Accès ouvert
2025
article
OpenAlex
Jakob Grove, Yuanjun Gu, Cornelia K. Buus, Lea K. Nielsen et autres
Abstract Although autism has historically been conceptualized as a condition that emerges in early childhood 1,2 , many autistic people are diagnosed later in life 3–5 . It is unknown whether earlier- and later-diagnosed autism have different developmental trajectories and genetic profiles. …
gb, dk, nl, it, no, us, il, ch, ca, tw, cl, ba, br, mx, au
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Accès ouvert
2025
article
OpenAlex
Christopher P. DiPietro, Shun Nakajima, Yuki Oe, Masaya Ito et autres
Abstract Anxiety sensitivity (AS) and distress tolerance (DT) are psychological constructs that measure one’s ability to accept difficult emotions and sensations. The Anxiety Sensitivity Index-3 (ASI-3) and Distress Tolerance Scale (DTS) are the pre-eminent instruments for measuring these constructs. This study examines …
us, jp
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Accès ouvert
2025
review
OpenAlex
Joshua Curtiss, Christopher P. DiPietro
BACKGROUND: Emotional disorders such as depression and anxiety affect millions globally and pose a significant burden on public health. Personalized treatment approaches using machine learning (ML) to predict treatment response could revolutionize treatment strategies. However, there is limited evidence as to whether …
us
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Accès ouvert
2024
article
OpenAlex
Chengyu Deng, Ryan Ziffra, Daniela A. Pereira, Schahram Akbarian et autres
Nucleotide changes in gene regulatory elements are important determinants of neuronal development and diseases. Using massively parallel reporter assays in primary human cells from mid-gestation cortex and cerebral organoids, we interrogated the cis-regulatory activity of 102,767 open chromatin regions, including thousands of …
us, jp, br
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Accès ouvert
2024
article
OpenAlex
W. Brad Ruzicka, Shahin Mohammadi, Sivan Subburaju, Daniel Reed Tso et autres
The complexity and heterogeneity of schizophrenia have hindered mechanistic elucidation and the development of more effective therapies. Here, we performed single-cell dissection of schizophrenia-associated transcriptomic changes in the human prefrontal cortex across 140 individuals in two independent cohorts. Excitatory neurons were the …
us, it
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Accès ouvert
2024
article
OpenAlex
Cindy Wen, Michael Margolis, Rujia Dai, Pan Zhang et autres
Neuropsychiatric genome-wide association studies (GWASs), including those for autism spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the developing brain. However, prioritizing risk genes and mechanisms is challenging without a unified regulatory atlas. Across 672 diverse developing human brains, …
us, fr, gb, cn
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Accès ouvert
2024
article
OpenAlex
Louise A. Huuki-Myers, Abby Spangler, Nicholas J. Eagles, Kelsey D. Montgomery et autres
The molecular organization of the human neocortex historically has been studied in the context of its histological layers. However, emerging spatial transcriptomic technologies have enabled unbiased identification of transcriptionally defined spatial domains that move beyond classic cytoarchitecture. We used the Visium spatial …
us, gb
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Accès ouvert
2024
article
OpenAlex
Prashant S. Emani, Jason Liu, Declan Clarke, Matthew Jensen et autres
Single-cell genomics is a powerful tool for studying heterogeneous tissues such as the brain. Yet little is understood about how genetic variants influence cell-level gene expression. Addressing this, we uniformly processed single-nuclei, multiomics datasets into a resource comprising >2.8 million nuclei from …
us, es, cn, sg
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Accès ouvert
2024
article
OpenAlex
Yan Xia, Cuihua Xia, Yi Jiang, Yu Chen et autres
Many psychiatric disorders exhibit sex differences, but the underlying mechanisms remain poorly understood. We analyzed transcriptomics data from 2160 postmortem adult prefrontal cortex brain samples from the PsychENCODE consortium in a sex-stratified study design. We compared transcriptomics data of postmortem brain samples …
us, cn
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Accès ouvert
2024
article
OpenAlex
Caroline M. Nievergelt, Adam X. Maihofer, Elizabeth G. Atkinson, Chia‐Yen Chen et autres
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European …
us, gb, dk, no, ba, br, mx, nl, au, ca, Afrique du Sud, it, xk, hr
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Caroline M. Nievergelt, Adam X. Maihofer, Elizabeth G. Atkinson, Chia‐Yen Chen et autres
Abstract Posttraumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of …
us, gb, no, ba, br, mx, au, dk, ca, Afrique du Sud, de, it, nl, xk, hr
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Chris Chatzinakos, Cameron D. Pernia, Filomene G. Morrison, Artemis Iatrou et autres
Objective: Multidisciplinary studies of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) implicate the dorsolateral prefrontal cortex (DLPFC) in disease risk and pathophysiology. Postmortem brain studies have relied on bulk-tissue RNA sequencing (RNA-seq), but single-cell RNA-seq is needed to dissect cell-type-specific …
us
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