Accès ouvert
2024
article
OpenAlex
Alton S. Barbehenn, Lei Shi, Junzhe Shao, Rebecca A. Hoh et autres
Abstract Despite antiretroviral therapy (ART), HIV persists in latently-infected cells (the HIV reservoir) which decay slowly over time. Here, leveraging >500 longitudinal samples from 67 people living with HIV (PLWH) treated during acute infection, we developed a mathematical model to predict reservoir …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Gregory D. Whitehill, Jaimy P. Joy, Francesco Elia Marino, Ryan Adam Krause et autres
BACKGROUNDEarly antiretroviral therapy initiation (ARTi) in HIV-1 restricts reservoir size and diversity while preserving immune function, potentially improving opportunities for immunotherapeutic cure strategies. For antibody-based cure approaches, the development of autologous neutralizing antibodies (anAbs) after acute/early ARTi is relevant but is poorly …
us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Alton S. Barbehenn, Lei Shi, Junzhe Shao, Rebecca A. Hoh et autres
ABSTRACT Despite antiretroviral therapy (ART), HIV persists in latently-infected cells (“the reservoir”) which decay slowly over time. Here, leveraging >500 longitudinal samples from 67 people with HIV (PWH) treated during acute infection, we developed a novel mathematical model to predict reservoir decay …
us
(code pays fourni par la source)