B. Ndao

Multidimensional immune profiling uncovers biphasic peripheral T-cell dynamics after chemoradiation in patients with locally advanced head and neck cancer

Benoît Lecoester, Yaoyao Xie, X. Sun, A. Renaudin et autres

Cisplatin-based concurrent chemoradiation (CRT) remains the standard treatment for locally advanced head and neck squamous cell carcinoma (LA-HNSCC), yet recurrence rates remain high. Attempts to combine immune checkpoint inhibitors with CRT have not improved outcomes, underscoring the need to better understand CRT-driven …

fr, cn (code pays fourni par la source)

Pivekimab sunirine in blastic plasmacytoid dendritic cell neoplasm: assessing spatial response and unraveling resistance mechanisms

Margaux Poussard, Morgane Boichut, Imane Belakri, Sabeha Biichlé et autres

Not available.

fr, lu, us (code pays fourni par la source)

UCPVax, a CD4 helper peptide vaccine, induces polyfunctional Th1 cells, antibody response, and epitope spreading to improve antitumor immunity

Caroline Laheurte, Laura Boullerot, B. Ndao, Marine Malfroy et autres

The induction of an antitumor CD4 + T helper response is essential for the efficacy of therapeutic cancer vaccines. However, few vaccines are specifically designed to target CD4 + T cells in human cancers. Here, we characterize the immune mechanisms of UCPVax, …

fr, ch, us (code pays fourni par la source)

Characterization of the aryl hydrocarbon receptor as a potential candidate to improve cancer T cell therapies

Valentine De Castro, Oumaïma Abdellaoui, Barbara Dehecq, B. Ndao et autres

The efficacy of T-cell-based cancer therapies can be limited by the tumor microenvironment which can lead to T cell dysfunction. Multiple studies, particularly in murine models, have demonstrated the capacity of the aryl hydrocarbon receptor (AHR) to negatively regulate antitumor T cell …

fr (code pays fourni par la source)

TIE-2–Expressing Monocytic Myeloid-Derived Suppressor Cells Are Involved in Resistance to Anti–PD-1 Therapy Mediated by Angiopoietin 2 in Patients with Melanoma

Amélie Marguier, B. Ndao, Mylène Wespiser, Victor Pereira et autres

fr (code pays fourni par la source)

221P Chemoradiotherapy induced adaptive anti-tumor T cell immunity in patients with non-small cell lung cancer

Ying Xie, B. Ndao, Benoît Lecoester, M. Malfroy et autres

fr, cn (code pays fourni par la source)

33P Tumor-specific CD4 Th1 responses in long-term responder melanoma patients treated with immune checkpoint inhibitors

J.-F. Mathiot, B. Ndao, L. Boullerot, A. Marguier et autres

Background: Pathological complete response (pCR) is the strongest patient-level prognostic factor in patients with early triple-negative breast cancer (TNBC) undergoing neoadjuvant chemo-immunotherapy (NAT).Blood-based biomarkers have been proposed to recapitulate the immune-milieu and to anticipate benefit from NAT.We explored correlations between pCR and …

fr (code pays fourni par la source)

LB1657 Tie-2 expressing monocytic myeloid-derived suppressor cells represent a resistance mechanism to anti-PD-1 therapy in melanoma

Agathe Marguier, Charlée Nardin, B. Ndao, M. Wespiser et autres

fr (code pays fourni par la source)