Walaa A Alshahrani

Effectiveness and safety of brentuximab vedotin-containing regimen versus standard chemotherapy in relapsed or refractory Hodgkin lymphoma: a multicenter cohort study

Abdullah M. Alrajhi, Bashayer Alshehri, Walaa A Alshahrani, Arwa Alhaj Issa et autres

Introduction: Hodgkin Lymphoma (HL) accounts for 3.4% of all cancers in Saudi Arabia and poses significant challenges with relapse rates reaching 40% in advanced stages. Brentuximab vedotin (BV), a novel agent targeting CD-30, has shown promise in improving outcomes. This study aims …

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Clinical Outcomes with the Use of Dipeptidyl Peptidase-4 (DPP-4) Inhibitor Among Patients with Diabetes Mellitus and COVID-19: A Systematic Review of Observational Studies

Shaden A. Alkhalifah, Walaa A Alshahrani, Abdulmajeed M. Alshehri, Majed S. Al Yami

Background: Diabetics with coronavirus disease 2019 (COVID-19) manifest more adverse clinical outcomes with elevated rates of death. It has been suggested that the SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) pathway of entrance into the host cell might be assisted by dipeptidyl …

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Reduced Versus Full-Dose Direct Oral Anticoagulants for Long-Term Management of Venous Thromboembolism: A Systematic Review

Manar Al Arifi, Walaa A Alshahrani, Abdulmajeed M. Alshehri, Majed S. Al Yami

Background: Venous thromboembolism (VTE) is still a serious clinical problem because many patients still have a significant chance of having it happen again after their first course of anticoagulation is over. In recent years, reduced-dose direct oral anticoagulants (DOACs) have been investigated …

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Anemia as a Potent and Underrecognized Driver of Venous Thromboembolism: A Systematic Review

Ghaith K. Mansour, Walaa A Alshahrani, Lama Alfehaid, Abdulmajeed M. Alshehri et autres

Background: Nutritional deficiency anemias—including iron, vitamin B12, and folate deficiencies—are common worldwide and are increasingly recognized as potential contributors to venous thromboembolism (VTE). Mechanistic and epidemiologic data suggest that anemia may promote thrombosis through hypoxia, endothelial activation, reactive thrombocytosis, and hyperhomocysteinemia. However, …

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Clinical Outcomes Associated with Statin Use in Pulmonary Embolism: A Systematic Review of Observational Studies

Walaa A Alshahrani, Abdulmajeed M. Alshehri, Majed S. Al Yami

Background: Pulmonary embolism (PE) represents one of the most serious complications of venous thromboembolism (VTE). Conflicting studies indicate that statins could play a role in preventing recurrent VTE or improving survival in patients with PE. This review aims to assess the impact …

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Evaluation of the Clinical Outcomes of Apixaban Use in Patients with Atrial Fibrillation and Uncontrolled Hypothyroidism: A Real-world Evidence

Khalid Al Sulaiman, Manal A Aljohani, Abdullah F. Alharthi, Hisham A. Badreldin et autres

IntroductionAtrial fibrillation (AF) poses a substantial worldwide health concern, significantly increasing the risk of stroke and morbidity. Direct oral anticoagulants (DOACs) such as apixaban are recommended over vitamin K antagonists for the management of AF. However, the impact of thyroid abnormalities on …

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Acceptance of Pulmonary Telerehabilitation Among Healthcare Practitioners

Gayathri Pandurangam, Swathi Gurajala, Laila Almarhoon, Talah Aljaloud et autres

INTRODUCTION: Pulmonary rehabilitation is a clinical approach designed to support individuals with chronic respiratory diseases through structured exercise and educational strategies. Pulmonary telerehabilitation (PTR) represents a remote adaptation of this approach, offering services through virtual platforms. This model may enhance patient engagement …

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Clinical features and outcomes of newly diagnosed classical Hodgkin lymphoma patients in Saudi Arabia: a multicenter cohort study

Mai Alalawi, Abdullah M. Alrajhi, Walaa A Alshahrani, Amal H. Alotaibi et autres

Classical Hodgkin Lymphoma (cHL) is a prominent B-cell neoplasm, that impacts global and Saudi populations. Given limited large-scale studies focusing on HL in Saudi Arabia, this retrospective multicenter cohort study reviewed the characteristics and clinical outcomes of patients with cHL in Saudi …

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Effectiveness and Safety of Nirmatrelvir-Ritonavir in Hospitalized Patients with COVID-19: A Two-center Cohort Study

Raghad Alhajaji, Manal Z. Alfahmi, Khalid Al Sulaiman, Aisha Alharbi et autres

Abstract Background: On May 25, 2023, the antiviral medication nirmatrelvir-ritonavir received complete FDA authorization, making it the first oral antiviral to treat mild-to-moderate COVID-19 in high-risk patients for progression to severe COVID-19. While the effect of nirmatrelvir-ritonavir is endorsed in non-hospitalized patients, …

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Real-World safety and effectiveness of evolocumab in primary hypercholesterolemia and mixed dyslipidemia in Saudi Arabia

Abdulaali R. Almutairi, Walaa A Alshahrani, Ghaida K Alhathlol, Fatimah Alsheikh et autres

Introduction: Evolocumab's short-term efficacy and safety were proven in phase-3 clinical trial, but its long-term safety and effectiveness in the Saudi population are yet to be studied. The aim of this study was to assess the long-term safety and effectiveness of evolocumab …

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Effectiveness and Safety of GLP-1 Receptor Agonists in Patients with Type 1 Diabetes

Sumaya N. Almohareb, Osamah M. Alfayez, Shoroq S. Aljuaid, Walaa A Alshahrani et autres

Background: GLP-1 receptor agonists (GLP-1RA) are used in the management of type II diabetes mellitus or obesity, although its role in patients with type I diabetes mellitus (T1DM) has been debated. This study aimed to investigate the efficacy and safety of GLP-1RA …

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Safety and Effectiveness of Direct Oral Anticoagulants Versus Warfarin in Patients with Venous Thromboembolism using Real-World Data: A Systematic Review and Meta-Analysis

Walaa A Alshahrani, Razan Alshahrani, Munirah A. Alkathiri, Saeed M. Alay et autres

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