Helge Schöppe

Bioluminate and Osprey data - Highly specific SARS-CoV-2 main protease (Mpro) mutations against the clinical antiviral ensitrelvir selected in a safe, VSV-based system

Teresa Kaserer, Helge Schöppe

Osprey and Bioluminate Raw Data

Bioluminate, Osprey and Covalent Docking data - Study of key residues in MERS-CoV and SARS-CoV-2 main proteases for resistance against clinically applied inhibitors nirmatrelvir and ensitrelvir

Teresa Kaserer, Helge Schöppe

Bioluminate, Osprey, and Covalent docking Raw data

Bioluminate and Osprey data - A comprehensive study of SARS-CoV-2 main protease (Mpro) inhibitor-resistant mutants selected in a VSV-based system

Teresa Kaserer, Helge Schöppe

Bioluminate, Osprey and Covalent Docking data - Study of key residues in MERS-CoV and SARS-CoV-2 main proteases for resistance against clinically applied inhibitors nirmatrelvir and ensitrelvir

Teresa Kaserer, Helge Schöppe

Bioluminate, Osprey, and Covalent docking Raw data

Bioluminate and Osprey data - A comprehensive study of SARS-CoV-2 main protease (Mpro) inhibitor-resistant mutants selected in a VSV-based system

Teresa Kaserer, Helge Schöppe

Bioluminate and Osprey data - Highly specific SARS-CoV-2 main protease (Mpro) mutations against the clinical antiviral ensitrelvir selected in a safe, VSV-based system

Teresa Kaserer, Helge Schöppe

Osprey and Bioluminate Raw Data

Cdk6’s functions are critically regulated by its unique C-terminus

Alessia Schirripa, Helge Schöppe, Sofie Nebenfuehr, Markus Zojer et autres

The vital cell cycle machinery is tightly regulated and alterations of its central signaling hubs are a hallmark of cancer. The activity of CDK6 is controlled by interaction with several partners including cyclins and INK4 proteins, which have been shown to mainly …

at (code pays fourni par la source)

A comprehensive study of SARS-CoV-2 main protease (Mpro) inhibitor-resistant mutants selected in a VSV-based system

Francesco Costacurta, Andrea Dodaro, David Bante, Helge Schöppe et autres

Nirmatrelvir was the first protease inhibitor specifically developed against the SARS-CoV-2 main protease (3CLpro/Mpro) and licensed for clinical use. As SARS-CoV-2 continues to spread, variants resistant to nirmatrelvir and other currently available treatments are likely to arise. This study aimed to identify …

at, it, us, sg, sa (code pays fourni par la source)

Highly specific SARS-CoV-2 main protease (Mpro) mutations against the clinical antiviral ensitrelvir selected in a safe, VSV-based system

Stefanie Rauch, Francesco Costacurta, Helge Schöppe, Ju-Yi Peng et autres

In the SARS-CoV-2 pandemic, the so far two most effective approved antivirals are the protease inhibitors nirmatrelvir, in combination with ritonavir (Paxlovid) and ensitrelvir (Xocova). However, antivirals and indeed all antimicrobial drugs are sooner or later challenged by resistance mutations. Studying such …

at, us, sa (code pays fourni par la source)

Study of key residues in MERS-CoV and SARS-CoV-2 main proteases for resistance against clinically applied inhibitors nirmatrelvir and ensitrelvir

Laura Krismer, Helge Schöppe, Stefanie Rauch, David Bante et autres

Abstract The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an epidemic, zoonotically emerging pathogen initially reported in Saudi Arabia in 2012. MERS-CoV has the potential to mutate or recombine with other coronaviruses, thus acquiring the ability to efficiently spread among humans and …

at, sa, de (code pays fourni par la source)

Cdk6’s functions are critically regulated by its unique C-terminus

Alessia Schirripa, Sofie Nebenfuehr, Helge Schöppe, Markus Zojer et autres

The family of cyclin-dependent kinases (CDKs) comprises more than 20 serine/threonine kinases functioning in diverse cellular processes including cell-cycle progression and transcriptional regulation. Dysregulation of CDKs is directly linked to tumorigenesis, e.g. leukemic cells highly depend on CDK6, a pivotal component in …

at (code pays fourni par la source)

Highly Specific Sars-Cov-2 Main Protease (Mpro) Mutations Against the Clinical Antiviral Ensitrelvir Selected in a Safe, Vsv-Based System

Stefanie Rauch, Helge Schöppe, David Bante, Francesco Costacurta et autres

at, us (code pays fourni par la source)