A. A. Melnitskaia

Aging and human longevity. Volume 1. Edited by O. N. Tkacheva

Anastasiia V. Badaeva, Arina E. Veriaskina, A. V. Vitebskaya, N. M. Vorobyeva et autres

The book Aging and Human Longevity edited by O.N. Tkacheva was authored by leading Russian gerontologists and geriatricians. It synthesizes both global and Russian advancements in the study of aging. The monograph is composed of two volumes, which systematically investigate the phenomenon …

RUSS-AGE study: Markers of carbohydrate metabolism and their time course in different age groups of a healthy population of the Russian Federation

Anna K. Ilyushchenko, Arina E. Veriaskina, Lubov V. Matchekhina, A. A. Melnitskaia et autres

Background. One of the important tasks of modern science is to search for key biomarkers of aging of various body systems. Parameters of carbohydrate metabolism play an essential role in maintaining vital activity. The prevalence of carbohydrate metabolism disorders increases with age, …

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Associations of IGF-1 and IGFBP-3 with aging and the development of age-associated diseases

Anna K. Ilyushchenko, Lubov V. Matchekhina, A. A. Melnitskaia, Irina Dmitrievna Strazhesko

Aging is a complex biological process impacting various systems of the body, with changes occurring at molecular, cellular, and physiological levels. This review focuses on the role of insulin-like growth factors (IGFs) and insulinlike growth factor-binding proteins (IGFBPs) in aging process. IGF-1 …

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The gut microbiome as a central player in aging: mechanisms and health outcomes

A. A. Melnitskaia, Lubov V. Matchekhina, Anna K. Ilyushchenko, Irina Dmitrievna Strazhesko

The article explores the mechanisms by which the gut microbiome influences human aging and associated diseases. The authors examine age-related changes in the composition of the microbiota and their effects on inflammation, immune response, and intestinal barrier permeability. Special attention is given …

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On the Gut Microbiome as a Central Player in Aging: Mechanisms and Health Outcomes

A. A. Melnitskaia, Lubov V. Matchekhina, Anna K. Ilyushchenko, Irina Dmitrievna Strazhesko

Abstract The work explores the mechanisms by which the gut microbiome influences human aging and associated diseases. We examine age-related changes in the composition of the microbiota and their effects on inflammation, immune response, and intestinal-barrier permeability. Special attention is given to …

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Associations of IGF-1 and IGFBP-3 with Aging and the Development of Age-Associated Diseases

Anna K. Ilyushchenko, Lubov V. Matchekhina, A. A. Melnitskaia, Irina Dmitrievna Strazhesko

Abstract Aging is a complex biological process that impacts various systems of the body with changes occurring at molecular, cellular, and physiological levels. One of the key elements in the study of aging is determination of the role of insulin-like growth factors …

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Cost-effectiveness of the biological age calculator

Mikhail S. Arbatskiy, Dmitriy E. Balandin, A. A. Melnitskaia

Relevance. The analysis of numerous data from clinical studies over the last decades has revealed regularities between certain clinical parameters and patient age. The correspondence between certain indicators characteristic of different age groups has made it possible to differentiate between biological age …

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RUSS-AGE: developed research protocol for the creation of Russian biological age calculators

A. A. Melnitskaia, Lubov V. Matchekhina, О. Н. Ткачева, Anna K. Ilyushchenko et autres

Background. Life expectancy is increasing around the globe. However, chronological age is not the best indicator of health. For a more accurate assessment of body condition throughout life, in general, and aging, in particular, and identify potential points of geroprotective intervention, a …

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Senolytic drugs: implications for clinical practice

Anna K. Ilyushchenko, Lubov V. Matchekhina, О. Н. Ткачева, A. V. Balashova et autres

The aging mechanisms study is one of the most important aims in the field of geroscience and clinical medicine. There has been a wide range of fundamental research data accumulated on this matter. The processes associated with regeneration capability decrease, age-related decline …

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Senolytic Drugs: Implications for Clinical Practice

Anna K. Ilyushchenko, Lubov V. Matchekhina, A. V. Balashova, A. A. Melnitskaia et autres

Abstract Studying the mechanisms of aging is one of the most important goals of modern science. A significant amount of data on the processes associated with a decrease in the functional ability to regenerate, cell proliferation and resistance to adverse factors with …

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Исследование RUSS-AGE: маркеры углеводного обмена и их динамика в разных возрастных группах здоровой популяции РФ

Ильющенко Анна Константиновна, Arina E. Veriaskina, Мачехина Любовь Викторовна, A. A. Melnitskaia et autres