Accès ouvert
2025
article
OpenAlex
Noah Brown, Aleksander Łuniewski, Xuanxuan Yu, Michelle D. Warthan et autres
Changes in the copy number of large genomic regions, termed copy number variations (CNVs), contribute to important phenotypes. CNVs are readily identified using conventional approaches when present in a large fraction of the cell population. However, CNVs in only a few genomes …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Shiwei Liu, Julia Zulawinska, Emily R. Ebel, Aleksander Łuniewski et autres
BACKGROUND: Increases in the copy number of large genomic regions, termed amplifications, are an important adaptive strategy for many organisms. Numerous amplifications across the AT-rich Plasmodium falciparum genome contribute directly to drug resistance or impact the fitness of this protozoan parasite. During …
us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Noah Brown, Aleksander Łuniewski, Xuanxuan Yu, Michelle D. Warthan et autres
ABSTRACT Changes in the copy number of large genomic regions, termed copy number variations (CNVs), contribute to important phenotypes. CNVs are readily identified using conventional approaches when present in a large fraction of the cell population. However, CNVs in only a few …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Noah Brown, Clemente da Silva, Caroline Webb, Daniela Matias et autres
ABSTRACT While the Plasmodium falciparum malaria parasite continues to cause severe disease globally, Mozambique is disproportionally represented in malaria case totals. Acquisition of copy number variations (CNVs) in the parasite genome contributes to antimalarial drug resistance through overexpression of drug targets. Of …
us, Mozambique
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Accès ouvert
2023
preprint
OpenAlex
Shiwei Liu, Emily R. Ebel, Aleksander Łuniewski, Julia Zulawinska et autres
Abstract Increases in the copy number of large genomic regions, termed genome amplification, are an important adaptive strategy for malaria parasites. Numerous amplifications across the Plasmodium falciparum genome contribute directly to drug resistance or impact the fitness of this protozoan parasite. During …
us
(code pays fourni par la source)