Madeleine Ndahayo

Historical redlining and oral squamous cell carcinoma staging at diagnosis.

Pei‐Lun Kuo, Lisa Mary Schumaker, Olive Beyer, Raquel Rowell et autres

e22598 Background: Previous research has shown that residents in historically redlined zones, areas defined from the discriminatory housing policy in 1935-1940, are more prone to being diagnosed with later-stage cancer for breast cancer, cervical cancer, lung cancer, colorectal cancer, and prostate cancer. …

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Abstract 5969: Splicing variability and oncogenic isoforms: Transforming our understanding of HNSCC biology

Daria A. Gaykalova, Madeleine Ndahayo, Ishita Gupta

Abstract Head and neck squamous cell carcinoma (HNSCC) remains a cancer type with limited effective targeted therapies, currently restricted to anti-EGFR (Cetuximab) and anti-PD1 agents (Nivolumab and Pembrolizumab), and only one clinically established biomarker (HPV or its surrogate p16, applicable to ∼30% …

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The impact of genomic ancestry on tumor genomics in head and neck squamous cell carcinoma

Madeleine Ndahayo, Anirudh Saxena, Hannah Thomas, Kathryn Hughes Barry et autres

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Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena et autres

PIK3R1, a regulatory subunit of class IA phosphoinositide-3-kinase (PI3K), undergoes alternative splicing to generate multiple isoforms, primarily p85α and p55α. The canonical isoform p85α associates with the catalytic subunit p110α to form the active PI3K complex, which regulates key cellular functions such …

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Abstract A045: The functional role of UBASH3B in HPV-head and neck squamous cell carcinoma and implications on racial disparities

Madeleine Ndahayo, Cameron Westlake, Erin Allor, Ishita Gupta et autres

Abstract Head and Neck Squamous Cell Carcinoma (HNSCC) is a group of malignancies that develop from the epithelial lining of the oral cavity, pharynx, and larynx. Notably, HNSCC is one of the top cancers with pronounced racial disparities in clinical outcomes, where …

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Investigating the role of UBASH3B in cancer: structural relevance, physiological functions, and therapeutic possibilities

Cameron Westlake, Madeleine Ndahayo, Ishita Gupta, Daria A. Gaykalova

Head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer globally and presents a persistent clinical challenge due to the limited availability of effective targeted therapeutics. Recent studies have identified the ubiquitin-associated and SH3 domain-containing B (UBASH3B), a tyrosine …

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Abstract 5698: Opposing roles of HOXC6 isoforms in promoting head and neck squamous cell carcinoma

Ishita Gupta, Subhendu Roy Choudhury, Avinash Saxena, Madeleine Ndahayo et autres

Abstract HOXC6, a member of the homeobox (HOX) family is a homeoprotein transcription factor regulating embryonic development, differentiation, and pathways like TGF-β/smad, PI3K/Akt, and Wnt. Although aberration in HOXC6 promotes onset and progression of several cancers, our previous study indicated an oncogenic …

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Abstract 7340: Investigating the function and impact of UBASH3B in head and neck squamous cell carcinoma and its implications for racial health disparities

Madeleine Ndahayo, Vera Mukhina, Ishita Gupta, Daria A. Gaykalova

Abstract Head and Neck Squamous Cell Carcinoma (HNSCC) is one of the top cancers with significant cancer health disparities among racial and ethnic groups. African Americans (AAs) with HNSCC demonstrate worse overall survival compared to European Americans (EAs). While the reasons behind …

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