Andrew McHorse

Structure and Stability of Phospholipid-Based Microbubbles Studied Using a Spin Probe.

Samuel Weaver, Paul A. Dayton, Lauren E. Jarocha, Andrew McHorse et autres

Steady-state electron paramagnetic resonance (EPR) spectroscopy is used to investigate the structure and stability of surfactant microbubbles made from distearoylphosphatidylcholine (DSPC) phospholipids and a polymeric stabilizer. The spin probe doxyl-5-stearic acid (5DSA) was incorporated into the phospholipid monolayer at an overall concentration …

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Using hyperpolarised xenon-129 magnetic resonance imaging to investigate longitudinal effects of long COVID on pulmonary function

Ivina Mali, Mitchell Harrison, Bradie Frizzell, Mario Castro et autres

Extract Post-acute COVID-19 syndrome, or long COVID, is a condition where individuals continue to experience or develop symptoms >4–12 weeks following the initial SARS-CoV-2 infection, with symptoms often persisting for months. Some common symptoms include fatigue, cough, shortness of breath (dyspnoea), and …

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Structure and Stability of Phospholipid-Based Microbubbles Studied Using a Spin Probe

Lauren E. Jarocha, Jason E. Streeter, Samuel Weaver, Andrew McHorse et autres

High Resolution Image Download MS PowerPoint Slide Steady-state electron paramagnetic resonance (EPR) spectroscopy is used to investigate the structure and stability of surfactant microbubbles made from distearoylphosphatidylcholine (DSPC) phospholipids and a polymeric stabilizer. The spin probe doxyl-5-stearic acid (5DSA) was incorporated into …

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Respiration Monitoring with Remote Pneumatic Dose Administration for 129Xe MRI

Drew Clements, Suphachart Leewiwatwong, Anna Costelle, Andrew McHorse et autres

Motivation: Repeatability of hyperpolarized 129Xe MRI measurements is dependent on lung inflation volume. Currently, there is no standard for respiration coaching or dose delivery. Goal(s): Determine the variables that affect lung inflation during 129Xe MRI to standardize best practices for coaching and …

Optimized methods for robust calculation of chemical shifts in hyperpolarized 129Xe MR spectroscopy

Seth Lee, Andrew McHorse, Anna Costelle, Bastiaan Driehuys

Motivation: Hyperpolarized 129Xe RBC chemical shift is an increasingly important biomarker for lung disease, but the robustness of its calculation has not been investigated. Goal(s): The aim of this study is to identify a more accurate and optimal method of calculating RBC …

129Xe Gas Exchange MRI in Obesity-associated Asthma: Clinical Correlates and Regional Patterns

David G. Mummy, Jennifer L. Ingram, Andrew McHorse, Gangaram Singh et autres

Abstract Rationale. The complex interplay of factors contributing to the pathobiology of obesity-associated asthma is poorly understood. Advancing understanding of the unique disease mechanisms driving gas exchange abnormalities in asthma with comorbid obesity may improve patient management in this difficult to treat …

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Lung Volume Correction Increases Repeatability of 129Xe Gas Exchange MRI in IPF

Andrew McHorse, Aparna C. Swaminathan, Robert M. Tighe, Bastiaan Driehuys et autres

Abstract RATIONALE:A range of hyperpolarized 129Xe gas exchange MRI markers have been proposed to assess disease progression and therapy response in diverse cardiopulmonary conditions, including COPD and types of ILD. However, variation in the breath hold maneuver is known to affect these …

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Multi-site Analysis of Functional Gas Exchange Measures on 129Xe MRI Among Healthy Volunteers

Andrew McHorse, H. Qin, Peter J. Niedbalski, Adam Schmidt et autres

Abstract RATIONALE: Hyperpolarized 129Xe gas exchange MRI has shown promise as a diagnostic and prognostic tool for diverse cardiopulmonary conditions, including asthma, COPD, and interstitial lung diseases. The increasing clinical use of 129Xe MRI requires a thorough characterization of the normal variation …

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Increased BMI Is Associated With Elevated Membrane Uptake on 129 Xe Gas Exchange MRI in Healthy Subjects

Andrew McHorse, Shuang‐Nan Zhang, Aparna C. Swaminathan, Loretta G. Que et autres

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