Philipp Hoegen-Saßmannshausen

Multicenter analysis of MRI-guided, stereotactic body radiotherapy as ablative treatment for lymph nodal metastases of the abdomen and pelvis

Jens von der Grün, Sebastian Regnery, Juliane Hörner‐Rieber, Philipp Hoegen-Saßmannshausen et autres

BACKGROUND: Purpose of this study was to assess safety and efficacy of magnetic resonance-imaging (MRI)-guided, stereotactic body radiotherapy (SBRT) for lymph nodal metastases (LNM) of the abdomen and pelvis. METHODS: This multi-center retrospective study was conducted at four institutions practicing online-adaptive, MRI-guided …

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Postoperative radiotherapy in subtotally resected recurrent WHO grade 1 meningiomas with intermediate-/high-risk molecular profiles

Maximilian Deng, Sybren L. N. Maas, Günes Anil, Philipp Sievers et autres

BACKGROUND: Meningiomas represent the most common primary intracranial tumors in adults, with World Health Organization (WHO) grade 1 typically associated with favorable outcomes following gross total resection (GTR). METHODS: This retrospective study included patients with CNS WHO grade 1 meningioma and available …

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Partial Breast Reirradiation for Breast Cancer Recurrences After Repeat Breast-Conserving Surgery with Proton Beam Therapy: The Prospective BREAST Trial (NCT06954623)

Eva Meixner, Semi Harrabi, Katharina Seidensaal, Beata Koczur et autres

(1) Background: The management of ipsilateral breast cancer recurrence depends on the extent of the tumor, and staging results, and mastectomy is currently the standard of care for previously irradiated patients. Studies are increasingly investigating suitable candidates for the repeated use of …

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566 Multicenter Analysis of MRI-guided, Stereotactic Body Radiotherapy as Ablative Treatment for Lymph Nodal Metastases of the Abdomen and Pelvis

Jens von der Grün, Sebastian Regnery, Juliane Hörner‐Rieber, Inga Jessen et autres

4168 Prospective clinical evaluation of fully automated contouring and treatment planning for prostate radiotherapy

David Neugebauer, Jan-Hendrik Bolten, Stephan Mende, Tilmann Rackwitz et autres

2522 SHARP - Stereotactic heart ablative radiotherapy: First data of the prospective multicenter SHARP-study (DRKS00027108)

Aurélie Gaasch, Sebastian Marschner, Philipp Hoegen-Saßmannshausen, Elisabetta Sandrini et autres

Intrafractional Motion in Online-Adaptive Magnetic Resonance-Guided Radiotherapy of Adrenal Metastases Leads to Reduced Target Volume Coverage and Elevated Organ-at-Risk Doses

Philipp Hoegen-Saßmannshausen, Tobias P. Hartschuh, C. Katharina Renkamp, Carolin Buchele et autres

BACKGROUND/OBJECTIVES: Stereotactic body radiotherapy is frequently used in patients with adrenal metastases. Motion of adherent radiosensitive organs at risk (OARs) and tumors influence OAR toxicity and tumor control. Online-adaptive Magnetic Resonance-guided radiotherapy (MRgRT) can address and mitigate interfractional changes. However, the impact …

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Prospective planning comparison of magnetic resonance-guided vs. internal target volume-based stereotactic body radiotherapy of hepatic metastases – Which patients do really benefit from an MR-linac?

Philipp Hoegen-Saßmannshausen, C. Katharina Renkamp, David Neugebauer, Nina I. Niebuhr et autres

Purpose/objective: To compare online MR-guided SBRT (MRgRT) of liver metastases with state-of-the-art ITV-based SBRT (ITV-SBRT) and assess which patients benefit most from MRgRT. Materials and methods: ) of 100 Gy was feasible with ITV-SBRT. Otherwise, patients were treated with MRgRT. In this …

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Stereotactic body radiotherapy with carbon ions as local ablative treatment in patients with primary liver cancer

Paula Hoffmeister‐Wittmann, Philipp Hoegen-Saßmannshausen, Livia Wicklein, Fabian Weykamp et autres

BACKGROUND AND AIMS: Liver cancer is the third leading cause of cancer related death due to treatment resistance and late onset of symptoms (Rumgay in J Hepatol 77: 1598-1606, 2022). The role of external beam radiotherapy (EBRT) in treatment of unresectable liver …

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Accuracy of an articulated head-and-neck motion model using deep learning-based instance segmentation of skeletal bones in CT scans for image registration in radiotherapy

Alexandra Walter, Cornelius J. Bauer, Ama Katseena Yawson, Philipp Hoegen-Saßmannshausen et autres

Knowing about anatomical deformations in patient images is crucial for adaptive image-guided radiation therapy. Biomechanical models ensure biofidelity in deformable image registration, but manual contouring limits their clinical use. We investigate the application of automatically generated contours for a biomechanical registration model …

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How to protect the proximal bronchial tree during stereotactic radiotherapy of ultracentral lung tumors: Lessons from MR-guided treatment

Sebastian Regnery, Efthimios Katsigiannopulos, Hin Lau, Philipp Hoegen-Saßmannshausen et autres

Purpose: To use imaging data from stereotactic MR-guided online adaptive radiotherapy (SMART) of ultracentral lung tumors (ULT) for development of a safe non-adaptive approach towards stereotactic body radiotherapy (SBRT) of ULT. Patients and Methods: Analysis is based on 19 patients with ULT …

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Hematologic Toxicity Profiles and the Impact of Hemoglobin Nadir and Transfusion on Oncologic Outcome in Definitive Radiochemotherapy for Cervical Cancer

Eva Meixner, Laura Wermes, Line Hoeltgen, Lisa Antonia von Diest et autres

Background/Objectives: Definitive radiochemotherapy with concomitant cisplatin 40 mg/m2 weekly represents the standard of care for locally advanced cervical cancer. Current studies (KEYNOTE-A18 and INTERLACE) are intensifying this regimen at the cost of increased hematologic toxicity. We aimed to evaluate influencing factors on …

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