Yanling Jin

Venetoclax plus azacitidine, low‐dose cytarabine, aclarubicin, and G‐CSF (VA‐CAG regimen) for newly diagnosed young patients with acute myeloid leukemia: A prospective, multicenter, single‐arm Phase II clinical trial

Xiaoping Li, Qiurong Zhang, Xiaoyan Li, Lin Liu et autres

Abstract We conducted a prospective, multicenter, Phase II study to evaluate the safety and efficacy of venetoclax/azacitidine/low‐dose cytarabine/aclarubicin/granulocyte colony‐stimulating factor (G‐CSF) (VA‐CAG) in young patients with newly diagnosed acute myeloid leukemia (ND‐AML). The VA‐CAG regimen included venetoclax (100 mg/day, Days 1–2; 200 …

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PI3Kα Inhibitor and Degrader Inavolisib Can Co-opt FGFR2 to Enhance Responses in Patients with PIK3CA -Mutated Solid Tumors and in Preclinical Models

Dejan Juric, Kyung Soon Song, Radia Marie Johnson, Melissa Accordino et autres

PURPOSE: PIK3CA mutations frequently drive solid tumors, particularly hormone receptor-positive breast cancer. Inavolisib, an ATP-competitive p110α inhibitor, also promotes the degradation of mutated p110α. PI3K inhibitors have generally shown modest single-agent activity and have safety concerns. PATIENTS AND METHODS: A first-in-human phase …

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Primary Squamous Cell Carcinoma of the Thyroid Has a Molecular Genetic Profile Distinct From That of Anaplastic Thyroid Carcinoma

Meihua Ye, Zhenying Guo, Jingjing Xu, Yanling Jin et autres

BACKGROUND: Primary squamous cell carcinoma (SCC) of the thyroid and anaplastic thyroid carcinoma (ATC) show significant clinical and histologic overlap. Their biological behaviors are so similar that the fifth WHO updates SCC as a morphologic pattern of ATC rather than a separate …

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Venetoclax Plus Azacitidine, Low Dose Cytarabine, Aclarubicin and G-CSF (VA-CAG Regimen) for Newly Diagnosed Young Patients with Acute Myeloid Leukemia: A Prospective, Multicenter, Single-Arm Phase 2 Clinical Trial

Xiaoping Li, Xiaoyan Li, Yanling Jin, Zucong Chen et autres

Background: Venetoclax, in combination with hypomethylating agents or low-dose cytarabine, is approved for newly diagnosed acute myeloid leukemia (AML) patients who are over 75 years of age or not eligible for intensive chemotherapy, while the efficacy of venetoclax-based regimens in young fit …

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Contributors

Hamisu Abdullahi, Sharafudeen Dahiru Abubakar, Mansur Aliyu, Abubakar Umar Anka et autres

Nigéria, jp, ir, us, fr, qa, it, cn, br (code pays fourni par la source)

How can visual communications aid in renewable energy development?

Na Li, Yanling Jin, Ying Li, Xinyuan Ma

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Association between Galectin-13 Expression and Eosinophilic Airway Inflammation in Chronic Obstructive Pulmonary Disease

Lingling Yi, Yuchen Feng, Dian Chen, Yanling Jin et autres

Chronic obstructive pulmonary disease (COPD) and asthma are chronic inflammatory diseases of the airways. Galectin-13 has recently been forwarded as a biomarker for airway eosinophilic inflammation in asthma. However, the association between galectin-13 and COPD remains unknown. To examine the changes in …

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Comprehensive Evaluation of China’s Input–Output Sector Status Based on the Entropy Weight-Social Network Analysis Method

Yanling Jin, Yi Xu, Rui Li, Changping Zhao et autres

In order to understand the source of China’s global influence, the key sectors and important connections in China’s economic and trade networks should be identified. Based on China’s 2002–2018 input–output data, this study uses the entropy weight method to determine weights, and …

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A Network Pharmacology-based Mechanism of the Traditional Chinese Medicine Formula Li Kun Zhi Ji acting on Colon Cancer

Guoyan Liu, Yanling Liu, Linshan Duan, Long Li et autres

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基于NOD2/RIP2/NF-κB信号通路研究柚皮素对新生大鼠缺血缺氧性脑损伤的保护作用

冯祝婷, Feng Zhu-ting, 冯占辉, Feng Zhan-hui et autres

目的探讨柚皮素对新生大鼠缺血缺氧性脑损伤的保护作用及其机制。 方法96只7日龄新生SD大鼠，随机分为4组，假手术组(Sham)、缺血缺氧性脑损伤组(HIBD)、柚皮素低剂量组(50 mg·kg-1)、柚皮素高剂量组(100 mg·kg-1)。术后48 h对各组新生大鼠进行神经功能缺陷评分，HE染色观察各组新生大鼠脑组织病理学改变，干湿重法检测各组新生大鼠脑含水量，免疫印迹法测定缺血缺氧侧脑组织NOD2、RIP2、NF-κB蛋白的表达，酶联免疫吸附法检测TNF-α、IL-1β的水平。 结果与模型组比较，柚皮素低、高剂量组神经行为学指标评分下降，病理学损伤减轻，新生大鼠脑含水量明显减少(P 结论柚皮素对新生大鼠缺血缺氧性脑损伤有保护作用，其机制可能与柚皮素下调NOD2、RIP2、NF-κB蛋白的表达，并减少TNF-α、IL-1β的分泌有关。

CpG-ODN对新生大鼠缺血/缺氧性脑损伤的保护作用研究

黄莹, Huang Ying, 叶兰, Lan Ye et autres

目的 探讨Toll样受体9(Toll-like receptor 9，TLR9) 激动剂——含CpG基序的寡核苷酸(CpG-ODN)对新生大鼠缺血/缺氧性脑损伤的保护作用机制。 方法 50只健康7日龄新生Wistar大鼠，♀♂不限，随机分为5组，假手术组、缺血/缺氧性脑损伤(HIBD)组、CpG-ODN低剂量组(0.35 mL·kg-1)、CpG-ODN中剂量组(1.40 mL·kg-1)、CpG-ODN高剂量组(5.60 mL·kg-1)。术后48 h对大鼠神经功能进行评分，光学显微镜下观察脑组织病理学改变。免疫印迹法检测缺血/缺氧侧脑组织中磷酸化p38 MAPK、TLR9表达，酶联免疫吸附法检测TNF-α的表达。 结果 CpG-ODN低、中剂量组较模型组神经行为学评分降低，病理学损伤减轻，而高剂量组较模型组神经行为学评分升高(P < 0.05)，病理学损伤加重；Western blot分析结果表明，缺血/缺氧侧脑组织中磷酸p38 MAPK、TLR9蛋白表达逐渐上调，TNF-α在脑组织中含量逐渐升高(P < 0.05)。 结论 TLR9激动剂CpG-ODN低、中剂量可改善新生大鼠脑缺血/缺氧损伤神经行为学评分及神经系统功能，减轻新生大鼠缺血/缺氧性脑损伤，其机制可能是通过适度激活p38 MAPK信号通路，并分泌适量TNF-α发挥作用。

Ion-Velocity Map Imaging Study of Photodissociation Dynamics of Acetaldehyde

Zhiguo Zhang, Zhichao Chen, ZHANG Cui-Mei, Yanling Jin et autres

The photodissociation dynamics of acetaldehyde in the radical channel CH3+HCO has been reinvestigated using time-sliced velocity map imaging technique in the photolysis wavelength range of 275–321 nm. The CH3 fragments have been probed via (2+1) resonance-enhanced multiphoton ionization. Images are measured for …

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