Meg K. Tully

Quantification of cure for pharmacodynamic models of antimalarial drugs: Deterministic versus stochastic approaches

Meg K. Tully, Robert J. Commons, J. A. Simpson, David J. Price

In silico pharmacokinetic-pharmacodynamic (PK-PD) models are used to inform dose optimisation in antimalarial drug development. Here the PK-PD models capture the change in parasite count over time because of exposure to antimalarial drug(s). For current deterministic PD models, simulated parasite numbers decline …

au, gb (code pays fourni par la source)

The associations between gas cooking stoves, indoor NO2 concentrations, and adverse sleep outcomes in a pediatric sample

Jing Wang, Seyni Gueye‐Ndiaye, Xiaoyu Li, Sanjana Bhaskar et autres

STUDY OBJECTIVES: To investigate whether gas cooking stove exposure and elevated indoor nitrogen dioxide (NO2) concentration were associated with adverse sleep outcomes in a pediatric sample. METHODS: Children from urban neighborhoods in Boston, Massachusetts underwent in-home sleep assessments. Indoor NO2 concentrations were …

us, cn (code pays fourni par la source)

Quantification of cure for pharmacodynamic models of antimalarial drugs: deterministic versus stochastic approaches

Meg K. Tully, Ruiz Francisco J., J. A. Simpson

In silico pharmacokinetic-pharmacodynamic (PK-PD) models are used to inform dose optimisation in antimalarial drug development. Here the PK-PD models capture the change in parasite count over time due to exposure to antimalarial drug(s). For current deterministic PD models, simulated parasite numbers decline …

au (code pays fourni par la source)

Evaluation of a Bayesian hierarchical pharmacokinetic–pharmacodynamic model for predicting parasitological outcomes in Phase 2 studies of new antimalarial drugs

Meg K. Tully, S Dini, Jennifer A. Flegg, James McCarthy et autres

The rise of multidrug-resistant malaria requires accelerated development of novel antimalarial drugs. Pharmacokinetic-pharmacodynamic (PK-PD) models relate blood antimalarial drug concentrations with the parasite-time profile to inform dosing regimens. We performed a simulation study to assess the utility of a Bayesian hierarchical mechanistic …

au, gb (code pays fourni par la source)

Associations between indoor fine particulate matter (PM2.5) and sleep-disordered breathing in an urban sample of school-aged children

Jing Wang, Seyni Gueye‐Ndiaye, Cecilia Castro‐Diehl, Sanjana Bhaskar et autres

us (code pays fourni par la source)

Evaluation of a Bayesian hierarchical pharmacokinetic-pharmacodynamic model for predicting parasitological outcomes in Phase 2 studies of new antimalarial drugs

Meg K. Tully, S Dini, Jennifer A. Flegg, James McCarthy et autres

Abstract The rise of multidrug resistant malaria requires accelerated development of novel antimalarial drugs. Pharmacokinetic-pharmacodynamic (PK-PD) models relate blood antimalarial drug concentrations with the parasite-time profile to inform dosing regiments. We performed a simulation study to assess the utility of a Bayesian …

au (code pays fourni par la source)