Yujia Yu

Research Progress of Diabetes-related Glaucoma: Mechanisms, Impacts and Management Strategies

Liping He, Jinshen Liu, Yujia Yu, Chen Hu et autres

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Advances in Traditional Chinese Medicine for Diabetic Glaucoma: A Systematic Review From Holistic Pathogenesis to Multi‐Target Interventions

Jinshen Liu, Yujia Yu, Chen Hu, Feng Cheng et autres

Diabetic glaucoma, a severe microvascular and neurodegenerative complication of diabetes, involves complex pathological mechanisms including chronic hyperglycemia‑induced oxidative stress, inflammatory responses, microcirculatory disturbances, and retinal ganglion cell (RGC) apoptosis. While conventional Western medicine has achieved significant success in intraocular pressure (IOP) control, …

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Research progress in animal models of dry eye disease: Types, mechanisms, and application prospects

Jinshen Liu, Jiaqi Chen, Zhonghui Li, Jiamin Zhou et autres

Dry eye disease (DED) is a prevalent and complex multifactorial ocular surface disorder, leading to significant visual discomfort and diminished quality of life. Animal models are indispensable tools for investigating DED pathology and evaluating therapeutic interventions. This review aims to systematically summarize …

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Research Advances in Glanimal Models of Glaucoma: Exploring Multidimensional Mechanisms and Novel Therapeutic Strategies

Jinshen Liu, Hui Zhang, Jiaqi Chen, Jiamin Zhou et autres

Objective: Glaucoma is a complex optic neuropathy characterized by the progressive loss of retinal ganglion cells (RGCs). Animal models are crucial tools for deciphering its multidimensional pathogenesis and evaluating novel therapeutic strategies. This review aims to systematically summarize the establishment methods, application …

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Effect of antioxidants on primary open-angle glaucoma: a systematic review and meta-analysis

Jie Bao, Yujia Yu, G Chen, Hu Chen et autres

Background/Objectives: Primary open-angle glaucoma is a major global cause of vision loss, severely impacting quality of life. Although the need for effective treatments is widely recognized, the efficacy and safety of antioxidants remain uncertain. In this systematic review and meta-analysis, we aimed …

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Potential application of traditional Chinese medicine in age-related macular degeneration—focusing on mitophagy

Yujia Yu, Gaofeng Wang, Yong Liu, Zhaoru Meng

Retinal pigment epithelial cell and neuroretinal damage in age-related macular degeneration (AMD) can lead to serious visual impairments and blindness. Studies have shown that mitophagy, a highly specialized cellular degradation system, is implicated in the pathogenesis of AMD. Mitophagy selectively eliminates impaired …

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Role of traditional Chinese medicine in age-related macular degeneration: exploring the gut microbiota’s influence

Yujia Yu, Yong Liu, Zhaoru Meng

The pathogenesis of age-related macular degeneration (AMD), a degenerative retinopathy, remains unclear. Administration of anti-vascular endothelial growth factor agents, antioxidants, fundus lasers, photodynamic therapy, and transpupillary warming has proven effective in alleviating symptoms; however, these interventions cannot prevent or reverse AMD. Increasing …

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