Accès ouvert
2026
preprint
OpenAlex
Shilpi Singh, Akhilesh Kumar Maurya, Iteeshree Mohapatra, Stefan Kim et autres
ABSTRACT Repair of ionizing-radiation (IR)-induced membrane damage is essential for cell survival, and Annexin A2 (ANXA2) mediates this repair by promoting shedding of microvesicles containing both damaged lipid and ANXA2. Here, we show that coupling this process to microRNA export contributes to …
us, in
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Gatikrushna Singh, Shilpi Singh, Iteeshree Mohapatra, Jay Hou et autres
. Temozolomide (TMZ) treatment induced cross-resistance to radiation and acquired resistance to TMZ; both forms of resistance were eliminated by RAD51 silencing or miR-181d transfection. Finally, the exogenous introduction of miR-181d in an immunocompetent murine glioblastoma model before radiation treatment induced anti-glioblastoma …
us, in
(code pays fourni par la source)
Accès ouvert
2025
conference-abstract
OpenAlex
Gatikrushna Singh, Shilpi Singh, Iteeshree Mohapatra, Haoyi Zheng et autres
Abstract BACKGROUND Glioblastoma trials targeting base excision repair (BER) by inhibiting methyl-guanine methyl transferase (MGMT), the key mechanism for repairing temozolomide-induced DNA damage, have yielded disappointing results. One explanation for the disappointing results of these clinical trials of BER inhibitors involves the …
us
(code pays fourni par la source)
Accès ouvert
2025
conference-abstract
OpenAlex
Gatikrushna Singh, Shilpi Singh, Iteeshree Mohapatra, Stefan Kim et autres
Abstract BACKGROUND The concepts of mean and variance serve complementary roles in biological research. While the former captures the central tendencies of a trait in populations, the latter defines the degree of spread or dispersion of the data points relative to that …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Gatikrushna Singh, Shilpi Singh, Iteeshree Mohapatra, Stefan Kim et autres
Intratumoral heterogeneity plays a pivotal role in cancer evolution, providing the substrate for adaptation to selective pressures, including chemotherapy treatment. Here, we demonstrate that miR-181d modulates variability in methyl-guanine methyl transferase (MGMT) expression, contributing to this heterogeneity in glioblastoma, the most common …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Shilpi Singh, Iteeshree Mohapatra, Debashis Barik, Haoyi Zheng et autres
Abstract Glioblastoma remains the most aggressive and treatment-resistant brain malignancy, driven by genetic heterogeneity, metabolic plasticity, and an immunosuppressive tumor microenvironment (TME). Current therapies rely on inducing tumor cell death through DNA damage; however, glioma stem cells (GSCs) upregulate compensatory DNA repair …
us, in
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Shilpi Singh, Devanjan Dey, Debashis Barik, Iteeshree Mohapatra et autres
Glioblastoma (GBM) remains the most aggressive and lethal brain tumor in adults and poses significant challenges to patient survival. This review provides a comprehensive exploration of the molecular and genetic landscape of GBM, focusing on key oncogenic drivers, such as epidermal growth …
us, in
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Gatikrushna Singh, Shilpi Singh, Iteeshree Mohapatra, Stefan Kim et autres
Abstract Intratumoral heterogeneity plays a pivotal role in cancer evolution, providing the substrate for adaptation to selective pressures, including treatment with chemotherapy. Here, we show that micro-RNA regulation of variance in the expression of the DNA repair protein methyl-guanine methyl transferase (MGMT) …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Sujata Prasad, Shilpi Singh, Samuel Menge, Iteeshree Mohapatra et autres
The gastrointestinal (GI) tract redox environment, influenced by commensal microbiota and bacterial-derived metabolites, is crucial in shaping T-cell responses. Specifically, metabolites from gut microbiota (GM) exhibit robust anti-inflammatory effects, fostering the differentiation and regulation of CD8+ tissue-resident memory (TRM) cells, mucosal-associated invariant …
us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Shilpi Singh, Debashis Barik, Karl Lawrie, Iteeshree Mohapatra et autres
The mTOR signaling pathway plays a pivotal and intricate role in the pathogenesis of glioblastoma, driving tumorigenesis and proliferation. Mutations or deletions in the PTEN gene constitutively activate the mTOR pathway by expressing growth factors EGF and PDGF, which activate their respective …
us, in
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Shilpi Singh, Debashis Barik, Ananta Prasad Arukha, Sujata Prasad et autres
Conventional and cancer immunotherapies encompass diverse strategies to address various cancer types and stages. However, combining these approaches often encounters limitations such as non-specific targeting, resistance development, and high toxicity, leading to suboptimal outcomes in many cancers. The tumor microenvironment (TME) is …
us, in
(code pays fourni par la source)