Accès ouvert
2026
article
OpenAlex
Ernesto Relova-Hernández, Ana Beatriz Díaz-Bravo, Arleen Cantero-Rodríguez, Rydell Álvarez-Arzola et autres
Interleukin-2 (IL-2) has pleiotropic roles within the immune system. Its functional versatility depends upon the interactions with diverse arrays of receptor subunits differentially expressed on immune cell subsets. The balance between stimulation of regulatory T cells (Tregs) and effector lymphocytes determines the …
cu
(code pays fourni par la source)
2025
article
OpenAlex
Ernesto Relova-Hernández, Ana Beatriz Díaz-Bravo, Rodrigo Pedroso, Miguel Ángel Gonzalez-Cruz et autres
The main limitations of cancer treatment with high doses of recombinant interleukin 2 (IL-2) are high toxicity and the undesired expansion of regulatory T cells. The generation of IL-2 mutated variants (muteins) with changes in the affinity for different chains of the …
cu, pt
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Gertrudis Rojas, Ernesto Relova-Hernández, Annia Pérez‐Riverón, Camila Castro-Martínez et autres
Interleukin-2 (IL-2) engineered versions, with biased immunological functions, have emerged from yeast display and rational design. Here we reshaped the human IL-2 interface with the IL-2 receptor beta chain through the screening of phage-displayed libraries. Multiple beta super-binders were obtained, having increased …
cu, de, pt
(code pays fourni par la source)