disorder characterized by disrupted epidermal barrier function and aberrant immune responses. Despite recent developments in new therapeutics for AD, there is still a large unmet medical need for disease management due to the …

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Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome

Boyang Zhao, Zhongzheng Cao, Yi Zheng, Phuong Trang Nguyen et autres

Heparan sulfate (HS) is degraded in lysosome by a series of glycosidases. Before the glycosidases can act, the terminal glucosamine of HS must be acetylated by the integral lysosomal membrane enzyme heparan-α-glucosaminide N-acetyltransferase (HGSNAT). Mutations of HGSNAT cause HS accumulation and consequently …

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Improved efficacy and safety of zanubrutinib versus ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia (R/R CLL) in China: a subgroup of ALPINE

Keshu Zhou, Tingyu Wang, Ling Pan, Wei Xu et autres

Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) has different epidemiology in Chinese vs. Western patients, but there are few studies of CLL/SLL in large populations of Chinese patients. ALPINE is a global phase 3 trial investigating Bruton tyrosine kinase inhibitors zanubrutinib vs. ibrutinib …

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Abstract 6348: Unveiling diverse trimeric forms of STEAP1 in human prostate cancer cells: Exploring STEAP1-STEAP2 interdependence for expression and plasma membrane localization

Cong Li, Lingming Liang, Joonhee Park, Olga Pryshchep et autres

Abstract Six-Transmembrane Epithelial Antigen of the Prostate 1 (STEAP1) is an emerging therapeutic target that is a member of the STEAP1-4 family of metalloreductases. We recently reported the preclinical characterization of xaluritamig (AMG 509), a STEAP1 XmAb® 2+1 T-cell engager molecule that …

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Supplementary Table S1 from AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer

Olivier Nolan-Stevaux, Cong Li, Lingming Liang, Jinghui Zhan et autres

Binding properties of AMG 509 and monovalent anti-STEAP1 XmAb molecules.