Burhan Yokus

PCSK9 inhibition attenuates alcohol-induced cardiovascular dysfunction and links hepatic lipid accumulation to impaired myocardial contractile reserve

Csaba Mátyás, Eszter Trojnár, Partha Mukhopadhyay, Suxian Zhao et autres

Excessive alcohol consumption accelerates cardiovascular aging by promoting oxidative stress, inflammation, lipid dysregulation, fibrotic remodeling, and loss of ventricular-vascular reserve. PCSK9, a key regulator of cholesterol metabolism, has emerged as a mediator of age-related cardiovascular dysfunction and alcohol-associated liver and neurovascular injury. …

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Chronic Liver Disease-Related Osteoporosis: From Mechanisms to Precision Intervention

Wenjing Wang, Guangyu Liu, Burhan Yokus, Taiqiang Yan et autres

BACKGROUND & AIMS: Patients with chronic liver disease (CLD) frequently develop reduced bone mass and an increased risk of fragility fractures, making osteoporosis a major extrahepatic complication that affects long-term prognosis and quality of life. Although the association between CLD and osteoporosis …

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The Link between Alcohol Consumption and Kidney Injury

Burhan Yokus, Luca Maccioni, Lihong Fu, György Haskó et autres

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Exacerbated cardiac dysfunction from combined alcohol binge and synthetic cannabinoid use

János Pálóczi, Ozge Gunduz‐Cinar, Burhan Yokus, Bruno Paes‐Leme et autres

Alcohol remains the most frequently used intoxicant, posing a significant global health concern. Binge drinking has been linked to acute cardiovascular complications, including reduced cardiac performance, arrhythmias, and blood pressure instability. Additionally, there is a growing number of clinical reports describing severe …

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An Update on IL-22 Therapies in Alcohol-Associated Liver Disease and Beyond

Lihong Fu, Burhan Yokus, Bin Gao, Pál Pacher

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Chronic alcohol consumption accelerates cardiovascular aging and decreases cardiovascular reserve capacity

Partha Mukhopadhyay, Burhan Yokus, Bruno Paes‐Leme, Sándor Bátkai et autres

The pathology of cardiovascular aging is complex, involving mitochondrial dysfunction, oxidative and nitrative stress, oxidative DNA injury, impaired lipid metabolism, cell death, senescence, and chronic inflammation. These processes lead to remodeling and structural changes in the cardiovascular system, resulting in a progressive …

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Data-driven transcriptomics analysis identifies PCSK9 as a novel key regulator in liver aging

Muhammad Arif, Csaba Mátyás, Partha Mukhopadhyay, Burhan Yokus et autres

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