Aleksandra Czernicka

Hair Manganese as a Marker of Cardiometabolic Status Rather than Coronary Artery Disease Severity—An Exploratory Pilot Study

Ewelina A. Dziedzic, Aleksandra Czernicka, Agnieszka Mazur-Jax, Andrzej Osiecki et autres

Background: Manganese (Mn) is an essential trace element with antioxidant properties; however, excessive exposure may contribute to inflammation and vascular dysfunction. Hair analysis provides an indicator of long-term Mn exposure. This study evaluated the relationship between hair Mn levels, acute coronary syndrome …

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Hair Calcium Levels in Relation to Coronary Artery Disease Severity and Systemic Inflammation Markers: A Pilot Study

Ewelina A. Dziedzic, Aleksandra Czernicka, Jakub S. Gąsior, Anna Szamreta-Siwicka et autres

Background: Coronary artery disease (CAD) is a leading global cause of mortality. The role of calcium (Ca), a key metabolic and structural element, in atherosclerosis and inflammation remains unclear. Ca influences immune cell function and is a component of atherosclerotic plaques. Hair …

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Targeting GABA signaling in type 1 diabetes and its complications- an update on the state of the art

Dariusz Łaszczych, Aleksandra Czernicka, Katarzyna Łaszczych

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Cancer stem cells and their role in metastasis

Michał Cezary Czarnogórski, Aleksandra Czernicka, Krzysztof Koper, Piotr Petrasz et autres

Introduction: Cancer, next to cardiovascular diseases, remains the primary concern of modern medicine in developed countries. Despite the unprecedented progress in targeted therapies and personalised medicine, including immunotherapy and gene therapy, we are still unable to efficiently treat many malignancies. One of …

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Urinary incontinence as the first clinical symptom of urinary bladder leiomyosarcoma

Łukasz Mazurczyk, Michał Cezary Czarnogórski, Aleksandra Czernicka, Paweł Lipowski et autres

Urinary bladder leiomyosarcoma is an extremely rare malignancy of the urogenital system. We present the case of a 59-year-old Caucasian male with a gigantic bladder leiomyosarcoma. The patient was subdued to the surgical excision of the urinary bladder - laparoscopic radical cystectomy …

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Ophthalmologic symptoms as the first manifestation of primary complete empty sella syndrome- case report

Dariusz Łaszczych, Aleksandra Czernicka, Bartłomiej Szymczak, Jędrzej Borowczak

Background: Empty sella syndrome (ESS) is a rare condition associated with loss of pituitary gland volume. ESS has a heterogeneous clinical manifestation including endocrine, neurological, and visual deficits. The most common symptoms include chronic headaches and hormonal disturbances associated with hypopituitarism.Aim of …

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Interaction between warfarin and selected superfoods: a comprehensive review of potential mechanisms and their clinical significance

Dariusz Łaszczych, Aleksandra Czernicka, Kornelia Kędziora–Kornatowska

Warfarin is one of the oldest and still widely used anticoagulant agents. Interactions between warfarin and herbs have been intensively studied in recent years. However, due to the growing worldwide interest and consumption of herbal products this area requires further investigations. Patients …

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The role of IL-17 in the pathogenesis and treatment of glioblastoma—an update on the state of the art and future perspectives

Dariusz Łaszczych, Aleksandra Czernicka, Karol Gostomczyk, Łukasz Szylberg et autres

Glioblastoma (GBM) is the most common malignant brain tumor, which, despite significant progress made in the last years in the field of neuro-oncology, remains an incurable disease. GBM has a poor prognosis with a median survival of 12-15 months, and its aggressive …

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Tyrosol and Hydroxytyrosol: Their Role in Cardioprotection

Cezary Guzowski, Joanna Murawska, Martyna Michalska, Karolina Winiarek et autres

Introduction: Recent research are focused on natural compounds for preventing cardiovascular diseases, with emphasis on tyrosol and hydroxytyrosol in olive oil. Cardiovascular diseases are linked to risk factors, and adopting a Mediterranean diet rich in these compounds is recognized for reducing risks. …

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Atypical granular cell tumour of urinary bladder – case report of an extremely rare neoplasm

Dominika Muniak, Dariusz Łaszczych, Aleksandra Czernicka, Tomasz Drewa et autres

We report a case of a 59-year-old woman presenting with haematuria and suprapubic pain. Cystoscopy revealed a spherical lesion within the urinary bladder, which was subsequently removed by transurethral resection. Histopathology confirmed the diagnosis of an atypical granular cell tumour (AGCT). So …

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