Successful Gene Editing of Apolipoprotein E4 to E3 in Brain of Alzheimer Model Mice After a Single IV Dose of Synthetic Exosome-Delivered CRISPR
Bruce Teter, Jesus J. Campagna, Chunni Zhu, Grace E. McCauley et autres
Abstract Background The gene for apolipoprotein E4 (ApoE4 E4) confers an increased risk for development and lowers the age of onset of Alzheimer’s disease (AD), and is a highly suitable target for CRISPR-based editing because ApoE4 differs from ApoE3 by a single …
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bioRxiv (Cold Spring Harbor Laboratory)